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Research ArticlePediatric Neuroimaging

Differentiating Normal Myelination from Hypoxic-Ischemic Encephalopathy on T1-Weighted MR Images: A New Approach

L. Liauw, I.H. Palm-Meinders, J. van der Grond, L.M. Leijser, S. le Cessie, L.A.E.M. Laan, B.C. Heeres, M.A. van Buchem and G. van Wezel-Meijler
American Journal of Neuroradiology April 2007, 28 (4) 660-665;
L. Liauw
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I.H. Palm-Meinders
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J. van der Grond
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L.M. Leijser
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S. le Cessie
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L.A.E.M. Laan
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B.C. Heeres
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M.A. van Buchem
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G. van Wezel-Meijler
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References

  1. ↵
    Johnson MA, Pennock JM, Bydder GM, et al. Serial MR imaging in neonatal cerebral injury. AJNR Am J Neuroradiol 1987;8:83–92
    Abstract/FREE Full Text
  2. McArdle CB, Richardson CJ, Hayden CK, et al. Abnormalities of the neonatal brain: MR imaging. Part II. Hypoxic-ischemic brain injury. Radiology 1987;163:395–403
    PubMedWeb of Science
  3. ↵
    Barkovich AJ, Truwit CL. Brain damage from perinatal asphyxia: correlation of MR findings with gestational age. AJNR Am J Neuroradiol 1990;11:1087–96
    Abstract/FREE Full Text
  4. ↵
    Barkovich AJ. MR and CT evaluation of profound neonatal and infantile asphyxia. AJNR Am J Neuroradiol 1992;13:959–72
    Abstract/FREE Full Text
  5. Baenziger O, Martin E, Steinlin M, et al. Early pattern recognition in severe perinatal asphyxia: a prospective MRI study. Neuroradiology 1993;35:437–42
    CrossRefPubMedWeb of Science
  6. van der Knaap MS, Smit LS, Nauta JJ, et al. Cortical laminar abnormalities: occurrence and clinical significance. Neuropediatrics 1993;24:143–48
    PubMed
  7. ↵
    Rutherford MA, Pennock JM, Dubowitz LM. Cranial ultrasound and magnetic resonance imaging in hypoxic-ischaemic encephalopathy: a comparison with outcome. Dev Med Child Neurol 1994;36:813–25
    PubMedWeb of Science
  8. Barkovich AJ, Westmark K, Partridge C, et al. Perinatal asphyxia: MR findings in the first 10 days. AJNR Am J Neuroradiol 1995;16:427–38
    Abstract
  9. ↵
    Barkovich AJ, Sargent SK. Profound asphyxia in the premature infant: imaging findings. AJNR Am J Neuroradiol 1995;16:1837–46
    Abstract
  10. Rademakers RP, van der Knaap MS, Verbeeten B Jr, et al. Central cortico-subcortical involvement: a distinct pattern of brain damage caused by perinatal and postnatal asphyxia in term infants. J Comput Assist Tomogr 1995;19:256–63
    PubMedWeb of Science
  11. Rutherford MA, Pennock JM, Schwieso JE, et al. Hypoxic ischaemic encephalopathy: early magnetic resonance imaging findings and their evolution. Neuropediatrics 1995;26:183–91
    CrossRefPubMedWeb of Science
  12. ↵
    Rutherford M, Pennock J, Schwieso J, et al. Hypoxic-ischaemic encephalopathy: early and late magnetic resonance imaging findings in relation to outcome. Arch Dis Child Fetal Neonatal Ed 1996;75:F145–51
    Abstract/FREE Full Text
  13. ↵
    Rutherford MA, Pennock JM, Counsell SJ, et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics 1998;102:323–28
    Abstract/FREE Full Text
  14. ↵
    Barkovich AJ. Brain and spine injuries in infancy and childhood. In: Barkovich AJ, ed. Pediatric Neuroimaging, 4th ed. Philadelphia: Lippincott, Williams & Wilkins;2005 :190–290
  15. Sie LT, van der Knaap MS, Wezel-Meijler G, et al. Early MR features of hypoxic-ischemic brain injury in neonates with periventricular densities on sonograms. AJNR Am J Neuroradiol 2000;21:852–61
    Abstract/FREE Full Text
  16. ↵
    Christophe C, Clercx A, Blum D, et al. Early MR detection of cortical and subcortical hypoxic-ischemic encephalopathy in full-term-infants. Pediatr Radiol 1994;24:581–84
    CrossRefPubMed
  17. ↵
    Miller SP, Ramaswamy V, Michelson D, et al. Patterns of brain injury in term neonatal encephalopathy. J Pediatr 2005;146:453–60
    CrossRefPubMedWeb of Science
  18. ↵
    Rutherford MA. The asphyxiated term infant. In: Rutherford MA, ed. MRI of the Neonatal Brain. London, UK: WB Saunders;2002 :99–128
  19. ↵
    Holland BA, Haas DK, Norman D, et al. MRI of normal brain maturation. AJNR Am J Neuroradiol 1986;7:201–08
    Abstract/FREE Full Text
  20. Barkovich AJ, Kjos BO, Jackson DE Jr, et al. Normal maturation of the neonatal and infant brain: MR imaging at 1.5 T. Radiology 1988;166:173–80
    PubMedWeb of Science
  21. Martin E, Kikinis R, Zuerrer M, et al. Developmental stages of human brain: an MR study. J Comput Assist Tomogr 1988;12:917–22
    PubMedWeb of Science
  22. ↵
    Bird CR, Hedberg M, Drayer BP, et al. MR assessment of myelination in infants and children: usefulness of marker sites. AJNR Am J Neuroradiol 1989;10:731–40
    Abstract/FREE Full Text
  23. Dietrich RB. Magnetic resonance imaging of normal brain maturation. Semin Perinatol 1990;14:201–11
    PubMed
  24. Staudt M, Schropp C, Staudt F, et al. Myelination of the brain in MRI: a staging system. Pediatr Radiol 1993;23:169–76
    CrossRefPubMed
  25. Sie LT, van der Knaap MS, Wezel-Meijler G, et al. MRI assessment of myelination of motor and sensory pathways in the brain of preterm and term-born infants. Neuropediatrics 1997;28:97–105
    PubMedWeb of Science
  26. ↵
    Barkovich AJ. Normal development of the neonatal and infant brain, skull, and spine. In: Barkovich AJ, ed. Pediatric Neuroimaging, 4th ed. Philadelphia: Lippincott, Williams & Wilkins;2005 :17–75
  27. ↵
    Barkovich AJ, Westmark KD, Bedi HS, et al. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report. AJNR Am J Neuroradiol 2001;22:1786–94
    Abstract/FREE Full Text
  28. Cowan FM, Pennock JM, Hanrahan JD, et al. Early detection of cerebral infarction and hypoxic ischemic encephalopathy in neonates using diffusion-weighted magnetic resonance imaging. Neuropediatrics 1994;25:172–75
    PubMedWeb of Science
  29. Liu AY, Zimmerman RA, Haselgrove JC, et al. Diffusion-weighted imaging in the evaluation of watershed hypoxic-ischemic brain injury in pediatric patients. Neuroradiology 2001;43:918–26
    CrossRefPubMed
  30. Inder T, Huppi PS, Zientara GP, et al. Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques. J Pediatr 1999;134:631–34
    CrossRefPubMedWeb of Science
  31. Phillips MD, Zimmerman RA. Diffusion imaging in pediatric hypoxic ischemia injury. Neuroimaging Clin N Am 1999;9:41–52
    PubMed
  32. Rutherford M, Counsell S, Allsop J, et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics 2004;114:1004–14
    Abstract/FREE Full Text
  33. ↵
    Hanrahan JD, Sargentoni J, Azzopardi D, et al. Cerebral metabolism within 18 hours of birth asphyxia: a proton magnetic resonance spectroscopy study. Pediatr Res 1996;39:584–90
    PubMedWeb of Science
  34. Penrice J, Cady EB, Lorek A, et al. Proton magnetic resonance spectroscopy of the brain in normal preterm and term infants, and early changes after perinatal hypoxia-ischemia. Pediatr Res 1996;40:6–14
    PubMedWeb of Science
  35. Holshouser BA, Ashwal S, Luh GY, et al. Proton MR spectroscopy after acute central nervous system injury: outcome prediction in neonates, infants, and children. Radiology 1997;202:487–96
    PubMedWeb of Science
  36. Barkovich AJ, Baranski K, Vigneron D, et al. Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol 1999;20:1399–405
    Abstract/FREE Full Text
  37. ↵
    Maneru C, Junque C, Bargallo N, et al. (1)H-MR spectroscopy is sensitive to subtle effects of perinatal asphyxia. Neurology 2001;57:1115–18
    Abstract/FREE Full Text
  38. ↵
    Burdette JH, Ricci PE, Petitti N, et al. Cerebral infarction: time course of signal intensity changes on diffusion-weighted MR images. AJR Am J Roentgenol 1998;171:791–95
    PubMedWeb of Science
  39. ↵
    van der Knaap MS, Valk J. Myelination and retarded myelination. In: van der Knaap MS, Valk J, eds. Magnetic Resonance of Myelin, Myelination, and Myelin Disorders. Berlin, Germany: Springer-Verlag;1989 :26–29
  40. ↵
    Cowan FM. Magnetic resonance imaging of the normal infant brain: term to 2 years. In: Rutherford MA, ed. MRI of the Neonatal Brain. London, UK: WB Saunders;2002 :51–81
  41. ↵
    Sarnat HB, Sarnat MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol 1976;33:696–705
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 28 (4)
American Journal of Neuroradiology
Vol. 28, Issue 4
April 2007
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L. Liauw, I.H. Palm-Meinders, J. van der Grond, L.M. Leijser, S. le Cessie, L.A.E.M. Laan, B.C. Heeres, M.A. van Buchem, G. van Wezel-Meijler
Differentiating Normal Myelination from Hypoxic-Ischemic Encephalopathy on T1-Weighted MR Images: A New Approach
American Journal of Neuroradiology Apr 2007, 28 (4) 660-665;

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Differentiating Normal Myelination from Hypoxic-Ischemic Encephalopathy on T1-Weighted MR Images: A New Approach
L. Liauw, I.H. Palm-Meinders, J. van der Grond, L.M. Leijser, S. le Cessie, L.A.E.M. Laan, B.C. Heeres, M.A. van Buchem, G. van Wezel-Meijler
American Journal of Neuroradiology Apr 2007, 28 (4) 660-665;
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