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Research ArticleHead and Neck Imaging

Differentiation of Benign and Malignant Pathology in the Head and Neck Using 3T Apparent Diffusion Coefficient Values: Early Experience

A. Srinivasan, R. Dvorak, K. Perni, S. Rohrer and S.K. Mukherji
American Journal of Neuroradiology January 2008, 29 (1) 40-44; DOI: https://doi.org/10.3174/ajnr.A0743
A. Srinivasan
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R. Dvorak
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K. Perni
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S. Rohrer
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S.K. Mukherji
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    Fig 1.

    Scatter plot of ADC values in benign and malignant head and neck lesions at 3T strength.

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    Fig 2.

    A, T2-weighted axial image in a 35-year-old male patient with pathologically proved sinonasal undifferentiated carcinoma reveals a mass lesion in the left ethmoidal region (black arrows) with resultant sphenoidal mucocele (white arrows). B, The mass demonstrates heterogeneous enhancement (black arrows) on the post-gadolinium axial T1 image with no enhancement within the mucocele (white arrows). C, The ADC in the lesion averaged 1.042 × 10−3 mm2/s.

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    Fig 3.

    Axial T2-weighted (A) and postcontrast T1-weighted (B) images in a 22-year-old female patient demonstrate a T2 hyperintense lesion with intense contrast enhancement within the right masseter (black arrows), which was a biopsy-proven hemangioma. C, The ADC within the lesion measured 1.842 × 10−3 mm2/s.

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    Fig 4.

    Axial T2-weighted (A) and postcontrast T1-weighted (B) images in a 40-year-old female patient demonstrate a destructive left skull base pathology with heterogenous hyperintensity and cystic areas on T2-weighted images (black arrows) and nonenhancing portions on the postcontrast images (black arrows). This was a biopsy-proven adenosquamous cell carcinoma with an increased ADC value averaging 1.649 × 10−3 mm2/s, probably due to the necrotic areas within the tumor.

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    Fig 5.

    Axial MR images in a 29-year-old woman reveal a left jugular foramen mass that is hypointense on T2-weighted (A) images and enhances with contrast (B). This was a biopsy-proven meningioma with a decreased ADC value of 0.669 × 10−3 mm2/s, which may be due to hypercellularity within the benign tumor.

Tables

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    Table 1:

    3T ADC values in benign neck lesions

    Age, y/SexLesionADC, × 10−3 mm2/s
    89/FLipomatous hemangiopericytoma1.611 ± 0.167
    45/FFibrous dysplasia (F/U-15 y)*0.949 ± 0.070
    22/FMasseteric hemangioma1.842 ± 0.075
    57/FOrbital apex aspergillosis1.576 ± 0.214
    77/FClival mass stable for 7 y*1.915 ± 0.221
    37/MSchwannoma (vestibular)0.739 ± 0.079
    34/FSchwannoma (vestibular)1.566 ± 0.237
    36/FSchwannoma (vestibular)1.742 ± 0.181
    58/MSchwannoma (vestibular)1.922 ± 0.186
    66/MSchwannoma (jugular foramen)2.080 ± 0.332
    39/FSchwannoma (mandibular nerve)2.033 ± 0.521
    33/MOncocytoma (parotid)2.150 ± 0.004
    62/MMeningioma (cavernous sinus) (F/U of 2 y)*1.041 ± 0.158
    58/MMeningioma (cavernous sinus) (F/U of 3 y)*1.512 ± 0.462
    29/FMeningioma (jugular foramen)0.669 ± 0.128
    41/FGlomus jugulare1.379 ± 0.144
    31/FSarcoidosis (right cerebellopontine angle mass) (F/U 3 y)*0.863 ± 0.151
    • Note:—F/U indicates follow-up duration; ADC, apparent diffusion coefficient; F, female; M, male.

    • * No tissue confirmation was obtained.

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    Table 2:

    3T ADC values in malignant neck lesions

    Age, y/SexLesionStageADC, × 10−3 mm2/s
    65/MSinonasal undifferentiated SCC (P)T4N0M00.719 ± 0.157
    35/MSinonasal undifferentiated SCC (P)T4N0M01.042 ± 0.068
    51/FSCC Parotid (P)T4N2M11.064 ± 0.162
    61/MSCC palatine tonsil (P)T4N2BM00.847 ± 0.083
    62/MSCC palatine tonsil (P)T4N3M10.733 + 0.055
    62/MSCC palatine tonsil (MD)T3N1M01.261 ± 0.168
    59/MSCC base of tongue (P)T2N3M00.955 ± 0.095
    65/FSCC soft palate (P)T1N3M01.033 ± 0.183
    78/FSCC nasopharynx (W)T4N0M01.319 ± 0.194
    58/MSCC supraglottis (MD)T4N2BM01.278 + 0.070
    83/MSCC supraglottis (MD)T4N0M01.138 ± 0.148
    43/MSCC oropharynx (MD)T4N1M01.359 + 0.087
    90/FSCC orbit (W)T4N1M11.055 ± 0.047
    40/FAdenosquamous cell carcinoma skull baseT4N0M01.649 ± 0.229
    57/FCarcinoma ex pleomorphic adenoma (parotid)T2N1M01.241 ± 0.194
    69/MOrbital B-cell lymphoma3A0.438 ± 0.099
    • Note:—SCC indicates squamous cell carcinoma; W, well-differentiated; MD, moderately differentiated; P, poorly differentiated; F, female; M, male; ADC, apparent diffusion coefficient.

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American Journal of Neuroradiology: 29 (1)
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A. Srinivasan, R. Dvorak, K. Perni, S. Rohrer, S.K. Mukherji
Differentiation of Benign and Malignant Pathology in the Head and Neck Using 3T Apparent Diffusion Coefficient Values: Early Experience
American Journal of Neuroradiology Jan 2008, 29 (1) 40-44; DOI: 10.3174/ajnr.A0743

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Differentiation of Benign and Malignant Pathology in the Head and Neck Using 3T Apparent Diffusion Coefficient Values: Early Experience
A. Srinivasan, R. Dvorak, K. Perni, S. Rohrer, S.K. Mukherji
American Journal of Neuroradiology Jan 2008, 29 (1) 40-44; DOI: 10.3174/ajnr.A0743
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