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Research ArticleINTERVENTIONAL

Abciximab in Patients with Ruptured Intracranial Aneurysms

Richard I. Aviv, Richard O’Neill, Maneesh C. Patel and Iain R. Colquhoun
American Journal of Neuroradiology August 2005, 26 (7) 1744-1750;
Richard I. Aviv
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Richard O’Neill
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Maneesh C. Patel
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Iain R. Colquhoun
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Article Figures & Data

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    Fig 1.

    Anteroposterior oblique views, selective right ICA injection.

    A, Right PCOM aneurysm in association with fetal-type PCA after the insertion of six coils. Image shows minor projection of coils into the terminal ICA (arrow), which demonstrates spasm. Contrast material irregularly fills the proximal ACA, with nonvisualization of the distal ACA. These findings are consistent with thrombus (arrowhead).

    B, Immediately after the intravenous injection of abciximab 20 mg, the A1 segment of the ACA (arrowhead) is completely recanalized. Minor filling defect in the proximal A2 (arrow) dissipated shortly afterward.

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    Fig 2.

    Anteroposterior views.

    A and B, Selective right ICA injection after the insertion of three coils. Before abciximab treatment (A), thrombus is seen at the neck of the aneurysm (arrowhead) and in the proximal right A2 segment of the right anterior cerebral artery (arrow). After abciximab (B), improvement in both is noted.

    C and D, Selective injection after the insertion of five coils and aneurysm rupture. In C, thrombus (arrow) is present in the distal A1 segment and ACOM, with adjacent extravasation of contrast material (arrowhead). After heparin reversal, repeat angiogram in D demonstrates aneurysm occlusion, cessation of extravasation, and absence of thrombus, but marked vasospasm is present.

Tables

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  • Patient Demographic Data

    Age (years)/SexSiteSize (mm)WFNS Grade at PresentationProximal/Distal ThrombosisAneurysm Occluded/(%)/No of Coils before Cx/Further CoilsAbciximab Dose/RouteAngiographic ResponseDeficit or Complication/GOSGOS
    56/FACOM5.7 × 3.51PNo (80%)/3/25mg Abciximab IV, 500mg aspirin IVComplete, immediateRupture6
    68/MACOM5 × 31PYes/5/05mg Abciximab IV, 30mg Papavarine IAComplete, immediateNone1
    27/FPCOM98 × 81PYes/5/05mg Abciximab IVPartial, immediateNone1
    63/MACOM6.5 × 7.52PYes/4/020mg of Abciximab IV,500mg aspirin IVPartial,immediateShunt/haematomaevacuation4
    72/FPCOM2.2 × 3 × 22DNo (0%)/0/45mg Abciximab x2 IV,direct agitation ofbasilar thrombusPartial,immediateCerebellarinfarct1
    52/MACOM7 × 51PNo (60%)/4/05mg Abciximab IV ×2,500mg aspirin IVComplete,immediateNone1
    59/MBasilar tip12 × 12 × 105DNo (20%)/6/010mg Abciximab IVComplete,immediatePCA infarct1
    79/FACOM7 × 5.4 × 6.71DYes/4/07.5mg Abciximab IVComplete,immediateRightACAinfarct1
    51/FPCOM6.3 × 6 × 75 to 2P, DYes/13/0Abciximab 5mg IVComplete,immediateNone1
    70/MMCA5 × 42DYes/4/05mg Abciximab IV,40mg Papavarine IA,5mg Abciximab IV,30mg Papavarine IAPartial aftersecondAbciximabdoseTransienthemiparesis1
    52/FPCOM15 × 141PNo (90%)/13/3500mg aspirin IV,Abciximab 5mg IVComplete,immediateTransienthemiparesis/dysphasia1
    46/FPICA2 × 5 × 21PYes/2/0Abciximab 5mg IV/500 mg aspirin IVNA/prophylaxisNone1
    29/FPCOM9 × 7.62PYes/6/0Abciximab 5mg IVComplete,immediateTransient lefthemiparesis1
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American Journal of Neuroradiology: 26 (7)
American Journal of Neuroradiology
Vol. 26, Issue 7
1 Aug 2005
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Cite this article
Richard I. Aviv, Richard O’Neill, Maneesh C. Patel, Iain R. Colquhoun
Abciximab in Patients with Ruptured Intracranial Aneurysms
American Journal of Neuroradiology Aug 2005, 26 (7) 1744-1750;

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Abciximab in Patients with Ruptured Intracranial Aneurysms
Richard I. Aviv, Richard O’Neill, Maneesh C. Patel, Iain R. Colquhoun
American Journal of Neuroradiology Aug 2005, 26 (7) 1744-1750;
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  • Intra-arterial versus intravenous abciximab therapy for thromboembolic complications of neuroendovascular procedures: case review and meta-analysis
  • Rescue Treatment of Thromboembolic Complications during Endovascular Treatment of Cerebral Aneurysms: A Meta-Analysis
  • Rescue Treatment of Thromboembolic Complications During Endovascular Treatment of Cerebral Aneurysms
  • Adjunctive use of eptifibatide for complication management during elective neuroendovascular procedures
  • Intra-arterial abciximab for the treatment of thrombus formation during coil embolization of intracranial aneurysms
  • Clinical and Angiographic Follow-up of Ruptured Intracranial Aneurysms Treated with Endovascular Embolization
  • Abciximab Is a Safe Rescue Therapy in Thromboembolic Events Complicating Cerebral Aneurysm Coil Embolization: Single Center Experience in 42 Cases and Review of the Literature
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