OtherREVIEW ARTICLES
Noninvasive Molecular Neuroimaging Using Reporter Genes: Part II, Experimental, Current, and Future Applications
T.F. Massoud, A. Singh and S.S. Gambhir
American Journal of Neuroradiology March 2008, 29 (3) 409-418; DOI: https://doi.org/10.3174/ajnr.A0863
T.F. Massoud
A. Singh

References
- ↵Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 2003;17:545–80
- Weissleder R, Mahmood U. Molecular imaging. Radiology 2001;219:316–33
- Jaffer FA, Weissleder R. Molecular imaging in the clinical arena. JAMA 2005;16:855–62
- Gross S, Piwnica-Worms D. Molecular imaging strategies for drug discovery and development. Curr Opin Chem Biol 2006;10:334–42
- ↵Blasberg RG, Tjuvajev JG. Molecular-genetic imaging: current and future perspectives. J Clin Invest 2003;111:1620–29
- ↵Gambhir SS, Barrio JR, Herschman HR, et al. Assays for noninvasive imaging of reporter gene expression. Nucl Med Biol 1999;26:481–90
- ↵Blasberg R. Imaging gene expression and endogenous molecular processes: molecular imaging. J Cereb Blood Flow Metab 2002;22:1157–64
- ↵Massoud TF, Singh A, Gambhir SS. Noninvasive molecular neuroimaging using reporter genes. Part I, Principles revisited. AJNR Am J Neuroradiol 2008;29:229–34
- ↵Brenner M. Gene marking. Hum Gene Ther 1996;7:1927–36
- ↵Rehemtulla A, Stegman LD, Cardozo SJ, et al. Rapid and quantitative assessment of cancer treatment response using in vivo bioluminescence imaging. Neoplasia 2000;2:491–95
- ↵Deroose CM, Reumers V, Gijsbers R, et al. Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging. Mol Ther 2006;14:423–31. Epub 2006 Jul 3
- Burgos JS, Rosol M, Moats RA, et al. Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice. Biotechniques 2003;34:1184–88
- ↵Cho SY, Ravasi L, Szajek LP, et al. Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma. J Nucl Med 2005;46:1923–30
- Szentirmai O, Baker CH, Lin N, et al. Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect. Neurosurgery 2006;58:365–72
- Chaudhari AJ, Darvas F, Bading JR, et al. Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging. Phys Med Biol 2005;50:5421–41
- Yang M, Baranov E, Moossa AR, et al. Visualizing gene expression by whole-body fluorescence imaging. Proc Natl Acad Sci U S A 2000;97:12278–82
- Buursma AR, de Vries EF, Garssen J, et al. [18F]FHPG positron emission tomography for detection of herpes simplex virus (HSV) in experimental HSV encephalitis. J Virol 2005;79:7721–27
- Rubin JB, Kung AL, Klein RS, et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 2003;100:13513–18
- Moriyama EH, Bisland SK, Lilge L, et al. Bioluminescence imaging of the response of rat gliosarcoma to ALA-PpIX-mediated photodynamic therapy. Photochem Photobiol 2004;80:242–49
- ↵
- ↵
- ↵Chemaly ER, Yoneyama R, Frangioni JV, et al. Tracking stem cells in the cardiovascular system. Trends Cardiovasc Med 2005;15:297–302
- ↵
- Cook SH, Griffin DE. Luciferase imaging of a neurotropic viral infection in intact animals. J Virol 2003;77:5333–38
- ↵Luker GD, Bardill JP, Prior JL, et al. Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol 2002;76:12149–61
- ↵Franke-Fayard B, Janse CJ, Cunha-Rodrigues M, et al. Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration. Proc Natl Acad Sci U S A 2005;102:11468–73
- ↵Jenkins DE, Hornig YS, Oei Y, et al. Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice. Breast Cancer Res 2005;7:R444–54
- ↵Tang Y, Shah K, Messerli SM, et al. In vivo tracking of neural progenitor cell migration to glioblastomas. Hum Gene Ther 2003;14:1247–54
- ↵Shah K, Bureau E, Kim DE, et al. Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol 2005;57:34–41
- ↵Kim DE, Schellingerhout D, Ishii K, et al. Imaging of stem cell recruitment to ischemic infarcts in a murine model. Stroke 2004;35:952–57
- ↵
- ↵Okada S, Ishii K, Yamane J, et al. In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury. FASEB J 2005;19:1839–41. Epub 2005 Sep 1
- ↵Min JJ, Gambhir SS. Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects. Gene Ther 2004;11:115–25
- ↵Ray P, Bauer E, Iyer M, et al. Monitoring gene therapy with reporter gene imaging. Semin Nucl Med 2001;31:312–20
- ↵Lipshutz GS, Gruber CA, Cao Y. In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression. Mol Ther 2001;3:284–92
- ↵Yosmitsu M, Sato T, Tao K, et al. Bioluminescent imaging of a marking transgene and correction of Fabry mice by neonatal injection of recombinant lentiviral vectors. Proc Natl Acad Sci U S A 2004;101:16909–14
- ↵Ohlfest JR, Demorest ZL, Motooka Y, et al. Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Mol Ther 2005;12:778–88. Epub 2005 Sep 16
- ↵
- ↵Sharpless NE, DePinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 2006;5:741–54
- ↵Nieman BJ, Bock NA, Bishop J, et al. Magnetic resonance imaging for detection and analysis of mouse phenotypes. NMR Biomed 2005;18:447–68
- ↵Ciana P, Raviscioni M, Mussi P, et al. In vivo imaging of transcriptionally active estrogen receptors. Nat Med 2003;9:82–86
- Zhu L, Ramboz S, Hewitt D, et al. Non-invasive imaging of GFAP expression after neuronal damage in mice. Neurosci Lett 2004;367:210–12
- ↵Lin AH, Luo J, Mondshein LH, et al. Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol 2005;175:547–54
- Luo J, Lin AH, Masliah E, et al. Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration. Proc Natl Acad Sci U S A 2006;103:18326–31
- Zhang N, Ahsan MH, Purchio AF, et al. Serum amyloid A-luciferase transgenic mice: response to sepsis, acute arthritis, and contact hypersensitivity and the effects of proteasome inhibition. J Immunol 2005;174:8125–34
- Bonano VI, Oltean S, Brazas RM, et al. Imaging the alternative silencing of FGFR2 exon IIIb in vivo. RNA 2006;12:2073–79. Epub 2006 Oct 26
- ↵Kadurugamuwa JL, Modi K, Coquoz O, et al. Reduction of astrogliosis by early treatment of pneumococcal meningitis measured by simultaneous imaging, in vivo, of the pathogen and host response. Infect Immun 2005;73:7836–43
- Lemmen JG, Arends RJ, van Boxtel AL, et al. Tissue- and time-dependent estrogen receptor activation in estrogen reporter mice. J Mol Endocrinol 2004;32:689–701
- ↵Vooijs M, Jonkers J, Lyons S, et al. Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. Cancer Res 2002;62:1862–67
- ↵Momota H, Holland EC. Bioluminescence technology for imaging cell proliferation. Curr Opin Biotechnol 2005;16:681–86
- ↵Massoud TF, Paulmurugan R, De A, et al. Reporter gene imaging of protein-protein interactions in living subjects. Curr Opin Biotechnol 2007;18:31–37
- ↵Kim SB, Ozawa T, Watanabe S, et al. High-throughput sensing and noninvasive imaging of protein nuclear transport by using reconstitution of split Renilla luciferase. Proc Natl Acad Sci U S A 2004;101:11542–47. Epub 2004 Aug 2
- ↵
- ↵Somia N, Verma IM. Gene therapy: trials and tribulations. Nat Rev Genet 2000;1:91–99
- ↵
- ↵Swijnenburg RJ, van der Bogt KE, Sheikh AY, et al. Clinical hurdles for the transplantation of cardiomyocytes derived from human embryonic stem cells: role of molecular imaging. Curr Opin Biotecnol 2007;18:38–45
- ↵Yaghoubi S, Jensen MC, Wang Y, et al. Imaging of HSV1-tk expressing cytolytic T cell clones in glioma patients with [18F]FHBG positron emission tomography. Mol Ther 2007;15 (suppl 1):S229
- ↵Yaghoubi S, Barrio JR, Dahlbom M, et al. Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med 2001;42:1225–34
- ↵Yaghoubi SS, Couto MA, Chen CC, et al. Preclinical safety evaluation of 18F-FHBG: a PET reporter probe for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) or mutant HSV1-sr39tk's expression. J Nucl Med 2006;47:706–15
- ↵Abbott NJ, Chugani DC, Zaharchuk G, et al. Delivery of imaging agents into brain. Adv Drug Deliv Rev 1999;37:253–77
- ↵Abbott NJ, Ronnback L, Hansson E, et al. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006;7:41–53
- ↵Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol 2002;38:323–37
- ↵Kroll RA, Neuwelt EA. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 1998;42:1083–99
- ↵Iyer M, Barrio JR, Namavari M, et al. 8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET. J Nucl Med 2001;42:96–105
- ↵Hospers GAP, Calogero A, van Waarde A, et al. Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography. Cancer Res 2000;60:1488–91
- ↵Bidanset DJ, Placidi L, Rybak R, et al. Intravenous infusion of cereport increases uptake and efficacy of acyclovir in herpes simplex virus-infected rat brains. Antimicrob Agents Chemother 2001;45:2316–23
- ↵Wahl M, Unterberg A, Baethmann A, et al. Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema. J Cereb Blood Flow Metab 1988;8:621–34
- ↵LeMay DR, Kittaka M, Gordon EM, et al. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther 1998;9:989–95
- ↵Urbain JL. Reporter genes and imagine. J Nucl Med 2001;42:106–09
- ↵Jacobs A, Voges J, Reszka R, et al. Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas. Lancet 2001;358:727–29
- ↵Jacobs AH, Winkeler A, Dittmar C, et al. Prospects of molecular imaging in neurology. J Cell Biochem Suppl 2002;39:98–109
- ↵
- ↵Venisnik KM, Olafsen T, Gambhir SS, et al. Fusion of Gaussia luciferase to an engineered anti-carcinoembryonic antigen (CEA) antibody for in vivo optical imaging. Mol Imaging Biol 2007;9:267–77
- ↵Loening AM, Wu AM, Gambhir SS. Red-shifted Renilla reniformis luciferase variants for imaging in living subjects. Nat Methods 2007;4:641–43. Epub 2007 Jul 8
- ↵Duvvuri S, Majumdar S, Mitra AK. Drug delivery to the retina: challenges and opportunities. Expert Opin Biol Ther 2003;3:45–56
- ↵Majumdar S, Nashed YE, Patel K, et al. Dipeptide monoester ganciclovir prodrugs for treating HSV-1-induced corneal epithelial and stromal keratitis: in vitro and in vivo evaluations. J Ocul Pharmacol Ther 2005;21:463–74
- ↵
- ↵
- ↵Ray P, De A, Min JJ, et al. Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res 2004;64:1323–30
- ↵Massoud TF, Gambhir SS. Integrating noninvasive molecular imaging into molecular medicine: an evolving paradigm. Trends Mol Med 2007;13:183–91
In this issue
Advertisement
T.F. Massoud, A. Singh, S.S. Gambhir
Noninvasive Molecular Neuroimaging Using Reporter Genes: Part II, Experimental, Current, and Future Applications
American Journal of Neuroradiology Mar 2008, 29 (3) 409-418; DOI: 10.3174/ajnr.A0863
0 Responses
Jump to section
- Article
- Abstract
- Experimental Applications in Molecular Neuroimaging Using Reporter Genes
- Imaging Gene-Marked Cells
- Imaging of Gene Therapies
- Imaging of Transgenic Models of Spontaneous Disease
- Imaging of Molecular Interactions or Events
- Clinical Applications in Molecular Neuroimaging Using Reporter Genes
- Future Outlook
- References
- Figures & Data
- Info & Metrics
- Responses
- References
Related Articles
- No related articles found.
Cited By...
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Moritz F. Kircher, Sanjiv S. Gambhir, Jan GrimmNature Reviews Clinical Oncology 2011 8 11
- Chunxia Qin, Kai Cheng, Kai Chen, Xiang Hu, Yang Liu, Xiaoli Lan, Yongxue Zhang, Hongguang Liu, Yingding Xu, Lihong Bu, Xinhui Su, Xiaohua Zhu, Shuxian Meng, Zhen ChengScientific Reports 2013 3 1
- Lingling Zhao, Ken Abe, Shilpi Rajoria, Qi Pian, Margarida Barroso, Xavier IntesBiomedical Optics Express 2014 5 3
- A review of novel optical imaging strategies of the stroke pathology and stem cell therapy in strokeMarkus Aswendt, Joanna Adamczak, Annette TennstaedtFrontiers in Cellular Neuroscience 2014 8
- Sarah-Ann Aelvoet, Abdelilah Ibrahimi, Francesca Macchi, Rik Gijsbers, Chris Van den Haute, Zeger Debyser, Veerle BaekelandtThe Journal of Neuroscience 2014 34 49
- Rachel J. Sizemore, Sonja Seeger-Armbruster, Stephanie M. Hughes, Louise C. Parr-BrownlieJournal of Neurophysiology 2016 115 4
- Sarah-Ann Aelvoet, Jesus Pascual-Brazo, Sarah Libbrecht, Veerle Reumers, Rik Gijsbers, Chris Van den Haute, Veerle Baekelandt, Josef PrillerPLOS ONE 2015 10 11
- B Iordanova, W F Goins, D S Clawson, T K Hitchens, E T AhrensGene Therapy 2013 20 6
- Liang-Ting Lin, Shih-Hwa Chiou, Te-Wei Lee, Ren-Shyan Liu, Jeng-Jong Hwang, Chih-Hsien Chang, Hsin-I Ma, Yi-Jang LeeMolecular Imaging and Biology 2013 15 3
More in this TOC Section
Similar Articles
Advertisement