Single-Institution Experience with Matrix Coils in the Treatment of Intracranial Aneurysms: Comparison with Same-Center Outcomes with the Use of Platinum Coils

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Fig 1.
Aneurysm outcome grading scheme. A, Grade 1 “Obliterated” aneurysms had no contrast filling within the interstices of the coils or at the neck and were considered completely obliterated. B, Grade 2 “Neck Remnant” was used to classify cases with contrast filling at the base of the aneurysm within the neck or within an area subjacent to the main coil mass, but not at the actual neck. C, Grade 3 “Residual” or “Recurrent” was used if there was contrast filling within the interstices of the coil, or more contrast filling than simply at the neck, because of expansion of the aneurysm or compaction of the coil, depending on whether it was present immediately after the treatment (“Residual”) or at follow-up (“Recurrent”).

Table 1:

Baseline demographic characteristics (all procedures)

Characteristics	PGLA-Coated Coils	Bare Platinum Coils	P Value^*
Age (mean +/− SD) (yrs)	57 +/− 14	52 +/− 13	.04
SAH (%)	33	45	.11
Sex ratio (%) (M:F)	27:73	24:76	.70
Circulation (%) (Ant:Post)	79:21	60:40	.008
Average size (mm) (SD)	8.5 (6.1)	8.1 (5.4)	.63
Size category (mm) (%)			.50
0–10 mm	63 (77)	67 (84)
11–24 mm	17 (21)	11 (14)
>25 mm	2 (2)	2 (2)
>4 mm neck	24 (29)	19 (24)	.80
<4 mm neck	58 (71)	61 (76)	.80
Follow-up period (mos) mean (SD)	9.4 (5.2)	12.1 (7.0)	.009

Note:—SAH indicates subarachnoid hemorrhage; PGLA, polyglycolic/polylactic acid.
* ns = P > .05.

Table 2:

Aneurysm locations

Locations	PGLA-Coated Coils	Bare Platinum Coils
Anterior circulation total	65	47
Proximal ICA	10	6
Ophthalmic	8	15
SupHypo	7	5
PComA	14	6
AntChor	1	2
ICA terminus	7	2
AComA	16	9
ACA	0	2
MCA	2	0
Posterior circulation total	17	33
PICA	2	5
VBJ	1	1
SCA	2	4
TOB	12	22
PCA	0	1
Total	82	80

Note:—PGLA indicates polyglycolic/polylactic acid; proximal ICA, proximal internal carotid artery; Ophthalmic, ophthalmic artery; SupHypo, superior hypophyseal artery; PComA, posterior communicating artery; AntChor, anterior choroidal artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; PICA, posterior inferior cerebellar artery; VBJ, vertebrobasilar junction; SCA, superior cerebral artery; TOB, top of basilar artery; PCA, posterior cerebral artery.

Table 3:

Treatment characteristics

No. and Type of Aneurysms (%)	PGLA-Coated Coils (All)	100% PGLA-Coated Coils	Bare Platinum Coils
Stent-assisted	18/82 (22%)	8/42 (19%)	1/80 (1%)
Balloon remodeling	7/82 (9%)	1/42 (2%)	18/80 (23%)
Total treated with adjunctive device	25/82 (30%)	9/42 (21%)	19/80 (24%)
Intentional subtotal embolization to preserve parent vessel	2/82 (2%)	1/42 (2%)	4/80 (5%)

Table 4:

Treatment results

Note:—PGLA indicates polyglycolic/polylactic acid; OBL, obliterated; Resid + Recurr, residual and recurrence.

Table 5:

Retreatments

No. of Aneurysms (%)	PGLA-Coated Coils	100% PGLA-Coated Coils	Bare Platinum Coils
Overall	17/82 (21%)	8/42 (19%)	7/80 (9%)
Originally treated with Neuroform stent or balloon remodeling	4/17	1/8	1/7
Size (mm)
0–10	10/59 (17%)^*	6/34 (18%)	3/57 (5%)^*
11–24	6/20 (30%)^*	2/7 (29%)	2/19 (11%)^*
≥25	1/3 (33%)^*	0	2/4 (50%)^*
>4 Neck	4	1	1
<4 Neck	14	0	6

Table 6:

Initial and final results of treatment (no. of aneurysms/%) during follow-up interval

Table 7:

Evolution of final angiographic outcome based on initial results (no. of aneurysms)

	Matrix Coils		Bare Platinum Coils
OBL (23 aneurysms)		OBL (32 aneurysms)
OBL	14	OBL	19
Neck	1	Neck	2
Recurrence	3	Recurrence	0
No. retreated	2	No. retreated	0
Neck (30 aneurysms)		Neck (30 aneurysms)
OBL	10	OBL	7
Neck	4	Neck	5
Recurrence	9	Recurrence	9
No. retreated	6	No. retreated	6
Residual + Recurrence (29 aneurysms)		Residual + Recurrence (18 aneurysms)
OBL	5	OBL	2
Neck	4	Neck	1
Recurrence	18	Recurrence	8
No. retreated	9	No. retreated	1

Note:—OBL indicates obliterated.
Number of aneurysms with final result is less than initial number as a result of patients lost to follow-up.