Research ArticlePediatric Neuroimaging
Differentiating Normal Myelination from Hypoxic-Ischemic Encephalopathy on T1-Weighted MR Images: A New Approach
L. Liauw, I.H. Palm-Meinders, J. van der Grond, L.M. Leijser, S. le Cessie, L.A.E.M. Laan, B.C. Heeres, M.A. van Buchem and G. van Wezel-Meijler
American Journal of Neuroradiology April 2007, 28 (4) 660-665;
L. Liauw
I.H. Palm-Meinders
J. van der Grond
L.M. Leijser
S. le Cessie
L.A.E.M. Laan
B.C. Heeres
M.A. van Buchem

References
- ↵Johnson MA, Pennock JM, Bydder GM, et al. Serial MR imaging in neonatal cerebral injury. AJNR Am J Neuroradiol 1987;8:83–92
- McArdle CB, Richardson CJ, Hayden CK, et al. Abnormalities of the neonatal brain: MR imaging. Part II. Hypoxic-ischemic brain injury. Radiology 1987;163:395–403
- ↵Barkovich AJ, Truwit CL. Brain damage from perinatal asphyxia: correlation of MR findings with gestational age. AJNR Am J Neuroradiol 1990;11:1087–96
- ↵Barkovich AJ. MR and CT evaluation of profound neonatal and infantile asphyxia. AJNR Am J Neuroradiol 1992;13:959–72
- Baenziger O, Martin E, Steinlin M, et al. Early pattern recognition in severe perinatal asphyxia: a prospective MRI study. Neuroradiology 1993;35:437–42
- van der Knaap MS, Smit LS, Nauta JJ, et al. Cortical laminar abnormalities: occurrence and clinical significance. Neuropediatrics 1993;24:143–48
- ↵Rutherford MA, Pennock JM, Dubowitz LM. Cranial ultrasound and magnetic resonance imaging in hypoxic-ischaemic encephalopathy: a comparison with outcome. Dev Med Child Neurol 1994;36:813–25
- Barkovich AJ, Westmark K, Partridge C, et al. Perinatal asphyxia: MR findings in the first 10 days. AJNR Am J Neuroradiol 1995;16:427–38
- ↵Barkovich AJ, Sargent SK. Profound asphyxia in the premature infant: imaging findings. AJNR Am J Neuroradiol 1995;16:1837–46
- Rademakers RP, van der Knaap MS, Verbeeten B Jr, et al. Central cortico-subcortical involvement: a distinct pattern of brain damage caused by perinatal and postnatal asphyxia in term infants. J Comput Assist Tomogr 1995;19:256–63
- Rutherford MA, Pennock JM, Schwieso JE, et al. Hypoxic ischaemic encephalopathy: early magnetic resonance imaging findings and their evolution. Neuropediatrics 1995;26:183–91
- ↵Rutherford M, Pennock J, Schwieso J, et al. Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child Fetal Neonatal Ed 1996;75:F145–51
- ↵Rutherford MA, Pennock JM, Counsell SJ, et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics 1998;102:323–28
- ↵Barkovich AJ. Brain and spine injuries in infancy and childhood. In: Barkovich AJ, ed. Pediatric Neuroimaging, 4th ed. Philadelphia: Lippincott, Williams & Wilkins;2005 :190–290
- Sie LT, van der Knaap MS, Wezel-Meijler G, et al. Early MR features of hypoxic-ischemic brain injury in neonates with periventricular densities on sonograms. AJNR Am J Neuroradiol 2000;21:852–61
- ↵
- ↵Miller SP, Ramaswamy V, Michelson D, et al. Patterns of brain injury in term neonatal encephalopathy. J Pediatr 2005;146:453–60
- ↵Rutherford MA. The asphyxiated term infant. In: Rutherford MA, ed. MRI of the Neonatal Brain. London, UK: WB Saunders;2002 :99–128
- ↵Holland BA, Haas DK, Norman D, et al. MRI of normal brain maturation. AJNR Am J Neuroradiol 1986;7:201–08
- Barkovich AJ, Kjos BO, Jackson DE Jr, et al. Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 1988;166:173–80
- Martin E, Kikinis R, Zuerrer M, et al. Developmental stages of human brain: an MR study. J Comput Assist Tomogr 1988;12:917–22
- ↵Bird CR, Hedberg M, Drayer BP, et al. MR assessment of myelination in infants and children: usefulness of marker sites. AJNR Am J Neuroradiol 1989;10:731–40
- Dietrich RB. Magnetic resonance imaging of normal brain maturation. Semin Perinatol 1990;14:201–11
- Sie LT, van der Knaap MS, Wezel-Meijler G, et al. MRI assessment of myelination of motor and sensory pathways in the brain of preterm and term-born infants. Neuropediatrics 1997;28:97–105
- ↵Barkovich AJ. Normal development of the neonatal and infant brain, skull, and spine. In: Barkovich AJ, ed. Pediatric Neuroimaging, 4th ed. Philadelphia: Lippincott, Williams & Wilkins;2005 :17–75
- ↵Barkovich AJ, Westmark KD, Bedi HS, et al. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report. AJNR Am J Neuroradiol 2001;22:1786–94
- Cowan FM, Pennock JM, Hanrahan JD, et al. Early detection of cerebral infarction and hypoxic ischemic encephalopathy in neonates using diffusion-weighted magnetic resonance imaging. Neuropediatrics 1994;25:172–75
- Inder T, Huppi PS, Zientara GP, et al. Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques. J Pediatr 1999;134:631–34
- Phillips MD, Zimmerman RA. Diffusion imaging in pediatric hypoxic ischemia injury. Neuroimaging Clin N Am 1999;9:41–52
- Rutherford M, Counsell S, Allsop J, et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics 2004;114:1004–14
- ↵Hanrahan JD, Sargentoni J, Azzopardi D, et al. Cerebral metabolism within 18 hours of birth asphyxia: a proton magnetic resonance spectroscopy study. Pediatr Res 1996;39:584–90
- Penrice J, Cady EB, Lorek A, et al. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia. Pediatr Res 1996;40:6–14
- Holshouser BA, Ashwal S, Luh GY, et al. Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children. Radiology 1997;202:487–96
- Barkovich AJ, Baranski K, Vigneron D, et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol 1999;20:1399–405
- ↵Maneru C, Junque C, Bargallo N, et al. (1)H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia. Neurology 2001;57:1115–18
- ↵Burdette JH, Ricci PE, Petitti N, et al. Cerebral infarction: time course of signal intensity changes on diffusion-weighted MR images. AJR Am J Roentgenol 1998;171:791–95
- ↵van der Knaap MS, Valk J. Myelination and retarded myelination. In: van der Knaap MS, Valk J, eds. Magnetic Resonance of Myelin, Myelination, and Myelin Disorders. Berlin, Germany: Springer-Verlag;1989 :26–29
- ↵Cowan FM. Magnetic resonance imaging of the normal infant brain: term to 2 years. In: Rutherford MA, ed. MRI of the Neonatal Brain. London, UK: WB Saunders;2002 :51–81
- ↵Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol 1976;33:696–705
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L. Liauw, I.H. Palm-Meinders, J. van der Grond, L.M. Leijser, S. le Cessie, L.A.E.M. Laan, B.C. Heeres, M.A. van Buchem, G. van Wezel-Meijler
Differentiating Normal Myelination from Hypoxic-Ischemic Encephalopathy on T1-Weighted MR Images: A New Approach
American Journal of Neuroradiology Apr 2007, 28 (4) 660-665;
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Differentiating Normal Myelination from Hypoxic-Ischemic Encephalopathy on T1-Weighted MR Images: A New Approach
L. Liauw, I.H. Palm-Meinders, J. van der Grond, L.M. Leijser, S. le Cessie, L.A.E.M. Laan, B.C. Heeres, M.A. van Buchem, G. van Wezel-Meijler
American Journal of Neuroradiology Apr 2007, 28 (4) 660-665;
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