Article Figures & Data
Figures
- Fig 1.
A 61-year-old male patient with right hemiparesis imaged at 2.3 hours and 3 days. Abnormal areas are outlined on CBV (A), CBF (B), and follow-up CT (C) images. After coregistration, we defined 3 regions on CBF maps (D): region 1 (red), “infarct core”—abnormal on CBV, CBF, and follow-up CT images; region 2 (blue), “penumbra that infarcts”—normal on CBV but abnormal on CBF and follow-up CT images; and region 3 (green) “penumbra that recovers”—abnormal on CBF but normal on CBV and follow-up CT images.
- Fig 2.
Box and Whisker graphs of normalized CBV (A) and CBF ratios (B) in regions 1–3.
- Fig 3.
Box and Whisker graphs of mean GM and WM quantitative CBF values for each patient in regions 2 and 3.
Tables
Patient No./Sex/Age (y) Admission NIHSS Time to CTP (h) Occ Site Time to trtmnt (h) Therapy Time to F/U (d) Mori Scale mRS at Discharge CBF ratio Reg 1 CBF ratio Reg 2 CBF ratio Reg 3 CBV ratio Reg 1 CBV ratio Reg 2 CBV ratio Reg 3 1/F/80 27 1.7 M1 3.5 IA rtPA 12 2 4 0.10 0.29 0.44 0.38 0.56 0.69 2/F/81 15 3.7 M1 4 Mechanical 1 4 2 0.16 0.25 0.40 0.51 0.88 1.04 3/F/74 10 2.1 M1 3.3 IV + IA rtPA 5 3 2 0.12 0.30 0.34 0.31 0.68 0.88 4/F/74 18 1.2 ICA 3.5 IA rtPA 7 2 3 0.28 0.33 0.49 0.52 0.70 0.70 5/F/81 25 0.9 ICA 2 IA rtPA 4 1 4 0.27 0.39 0.63 0.50 0.83 1.18 6/F/69 22 4.8 M2 6 IV rtPA + Mechanical 3 0 2 0.19 0.25 0.32 0.58 1.16 1.09 7/M/77 9 0.9 M1 3.3 IV + IA rtPA 5 3 1 0.25 0.39 0.46 0.50 0.70 0.68 8/M/61 11 2.3 ICA, MI 4.4 IA rtPA 3 4 1 0.20 0.32 0.36 0.65 1.08 1.05 9/M/46 20 3.3 M1 3.2 IV rtPA + IA rtPA 3 1 6 0.26 0.40 0.55 0.48 0.91 1.22 10/F/44 13 1.7 M1 3 IV rtPA + IA rtPA 5 4 0 0.17 0.25 0.52 0.44 0.81 0.91 11/F/82 16 2.4 M1 4.3 Mechanical 3 2 6 NP 0.40 NP NP 0.68 NP 12/F/71 19 5.4 ICA 7 Mechanical 5 1 4 0.20 0.34 0.50 0.51 1.03 1.07 13/M/75 6 3.8 M2 5.5 Mechanical 3 0 2 0.18 0.39 NP 0.45 0.81 NP 14/F/71 19 2.4 ICA 3.6 IA rtPA 1 2 6 0.13 0.44 0.48 0.39 0.91 0.99 Note:— CTP indicates computed tomography perfusion; F/U, follow-up; mechanical, clot disruption/retrieval; NP, region not present; mRS, modified Rankin Score; trtmnt, treatment; reg, region; pt, patient; occ, occlusion.
Parameter Region 1 Mean Ratio ± SD Region 2 Mean Ratio ± SD Region 3 Mean Ratio ± SD P Value (Region 1 vs 2) P Value (Region 2 vs 3) CBV ratio 0.48 ± 0.09 0.84 ± 0.17 0.96 ± 0.19 <0.0001 0.03 CBF ratio 0.19 ± 0.06 0.34 ± 0.06 0.46 ± 0.09 <0.0001 <0.0001 CBV value (ml/100 g) 1.47 ± 0.4 2.83 ± 0.67 2.94 ± 0.45 <0.0001 0.05 CBF value (ml/100 g/min) 8.88 ± 2.3 16.08 ± 5.71 17.92 ± 4.0 <0.0001 0.1 Note:— CBF indicates cerebral blood flow; CBV, cerebral blood volume.
- Table 3:
CTP absolute values for penumbra that infarcts (region 2) and penumbra that recovers (region 3) in gray and white matter
Region 2 Mean ratio ± SD Region 3 Mean ratio ± SD P Value GM CBV (ml/100 g) 3.54 ± 1.33 3.87 ± 0.61 0.34 WM CBV (ml/100 g) 2.64 ± 1.38 2.27 ± 0.93 0.46 GM CBF (ml/100 g/min) 17.17 ± 8.67 27.22 ± 9.74 0.01 WM CBF (ml/100 g/min) 10.12 ± 4.77 14.01 ± 7.61 0.06 Note:— CBF indicates cerebral blood flow; CBV, cerebral blood volume; GM, gray matter; WM, white matter.
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