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Research ArticleBrain

MR Imaging of Metronidazole-Induced Encephalopathy: Lesion Distribution and Diffusion-Weighted Imaging Findings

E. Kim, D.G. Na, E.Y. Kim, J.H. Kim, K.R. Son and K.H. Chang
American Journal of Neuroradiology October 2007, 28 (9) 1652-1658; DOI: https://doi.org/10.3174/ajnr.A0655
E. Kim
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D.G. Na
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E.Y. Kim
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J.H. Kim
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K.R. Son
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K.H. Chang
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References

  1. ↵
    Freeman CD, Klutman NE, Lamp KC. Metronidazole: a therapeutic review and update. Drugs 1997;54:679–708
    CrossRefPubMedWeb of Science
  2. ↵
    Frytak S, Moertel CH, Childs DS. Neurologic toxicity associated with high-dose metronidazole therapy. Ann Intern Med 1978;88:361–62
    CrossRefPubMedWeb of Science
  3. ↵
    Snavely SR, Hodges GR. The neurotoxicity of antibacterial agents. Ann Intern Med 1984;101:92–104
    CrossRefPubMedWeb of Science
  4. ↵
    Bradley WG, Karlsson IJ, Rassol CG. Metronidazole neuropathy. BMJ 1977;2:610–11
    FREE Full Text
  5. ↵
    Wright KH, Tyler JW. Recognizing metronidazole toxicosis in dogs. Vet Med 2003;98:410–18
  6. ↵
    Evans J, Levesque D, Knowles K, et al. Diazepam as a treatment for metronidazole toxicosis in dogs: a retrospective study of 21 cases. J Vet Intern Med 2003;17:304–10
    CrossRefPubMedWeb of Science
  7. ↵
    Ahmed A, Loes DJ, Bressler EL. Reversible resonance imaging findings in metronidazole-induced encephalopathy. Neurology 1995;45:588–89
    FREE Full Text
  8. Cecil KM, Halsted MJ, Schapiro M, et al. Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy. J Comput Assist Tomogr 2002;26:948–51
    CrossRefPubMedWeb of Science
  9. Horlen CK, Seifert CF, Malouf CS. Toxic metronidazole-induced MRI changes. Ann Pharmacother 2000;34:1273–75
    Abstract/FREE Full Text
  10. Woodruff BK, Wijdicks EF, Marshall WF. Reversible metronidazole-induced lesions of the cerebellar dentate nuclei. N Engl J Med 2002;346:68–69
    CrossRefPubMedWeb of Science
  11. ↵
    Heaney CJ, Campeau NG, Lindell EP. MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity. AJNR Am J Neuroradiol 2003;24:1615–17
    Abstract/FREE Full Text
  12. ↵
    Seok JI, Yi H, Song YM, et al. Metronidazole-induced encephalopathy and inferior olivary hypertrophy. Arch Neurol 2003;60:1796–800
    CrossRefPubMedWeb of Science
  13. Ito H, Maruyama M, Ogura N, et al. Reversible cerebellar lesions induced by metronidazole therapy for helicobacter pylori. J Neuroimaging 2004;14:369–71
    CrossRefPubMedWeb of Science
  14. ↵
    Kim DW, Park JM, Yoon BW, et al. Metronidazole-induced encephalopathy. J Neurol Sci 2004;224:107–11
    CrossRefPubMedWeb of Science
  15. Kim KH, Choi JW, Lee JY, et al. Two cases of metronidazole-induced encephalopathy. Korean J Gastroenterol 2005;45:195–200
    PubMed
  16. ↵
    De Bleecker JL, Leroy BP, Meire VI. Reversible visual deficit and corpus callosum lesions due to metronidazole toxicity. Eur Neurol 2005;53:93–95
    CrossRefPubMed
  17. ↵
    Karch FE, Lasagna L. Adverse drug reactions: a critical review. JAMA 1975;234:1236–41
    CrossRefPubMedWeb of Science
  18. ↵
    Duvernoy HM. Human Brain Stem Vessels. 2nd ed. Berlin, Germany: Springer-Verlag;1999 :60–81
  19. ↵
    von Rogulja P, Kovac W, Schmid H. Metronidazole encephalopathy in rats. Acta Neuropathol (Berl)1973;25:36–45
    CrossRefPubMed
  20. ↵
    Scharer K. Selective injury to Purkinje cells in the dog after oral administration of high-dose of nitroimidazole derivates [in German]. Verh Dtsch Ges Pathol 1972;56:407–10
    PubMed
  21. ↵
    Dow SW, LeCouteur RA, Poss ML, et al. Central nervous system toxicosis associated with metronidazole treatment of dogs: five cases (1984–1987). J Am Vet Med Assoc 1989;195:365–68
    PubMedWeb of Science
  22. ↵
    Olson EJ, Morales SC, McVey AS, et al. Putative metronidazole neurotoxicosis in a cat. Vet Pathol 2005;42:665–69
    CrossRefPubMed
  23. ↵
    Gallucci M, Bozzao A, Splendiani A, et al. Wernicke encephalopathy: MR findings in five patients. AJR Am J Roentgenol 1990;155:1309–14
    PubMedWeb of Science
  24. ↵
    Doss A, Mahad D, Romanowski CAJ. Wernicke encephalopathy: unusual findings in nonalcoholic patients. J Comput Assist Tomogr 2003;27:235–40
    CrossRefPubMed
  25. ↵
    Murata T, Fujito T, Kimura H, et al. Serial MRI and (1)H-MRS of Wernicke's encephalopathy: report of a case with remarkable cerebellar lesions on MRI. Psychiatry Res 2001;108:49–55
    CrossRefPubMed
  26. ↵
    Lapergue B, Klein I, Olivot JM, et al. Diffusion-weighted imaging of cerebellar lesions in Wernicke's encephalopathy. J Neuroradiol 2006;33:126–28
    PubMedWeb of Science
  27. ↵
    Bae SJ, Lee HK, Lee JH, et al. Wernicke's encephalopathy: atypical manifestation at MR imaging. AJNR Am J Neuroradiol 2001;22:1480–82
    Abstract/FREE Full Text
  28. ↵
    Kang SY, Kang JH, Choi JC, et al. Wernicke's encephalopathy: unusual manifestation on MRI. J Neurol 2005;252:1550–52
    CrossRefPubMed
  29. ↵
    Troncoso JC, Johnston MV, Hess KM, et al. Model of Wernicke's encephalopathy. Arch Neurol 1981;38:350–54
    CrossRefPubMedWeb of Science
  30. ↵
    Mulholland PJ. Susceptibility of the cerebellum to thiamine deficiency. Cerebellum 2006;5:55–63
    CrossRefPubMed
  31. ↵
    Geyer HL, Schaumburg HH, Herskovitz S. Methyl bromide intoxication causes reversible symmetric brainstem and cerebellar MRI lesions. Neurology 2005;64:1279–81
    Abstract/FREE Full Text
  32. ↵
    Jan W, Zimmerman RA, Wang ZJ, et al. MR diffusion imaging and MR spectroscopy of maple syrup urine disease during acute metabolic decompensation. Neuroradiology 2003;45:393–99
    CrossRefPubMedWeb of Science
  33. ↵
    Shen WC, Chiu HH, Chow KC, et al. MR imaging findings of enteroviral encephalomyelitis: an outbreak in Taiwan. AJNR Am J Neuroradiol 1999;20:1889–95
    Abstract/FREE Full Text
  34. ↵
    Cramer SC, Stegbauer KC, Schneider A, et al. Decreased diffusion in central pontine myelinolysis. AJNR Am J Neuroradiol 2001;22:1476–79
    Abstract/FREE Full Text
  35. ↵
    Uchino A, Takase Y, Nomiyama K, et al. Acquired lesions of the corpus callosum: MR imaging. Eur Radiol 2006;16:905–14
    CrossRefPubMedWeb of Science
  36. ↵
    Bulakbasi N, Kocaoglu M, Tayfun C, et al. Transient splenial lesion of the corpus callosum in clinically mild influenza-associated encephalitis/encephalopathy. AJNR Am J Neuroradiol 2006;27:1983–86
    Abstract/FREE Full Text
  37. Hagemann G, Mentzel HJ, Weisser H, et al. Multiple reversible MR signal changes caused by Epstein-Barr virus encephalitis. AJNR Am J Neuroradiol 2006;27:1447–49
    Abstract/FREE Full Text
  38. Kobata R, Tsukahara H, Nakai A, et al. Transient MR signal changes in the splenium of the corpus callosum in rotavirus encephalopathy: value of diffusion-weighted imaging. J Comput Assist Tomogr 2002;26:825–28
    CrossRefPubMedWeb of Science
  39. ↵
    Maeda M, Tsukahara H, Terada H, et al. Reversible splenial lesion with restricted diffusion in a wide spectrum of diseases and conditions. J Neuroradiol 2006;33:229–36
    PubMedWeb of Science
  40. ↵
    Sandoval C, Kutscher M, Jayabose S, et al. Neurotoxicity of intrathecal methotrexate: MR imaging findings. AJNR Am J Neuroradiol 2003;24:1887–90
    Abstract/FREE Full Text
  41. ↵
    Lucato LT, McKinney AM, Short J, et al. Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity. Australas Radiol 2006 :50:364–68
    CrossRefPubMed
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American Journal of Neuroradiology: 28 (9)
American Journal of Neuroradiology
Vol. 28, Issue 9
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E. Kim, D.G. Na, E.Y. Kim, J.H. Kim, K.R. Son, K.H. Chang
MR Imaging of Metronidazole-Induced Encephalopathy: Lesion Distribution and Diffusion-Weighted Imaging Findings
American Journal of Neuroradiology Oct 2007, 28 (9) 1652-1658; DOI: 10.3174/ajnr.A0655

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MR Imaging of Metronidazole-Induced Encephalopathy: Lesion Distribution and Diffusion-Weighted Imaging Findings
E. Kim, D.G. Na, E.Y. Kim, J.H. Kim, K.R. Son, K.H. Chang
American Journal of Neuroradiology Oct 2007, 28 (9) 1652-1658; DOI: 10.3174/ajnr.A0655
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