Research ArticleBrain
MR Imaging of Relapsing Multiple Sclerosis Patients Using Ultra-Small-Particle Iron Oxide and Compared with Gadolinium
V. Dousset, B. Brochet, M.S.A. Deloire, L. Lagoarde, B. Barroso, J.-M. Caille and K.G. Petry
American Journal of Neuroradiology May 2006, 27 (5) 1000-1005;
V. Dousset
B. Brochet
M.S.A. Deloire
L. Lagoarde
B. Barroso
J.-M. Caille

References
- ↵
- ↵Kornek B, Lassmann H. Neuropathology of multiple sclerosis—new concepts. Brain Res Bull 2003;61:321–26
- ↵Lucchinetti C, Brück W, Noseworthy J. Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment. Curr Opin Neurol 2001;14:259–69
- ↵Noseworthy JH, Lucchinetti C, Rodriguez M, et al. Multiple sclerosis. N Engl J Med 2000;343:938–52
- ↵Brück W, Porada P, Poser S, et al. Monocyte/macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 1995;38:788–96
- ↵Miller DH, Grossman RI, Reingold SC, et al. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 1998;121:3–24
- ↵Filippi M, Grossman RI. MRI techniques to monitor MS evolution. The present and the future. Neurology 2002;58:1147–53
- ↵Grossman RI, Braffman BH, Brorson JR, et al. Multiple sclerosis: serial study of gadolinium-enhanced MR imaging. Radiology 1988;169:117–22
- ↵Barnes D, Munro PM, Youl BD, et al. The longstanding MS lesion. A quantitative MRI and electron microscopic study. Brain 1991;114:1271–80
- ↵Narayana PA, Doyle TJ, Lai D, et al. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998;43:56–71
- ↵Kappos L, Moeri D, Radue EW, et al. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI meta-analysis group. Lancet 1999;353:964–69
- ↵Lassmann H, Bruck W, Lucchinetti C. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 2001;7:115–21
- ↵Dousset V, Delalande C, Ballarino L, et al. In vivo macrophage activity imaging in the central nervous system detected by magnetic resonance. Magn Reson Med 1999;41:329–33
- ↵Dousset V, Ballarino L, Delalande C, et al. Comparison of ultrasmall particles of iron oxide (USPIO) T2-weighted, conventional T2-weighted and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis. AJNR Am J Neuroradiol 1999;20:223–27
- ↵Rausch M, Hiestand P, Baumann D, et al. MRI-based monitoring of inflammation and tissue damage in acute and chronic relapsing EAE. Magn Reson Med 2003;50:309–14
- Deloire MS, Touil T, Brochet B, et al. Macrophage brain infiltration in experimental autoimmune encephalomyelitis is not completely compromised by suppressed T-cell invasion: in vivo magnetic resonance imaging illustration in effective anti-VLA-4 antibody treatment. Mult Scler 2004;10:540–48
- ↵Floris S, Blezer ELA, Schreibelt G, et al. Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis. A quantitative study. Brain 2004;127:616–27
- ↵Pirko I, Johnson A, Ciric B, et al. In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies. FASEB 2004;18:179–81
- ↵Weissleder R, Elizondo G, Wittenberg J, et al. Ultrasmall superparamagnetic iron oxide: characterization of a new class contrast agents for MR imaging. Radiology 1990;175:494–98
- ↵Moore A, Weissleder R, Bogdanov A. Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages. J Magn Reson Imaging 1997;7:1140–45
- ↵Rausch M, Sauter A, Fröhlich J, et al. Dynamic patterns of USPIO enhancement can be observed in macrophages after ischemic brain damage. Magn Reson Med 2001;46:1018–22
- Ruehm SG, Corot C, Vogt P, et al. Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation 2001;103:415–22
- ↵Schroeter M, Saleh A, Wiedermann D, et al. Histochemical detection of ultrasmall superparamagnetic iron oxide (USPIO) contrast medium uptake in experimental brain ischemia. Mag Reson Med 2004;52:403–06
- ↵Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques to monitor the treatment of multiple sclerosis. Ann Neurol 1996;39:6–16
- ↵
- ↵Wekerle H. Immunology of multiple sclerosis. In: Compston A, ed. McAlpine’s multiple sclerosis. 3rd ed. London: Churchill Livingstone;1998 :379–407
- ↵Martin R, McFarland H. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit Rev Clin Lab Sci 1995;32:121–82
- ↵Genain CP, Canella B, Hauser SL, et al. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat Med 1999;5:170–75
- ↵Lucchinetti CF, Brück W, Parisi J, et al. Heterogeneity of multiple sclerosis lesions; implications for the pathogenesis of demyelination. Ann Neurol 2000;47:707–17
- ↵Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions (“black holes”) on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 1996;47:1469–76
- ↵Miki Y, Grossman RI, Udupa JK, et al. Differences between relapsing-remitting and chronic progressive multiple sclerosis as determined with quantitative MR imaging. Radiology 1999;210:769–74
- ↵Enochs WS, Harsh G, Hochberg F, et al. Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent. J Magn Reson Imaging 1999;9:228–32
- ↵Saleh A, Schroeter M, Jonkmanns C, et al. In vivo MRI of brain inflammation in human ischaemic stroke. Brain 2004;127:1670–77
- ↵Daldrup-Link HE, Rudelius M, Oostendorp RAJ, et al. Targeting of hematopoietic progenitor cells with MR contrast agents. Radiology 2003;228:760–67
- ↵Zimmer C, Weissleder R, Poss K, et al. MR imaging of phagocytosis in experimental gliomas. Radiology 1995;197:533–38
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V. Dousset, B. Brochet, M.S.A. Deloire, L. Lagoarde, B. Barroso, J.-M. Caille, K.G. Petry
MR Imaging of Relapsing Multiple Sclerosis Patients Using Ultra-Small-Particle Iron Oxide and Compared with Gadolinium
American Journal of Neuroradiology May 2006, 27 (5) 1000-1005;
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