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Research ArticleBRAIN

Fast Detection of Diffuse Axonal Damage in Severe Traumatic Brain Injury: Comparison of Gradient-Recalled Echo and Turbo Proton Echo-Planar Spectroscopic Imaging MRI Sequences

Elisabetta Giugni, Umberto Sabatini, Gisela E. Hagberg, Rita Formisano and Alessandro Castriota-Scanderbeg
American Journal of Neuroradiology May 2005, 26 (5) 1140-1148;
Elisabetta Giugni
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Umberto Sabatini
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Gisela E. Hagberg
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Rita Formisano
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Alessandro Castriota-Scanderbeg
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    Fig 1.

    Dual-echo high resolution t-PEPSI sequence (TR/TE1/TE2/NEX = 5000/50/145/1, flip angle = 90°).

    A, First-echo image obtained shows good lesion-to-tissue contrast.

    B, Second image in the same shot is not of satisfactory quality for lesion detection.

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    Fig 2.

    Four-echo t-PEPSI images (TR/TE1/TE2/TE3/TE4/NEX = 5000/23/64/105/145/1, flip angle = 90°).

    A, On the first-echo image, susceptibility effects of the lesion have not affected the image contrast to a great extent.

    B, Best lesion-to-tissue contrast is obtained around 50 msec.

    C and D, At longer TEs, contrast is lost.

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    Fig 3.

    Location of DAI lesions in deep intra-axial structures.

    A and B, GRE (A) and t-PEPSI (B) images show lesions in the corpus callosum, posterior left internal capsule, and right thalamus.

    C and D, GRE (C) and t-PEPSI (B) images show a right thalamic lesion.

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    Fig 4.

    Location of DAI lesions in the deep intra-axial structures.

    A and B, Lesions in the periventricular white matter and corpus callosum on GRE (A) and t-PEPSI (B) images.

    C and D, GRE image (C) shows slightly abnormal decrease in SI in the left mesial temporal region and in the left posterior lateral of the midbrain. Both lesions are more easily identified on the t-PEPSI image (D).

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    TABLE 1:

    Demographic and clinical data of 21 patients with severe TBI

    Patient/Sex/Age (y)Coma Duration (d)Interval, TBI to MR Imaging (mo)Glasgow Outcome Scale Score
    1/M/233035
    2/M/201884
    3/M/182564
    4/F/21735
    5/F/3718265
    6/M/253045
    7/M/2621304
    8/M/3010735
    9/M/2026133
    10/M/3130184
    11/M/262744
    12/M/205294
    13/M/281594
    14/M/221535
    15/M/381534
    16/M/31301124
    17/M/1821253
    18/M/3540163
    19/M/301564
    20/M/40801544
    21/M/2420173
    • View popup
    TABLE 2:

    DAI lesions detected with the two sequences in 21 patients with severe TBI

    Location of LesionLesions Detected
    GRE Imagingt-PEPSIOnly on GRE ImagingOnly on t-PEPSI
    Whole brain (n = 371)29123014180
    Frontal lobe (n = 158)126986032
    Temporal lobe (n = 88)74*37*5114
    Parietal lobe (n = 30)2220108
    Occipital lobe (n = 9)7812
    Basal ganglia (n = 28)232085
    Corpus callosum (n = 22)1218410
    Periventricular (n = 13)101213
    Infratentorial (n = 23)171766
    • * P <.004, Wilcoxon test.

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    TABLE 3:

    Characteristics of 150 small DAI lesions detected on GRE and t-PEPSI images

    Small Lesions*GRE Sequencet-PEPSI Sequence
    No.130 (86.7)87 (58.0)
    Mean diameter (mm)3.46 ± 2.074.92 ± 3.12
    Mean area (mm2)12.74 ± 21.7326.56 ± 39.18
    • Note.—Data are the number or the mean ± standard deviation. Data in parentheses are percentages.

    • * Diameter ≤5 mm.

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American Journal of Neuroradiology: 26 (5)
American Journal of Neuroradiology
Vol. 26, Issue 5
1 May 2005
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Cite this article
Elisabetta Giugni, Umberto Sabatini, Gisela E. Hagberg, Rita Formisano, Alessandro Castriota-Scanderbeg
Fast Detection of Diffuse Axonal Damage in Severe Traumatic Brain Injury: Comparison of Gradient-Recalled Echo and Turbo Proton Echo-Planar Spectroscopic Imaging MRI Sequences
American Journal of Neuroradiology May 2005, 26 (5) 1140-1148;

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Fast Detection of Diffuse Axonal Damage in Severe Traumatic Brain Injury: Comparison of Gradient-Recalled Echo and Turbo Proton Echo-Planar Spectroscopic Imaging MRI Sequences
Elisabetta Giugni, Umberto Sabatini, Gisela E. Hagberg, Rita Formisano, Alessandro Castriota-Scanderbeg
American Journal of Neuroradiology May 2005, 26 (5) 1140-1148;
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