Article Figures & Data
Figures
- Fig 1.
Neuronal cell loss in the ventral hippocampus and the parietal cortex 2 weeks after status epilepticus compared with control animals. Note drastically reduced neuronal attenuation in the CA1 region of the ventral hippocampus (vCA1) and, to a lesser extent, in the parietal cortex (PaCor) at 2 weeks. Arrows in higher magnifications point at CA1 neuronal cell layers displaying reduced neuronal attenuation and swollen or pyknotic cells as signs of ongoing neuronal degeneration.
- Fig 2.
Regions of interest (ROIs) used for quantitative apparent diffusion coefficient analysis.
A, Representative diffusion-weighted MR image on which ROIs are outlined.
B, Schematic drawing of a rat brain at similar level with identical ROIs superimposed. ROIs were defined as: retrosplenial parietal and temporal cortex (RCp and RCt), pyriform cortex (PC), hippocampus (Hippo), thalamus (Thal), and amygdala (Amy).
- Fig 3.
Averaged apparent diffusion coefficients in the retrosplenial parietal, temporal, and pyriform (basal) cortex, the thalamus, amygdala, and hippocampus of pilocarpine-treated animals before and within 120 minutes after pilocarpine-induced status epilepticus; ∗ indicates P < 0.05 compared to baseline.
Tables
Rates of neuronal degeneration
0.5 hours 2 hours 24 hours 1 week 2 weeks Parietal cortex 99 ± 9% 101 ± 5% 81 ± 7% 78 ± 5% 75 ± 9% Temporal cortex 98 ± 6% 93 ± 7% 67 ± 3% 71 ± 5% 58 ± 10% Pyriform cortex 93 ± 7% 90 ± 7% 47 ± 3% 52 ± 12% 32 ± 4% Thalamus 96 ± 4% 100 ± 9% 62 ± 4% 61 ± 3% 44 ± 3% Amygdala 97 ± 4% 101 ± 10% 66 ± 3% 54 ± 6% 38 ± 5% Hippocampus (CA1 + 2) 103 ± 5% 97 ± 7% 70 ± 4% 63 ± 10% 52 ± 18% Hippocampus (CA3) 99 ± 3% 103 ± 8% 76 ± 3% 64 ± 11% 46 ± 20% Note:—Neuronal cell loss in diverse brain regions at different time points after status epilepticus. Values are numbers of surviving neurons given as a percentage of neurons in control animals. All values at 24 hours, 1 week, and 2 weeks were statistically significant (P < .05).
