Article Figures & Data
Figures
- Fig 1.
Illustration of the application of the Cavalieri method to estimate hippocampal volume.
- Fig 2.
Illustration of the point-counting technique applied to estimate hippocampal volume from MR images of a control (C, top row), patient with left-sided seizure onset (LP, second row), and patient with right-sided seizure onset (RP, bottom row).
- Fig 3.
Illustration of the boundaries of the hippocampus. The splitting of the lateral ventricles form the posterior border (108, Split LV), and the alveus forms the anterior border (150).
- Fig 4.
Empirical probability distributions and Q-Q plots for the right and left volume and asymmetry index of the hippocampus of the control population.
- Fig 5.
Left and right hippocampal volume estimate (left panel) and hippocampal volume asymmetry index (right panel) for controls and patients with TLE. The dashed lines represent the 99% prediction lower bounds for the left and right hippocampal volume estimate (left panel) and the 99% prediction interval for the hippocampal volume asymmetry index (right panel). The proportion of patients showing abnormal hippocampal volume is indicated in parentheses.
- Fig 6.
Left hippocampal volume versus right hippocampal volume in R-patients (top left panel), L-patients (top right panel), and controls (bottom panel). The dashed lines represent the 99% lower bounds for the right and left hippocampal volume obtained from the control data.
Tables
Controls Left-Sided Seizure Onset Right-Sided Seizure Onset Mean age, y (SD) 33 (10.4) 34 (8.4) 34 (9.7) Sex (%) M 25 (50) 24 (45.3) 20 (42) F 25 (50) 29 (55.7) 28 (58) Handedness (%) Right 42 (87.5) 40 (80) 43 (91.5) Left 6 (12.5) 10 (20) 4 (8.5) Not established 2 3 1 Mean onset, y (SD) 10.6 (9) 10.4 (8) Febrile convulsiosn (%) Yes 18 (45) 15 (36.6) No 22 (55) 26 (63.4) Not recorded 13 7 - Table 2:
Classification of hippocampal atrophy in 101 patients with temporal lobe epilepsy
Patients with right-sided seizure onset (n = 48) No evidence of HA 10 (21%) Unilateral HA 34 (71%) Right HA 31 (65%) Left HA 1 (2%) Only asymmetry (right ≪ left) 2 (4%) Bilateral HA 4 (8%) Patients with left-sided seizure onset (n = 53) No evidence of HA 9 (17%) Unilateral HA 43 (81%) Right HA 0 (0%) Left HA 38 (72%) Only asymmetry (right ≪ left) 5 (9%) Bilateral HA 1 (2%) Note:—Laterality of seizure onset was established using electroencephalogram recordings or invasive foramen ovale. HA indicates hippocampal atrophy.
