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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePediatric Neuroimaging

Nasopharyngeal Carcinoma: Recognizing the Radiographic Features in Children

Hilda E. Stambuk, Snehal G. Patel, Kristine M. Mosier, Suzanne L. Wolden and Andrei I. Holodny
American Journal of Neuroradiology June 2005, 26 (6) 1575-1579;
Hilda E. Stambuk
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Snehal G. Patel
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Kristine M. Mosier
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Suzanne L. Wolden
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Andrei I. Holodny
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  • Fig 1.
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    Fig 1.

    The configuration of NPC is almost always asymmetric as seen in this contrast enhanced, axial T1 weighted fat saturation MRI image (TR = 400, TE = 10.3).

  • Fig 2.
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    Fig 2.

    Central skull base invasion. Note high signal in the left aspect of the clivus on this axial, T2 weighted fat saturation MRI image. (TR = 2000, TE = 105).

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    Fig 3.

    Tumor extending into and widening the right petroclival fissure (arrows). Soft tissue (A) and (B) bone windows CT neck with contrast.

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    Fig 4.

    Invasion of the right parapharyngeal space fat. Axial contrast enhanced neck CT.

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    Fig 5.

    Tumor extension into and widening of the right pterygopalatine fossa (arrow) seen on soft tissue window image (A) and three consecutive bone window images (B-D) CT neck with contrast.

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    Fig 6.

    Tumor invading the left masticator space. Axial T2 weighted fat saturation MRI image. (TR = 2000, TE = 105).

Tables

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    TABLE 1:

    Clinical characteristics of patients

    PatientAge(y)/SexPresenting SymptomTime to Diagnosis (mo)T Stage at DiagnosisN StageEpstein-Barr Virus Status
    113/FR neck mass3T4N3bPositive
    217/MPain right ear7T4N2NA
    316/FNANAT3N2NA
    416/MEpistaxis2T4N2Positive
    513/FR otitis media, neck mass4T4N2Negative
    612/MEpistaxis4T3N2Positive
    716/MNANAT4N1NA
    814/ML neck mass1T4N3bNA
    915/MR neck mass4T4N2Positive
    1015/ML neck mass, nasal stuffiness4T3N2NA
    1112/FR nece mass2T3N2NA
    • Note—NA = not available.

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    TABLE 2:

    Imaging features of NPCs

    PatientImagingNasal CavityLateral Retropharyngeal LymphadenopathyNeck NodesMastoid OpacificationPetroclival FissureSkull Base/Prevertebral MusclePterygopalatine FossaParapharyngeal SpaceMasticator SpaceCarotid EncasementCavernous SinusSphenoid Sinus
    1CT, MRInvolvedNIBilateralYesNIUnilateralUnilateralUnilateralNIYesInvolvedInvolved
    2CTPosterior choanaBilateralUnilateralYesBilateralUnilateralNIUnilateralNINoNIInvolved
    3CTNIUnilateralBilateralYesNIUnilateralNINININoNINI
    4MRPosterior choanaBilateralUnilateralYesUnilateralUnilateralNIUnilateralUnilateralNoNINI
    5CTInvolvedUnilateralUnilateralYesUnilateralUnilateralNIUnilateralNINoNINI
    6CT, MRPosterior choanaUnilateralBilateralYesUnilateralUnilateralNINININoNIInvolved
    7CTPosterior choanaUnilateralUnilateralYesUnilateralUnilateralUnilateralNIUnilateralNoNINI
    8CT, MRPosterior choanaUnilateralBilateralYesNIUnilateralNIUnilateralNINoNINI
    9MRNIUnilateralBilateralYesUnilateralUnilateralNIUnilateralNINoNINI
    10CT, MRPosterior choanaBilateralBilateralYesUnilateralUnilateralNINININoNINI
    11MRPosterior choanaBilateralBilateralBothBilateralUnilateralNINININoNINI
    • Note—NI = not involved.

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American Journal of Neuroradiology: 26 (6)
American Journal of Neuroradiology
Vol. 26, Issue 6
1 Jun 2005
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Cite this article
Hilda E. Stambuk, Snehal G. Patel, Kristine M. Mosier, Suzanne L. Wolden, Andrei I. Holodny
Nasopharyngeal Carcinoma: Recognizing the Radiographic Features in Children
American Journal of Neuroradiology Jun 2005, 26 (6) 1575-1579;

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Nasopharyngeal Carcinoma: Recognizing the Radiographic Features in Children
Hilda E. Stambuk, Snehal G. Patel, Kristine M. Mosier, Suzanne L. Wolden, Andrei I. Holodny
American Journal of Neuroradiology Jun 2005, 26 (6) 1575-1579;
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