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Research ArticleINTERVENTIONAL

Diagnostic Accuracy of 3D Time-of-Flight MR Angiography Compared with Digital Subtraction Angiography for Follow-Up of Coiled Intracranial Aneurysms: Influence of Aneurysm Size

H.A. Deutschmann, M. Augustin, J. Simbrunner, B. Unger, H. Schoellnast, G.A. Fritz and G.E. Klein
American Journal of Neuroradiology April 2007, 28 (4) 628-634;
H.A. Deutschmann
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M. Augustin
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J. Simbrunner
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B. Unger
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H. Schoellnast
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G.A. Fritz
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G.E. Klein
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  • Fig 1.
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    Fig 1.

    Agreement in detection of residual flow at the neck of an aneurysm of the anterior cerebral artery after treatment with detachable coils seen on DSA (A, black arrow). Unenhanced 3D TOF MRA (B) and MIP reconstruction (C) showing the residual flow (white arrows) in agreement with DSA.

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    Fig 2.

    Overestimation of a completely occluded aneurysm of the anterior communicating artery seen on DSA (A, black arrow). Unenhanced 3D TOF MR angiography (B) and MIP reconstruction (C) showing a small residual perfusion at the neck of the aneurysm (white arrows).

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    Fig 3.

    Overestimation of a small residual perfusion of a coiled aneurysm of the middle cerebral artery seen on DSA (A, black arrow). Contrast-enhanced 3D TOF MRA (B) and MIP reconstruction (C) showing a large residual neck (white arrows).

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    Fig 4.

    Underestimation of a residual perfusion of the neck of a basilaris tip aneurysm seen on DSA (A, black arrow). Contrast-enhanced TOF MRA (B) and MIP reconstruction (C) showing complete occlusion (white arrows).

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    Fig 5.

    Underestimation of a large residual neck of an aneurysm of the anterior communicating artery seen on DSA (A, black arrow). Unenhanced TOF MRA (B) shows a small residual perfusion of the aneurysm neck (white arrow).

Tables

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    Table 1:

    MRA and DSA findings in 193 aneurysms treated with detachable coils

    MRA FindingDSA Finding
    Large Residual NeckSmall Residual NeckComplete OcclusionNot AssessableTotal
    Large residual neck21104
    Small residual neck1508059
    Complete occlusion071180125
    Not assessable02305
    Total3601300193
    • Note:—MRA indicates magnetic resonance angiography; DSA, digital subtraction angiography.

    • View popup
    Table 2:

    MRA and DSA findings with regard to aneurysm location

    MRA FindingsDSA Findings
    Residual NeckComplete Occlusion
    ICA
        Residual neck121
        Complete occlusion126
        Percentage92.3 (68–99)96 (80–99)
    AcomA
        Residual neck186
        Complete occlusion140
        Percentage94.7 (74–99)87 (74–95)
    ACA
        Residual neck10
        Complete occlusion06
        Percentage100 (3–100)100 (5–100)
    MCA
        Residual neck71
        Complete occlusion018
        Percentage100 (54–100)95 (75–99)
    BA
        Residual neck101
        Complete occlusion210
        Percentage83.3 (52–98)90.9 (59–99)
    PcomA
        Residual neck50
        Complete occlusion315
        Percentage62.5 (18–90)100 (79–100)
    PICA
        Residual neck10
        Complete occlusion02
        Percentage100 (3–100)100 (16–100)
    VA
        Residual neck00
        Complete occlusion01
        Percentage100 (3–100)
    Total
        Residual neck549
        Complete occlusion7118
        Percentage88.5 (78–95)92.9 (87–97)
    • Note:—MRA indicates magnetic resonance angiography; DSA, digital subtraction angiography; ICA, internal carotid artery; AcomA, anterior communicating artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; BA, basilar artery; PcomA, posterior communicating artery; PICA, posterior inferior cerebellar artery; VA, vertebral artery. Percentages represent sensitivity (left column) and specificity (right column); figures in parentheses are 95% confidence intervals.

    • View popup
    Table 3:

    Possible causes for disagreement between TOF MRA and DSA in 16 patients

    LocationN (%)Size (mean, mm)Overestimation (Size)Underestimation (Size)
    ICA40 (21.3)10.4Vessel overlap (9 mm)Pulsation-induced artifacts (10 mm)
    AcomA65 (34.6)5.7Vessel overlap (8 mm)Susceptibility at bone/air interface (2.5 mm)
    Vessel overlap and small size (2 mm, 3 mm)
    Partially thrombosed aneurysm (10 mm)
    Pulsation-induced artifacts (2 mm, 12 mm)
    ACA7 (3.7)9.1
    MCA26 (13.8)7.1Vessel overlap (11 mm)
    BA23 (12.2)7.6Pulsation-induced artifacts (10 mm)Slow flow and small size (2 mm)
    Saturation effects and small size (3 mm)
    PcomA23 (12.2)7.3Vessel overlap (10 mm)
    Signal void due to slow flow (5 mm)
    Susceptibility at bone/air interface (3 mm)
    PICA3 (1.7)6.7
    VA1 (0.5)4.0
    Total188 (100)7.5
    • Note:—MRA indicates magnetic resonance angiography; DSA, digital subtraction angiography; ICA, internal carotid artery; AcomA, anterior communicating artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; BA, basilar artery; PcomA, posterior communicating artery; PICA, posterior inferior cerebellar artery; VA, vertebral artery.

    • View popup
    Table 4:

    Findings of 3D TOF MRA and DSA with regard to aneurysm size

    MRA FindingDSA Finding
    Residual NeckComplete Occlusion
    Aneurysms ≤ 3 mm
        Residual neck73
        Complete occlusion419
        Percentage63.6 (31–89)86.4 (65–97)
    Aneurysms >3 mm
        Residual neck476
        Complete occlusion399
        Percentage94 (84–99)94.3 (88–98)
        Residual neck476
    Aneurysms ≤ 5 mm
        Residual neck133
        Complete occlusion552
        Percentage72.2 (62–82)94.5 (89–100)
    Aneurysms > 5 mm
        Residual neck416
        Complete occlusion266
        Percentage95.3 (84–99)91.7 (83–97)
    • Note:—TOF indicates time of flight; MRA, magnetic resonance angiography; DSA, digital subtraction angiography. Percentages represent sensitivity (left column) and specificity (right column); figures in parentheses are 95% confidence intervals.

    • View popup
    Table 5:

    Findings of unenhanced and contrast-enhanced 3D TOF MRA compared with DSA

    MRA FindingDSA Finding
    Residual NeckComplete Occlusion
    Unenhanced MRA
        Residual neck244
        Complete occlusion346
        Percentage88.9 (70.1–97.6)92 (80.8–97.7)
    Contrast-enhanced MRA
        Residual neck305
        Complete occlusion472
        Percentage88.2 (72.6–96.7)93.5 (85.5–97.7)
    • Note:—TOF indicates time of flight; MRA, magnetic resonance angiography; DSA, digital subtraction angiography. Percentages represent sensitivity (left column) and specificity (right column); figures in parentheses are 95% confidence intervals.

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American Journal of Neuroradiology: 28 (4)
American Journal of Neuroradiology
Vol. 28, Issue 4
April 2007
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H.A. Deutschmann, M. Augustin, J. Simbrunner, B. Unger, H. Schoellnast, G.A. Fritz, G.E. Klein
Diagnostic Accuracy of 3D Time-of-Flight MR Angiography Compared with Digital Subtraction Angiography for Follow-Up of Coiled Intracranial Aneurysms: Influence of Aneurysm Size
American Journal of Neuroradiology Apr 2007, 28 (4) 628-634;

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Diagnostic Accuracy of 3D Time-of-Flight MR Angiography Compared with Digital Subtraction Angiography for Follow-Up of Coiled Intracranial Aneurysms: Influence of Aneurysm Size
H.A. Deutschmann, M. Augustin, J. Simbrunner, B. Unger, H. Schoellnast, G.A. Fritz, G.E. Klein
American Journal of Neuroradiology Apr 2007, 28 (4) 628-634;
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  • Residual Flow After Cerebral Aneurysm Coil Occlusion: Diagnostic Accuracy of MR Angiography
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  • MR Angiographic Follow-Up of Intracranial Aneurysms Treated with Detachable Coils: Evaluation of a Blood-Pool Contrast Medium
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