Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleBRAIN

Proton MR Spectroscopy in the Evaluation of Cerebral Metabolism in Patients with Fibromyalgia: Comparison with Healthy Controls and Correlation with Symptom Severity

M. Petrou, R.E. Harris, B.R. Foerster, S.A. Mclean, A. Sen, D.J. Clauw and P.C. Sundgren
American Journal of Neuroradiology May 2008, 29 (5) 913-918; DOI: https://doi.org/10.3174/ajnr.A0959
M. Petrou
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R.E. Harris
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.R. Foerster
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.A. Mclean
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A. Sen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.J. Clauw
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.C. Sundgren
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Wolfe F, Ross K, Anderson J, et al. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum 1995;38:19–28
    CrossRefPubMedWeb of Science
  2. ↵
    Lautenbacher S, Rollman GB, McCain GA. Multi-method assessment of experimental and clinical pain in patients with fibromyalgia. Pain 1994;59:45–53
    CrossRefPubMed
  3. Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 1997;70:41–51
    CrossRefPubMedWeb of Science
  4. ↵
    Petzke F, Clauw DJ, Ambrose K, et al. Increased pain sensitivity in fibromyalgia: effects of stimulus type and mode of presentation. Pain 2003;105:403–13
    CrossRefPubMedWeb of Science
  5. ↵
    Arroyo JF, Cohen ML. Abnormal responses to electrocutaneous stimulation in fibromyalgia. J Rheumatol 1993;20:1925–31
    PubMedWeb of Science
  6. ↵
    Lorenz J. Hyperalgesia or hypervigilance? An evoked potential approach to the study of fibromyalgia syndrome. Z Rheumatol 1998;57 Suppl 2:19–22
    CrossRefPubMedWeb of Science
  7. ↵
    Jones AK, Brown WD, Friston KJ, et al. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B Biol Sci 1991;244:39–44
    PubMed
  8. Derbyshire SW. Imaging the brain in pain. American Pain Society (APS) Bulletin 1999;9[3]:7–8
  9. ↵
    Aziz Q, Thompson DG, Ng VW, et al. Cortical processing of human somatic and visceral sensation. J Neuroscience 2000;20:2657–63
    Abstract/FREE Full Text
  10. ↵
    Mountz JM, Bradley LA, Modell JG, et al. Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis Rheum 1995;38:926–38
    PubMedWeb of Science
  11. ↵
    Kwiatek R, Barnden L, Tedman R, et al. Regional cerebral blood flow in fibromyalgia: single-photon-emission computed tomography evidence of reduction in the pontine tegmentum and thalami. Arthritis Rheum 2000;43:2823–33
    CrossRefPubMedWeb of Science
  12. ↵
    Gracely RH, Petzke F, Wolf JM, et al. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002;46:1333–43
    CrossRefPubMedWeb of Science
  13. ↵
    Cook DB, Lange G, Ciccone DS, et al. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol 2004;31:364–78
    Abstract/FREE Full Text
  14. ↵
    Giesecke T, Gracely RH, Grant MA, et al. Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum 2004;50:613–23
    CrossRefPubMedWeb of Science
  15. ↵
    Ross AJ, Sachdev PS. Magnetic resonance spectroscopy in cognitive research. Brain Res Brain Res Rev 2004;44:83–102
    CrossRefPubMedWeb of Science
  16. ↵
    Grachev ID, Fredrickson BE, Apkarian AV. Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. Pain 2000;89:7–18
    CrossRefPubMedWeb of Science
  17. ↵
    Wolfe F, Smythe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160–72
    CrossRefPubMedWeb of Science
  18. ↵
    Petzke F, Khine A, Williams D, et al. Dolorimetry performed at 3 paired tender points highly predicts overall tenderness. J Rheumatol 2001;28:2568–69
    FREE Full Text
  19. ↵
    Petzke F, Harris RE, Williams DA, et al. Differences in unpleasantness induced by experimental pressure between patients with fibromyalgia and controls. Eur J Pain 2005;9:325–35
    CrossRefPubMedWeb of Science
  20. ↵
    Gracely RH, Lota L, Walter DJ, et al. A multiple random staircase method of psychophysical pain assessment. Pain 1988;32:55–63
    CrossRefPubMedWeb of Science
  21. ↵
    Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1977;1:385–401
    Abstract
  22. ↵
    Spielberger CD, Gorsuch RC, Lushene RE, et al. Manual for the State-Trait Anxiety Inventory (Form Y): “Self-evaluation questionnaire.” Palo Alto, Calif: Consulting Psychologists;1983 :36
  23. ↵
    Rosenstiel AK, Keefe FJ. The use of coping strategies in chronic low back pain patients: relationship to patient characteristics and current adjustment. Pain 1983;17:33–44
    CrossRefPubMedWeb of Science
  24. ↵
    Petrou M, Sundgren PC, Pang Y, et al. Manually adjusted versus vendor preset definition of metabolite boundaries: impact on proton metabolite ratios. Acad Radiol 2007;14:340–43
    CrossRefPubMed
  25. ↵
    I. Olkin, ed. Contributions to Probability and Statistics: Essays in Honor of Harold Hotelling. Stanford, Calif: Stanford University Press;1960 :278–92
  26. ↵
    Giesecke T, Gracely RH, Williams DA, et al. The relationship between depression, clinical pain, and experimental pain in a chronic pain cohort. Arthritis Rheum 2005;52:1577–84
    CrossRefPubMedWeb of Science
  27. ↵
    Castillo M, Kwock L, Mukherji SK. Clinical applications of proton MR spectroscopy. AJNR Am J Neuroradiol 1998;17:1–15
  28. Maheshwari SR, Fatterpekar GM, Castillo M, et al. Proton MR spectroscopy of the brain. Semin Ultrasound CT MR 2000;21:434–51
    CrossRefPubMed
  29. ↵
    Burtscher IM, Holtas S. Proton MR spectroscopy in clinical routine. J Magn Reson Imaging 2001;13:560–67
    CrossRefPubMed
  30. ↵
    Bitsch A, Bruhn H, Vougioukas, V, et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 1999;20:1619–27
    Abstract/FREE Full Text
  31. ↵
    Tartaglia MC, Narayanan S, De Stefano N, et al. Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis. J Neurol 2002;249:1382–90
    CrossRefPubMedWeb of Science
  32. ↵
    Burtscher IM, Holtas S. Proton MR spectroscopy in brain tumors: clinical applications. Neuroradiology 2001;43:345–52
    CrossRefPubMedWeb of Science
  33. Bruhn H, Frahm J, Gungel MJ, et al. Noninvasive differentiation of tumors with the use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors. Radiology 1989;172:541–48
    PubMedWeb of Science
  34. Moller-Hartmann W, Herminghaus S, Krings T, et al. Clinical applications of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology 2002;44:371–81
    CrossRefPubMedWeb of Science
  35. Herminghaus S, Dierks T, Pilatus U, et al. Determination of histopathological tumor grade in neuroepithelial brain tumors by using spectral pattern analysis of in vivo spectroscopic data. J Neurosurg 2003;98:74–81
    PubMed
  36. ↵
    Weybright P, Sundgren PC, Maly P, et al. Differentiation between brain tumor recurrence and radiation injury using MR spectroscopy. AJR Am J Roentgenol 2005;185:1471–76
    CrossRefPubMedWeb of Science
  37. ↵
    Laubenberger J, Haussinger D, Bayer S, et al. HIV-related metabolic abnormalities in the brain: depiction with proton MR spectroscopy with short echo times. Radiology 1996;199:805–10
    PubMedWeb of Science
  38. Chang L, Ernst T. MR spectroscopy and diffusion-weighted MR imaging in focal brain lesions in AIDS. Neuroimaging Clin N Am 1997;7:409–26
    PubMed
  39. ↵
    Meyerhoff DJ, Bloomer C, Cardenas V, et al. Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV+ patients. Neurology 1999;52:995–1003
    Abstract/FREE Full Text
  40. ↵
    Brooks WM, Sabet A, Sibbitt WL Jr., et al. Neurochemistry of brain lesions determined by spectroscopic imaging in systemic lupus erythematosus. J Rheumatol 1997;24:2323–29
    PubMedWeb of Science
  41. Sibbit WL Jr, Haseler LJ, Griffey RR, et al. Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy. AJNR Am J Neuroradiol 1997;18:1271–77
    Abstract
  42. Lim MK, Suh CH, Kim HJ, et al. Systemic lupus erythematosus: brain magnetic resonance imaging and single voxel hydrogen1 MR spectroscopy. Radiology 2000;217:43–09
    PubMedWeb of Science
  43. Axford JS, Howe FA, Heron C, et al. Sensitivity of quantitative(1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus. Ann Rheum Dis 2001;60:106–11
    Abstract/FREE Full Text
  44. ↵
    Sundgren PC, Jennings J, Attwood JT, et al. MRI and 2D-CSI MR spectroscopy of the brain in the evaluation of patients with acute onset of neuropsychiatric systemic lupus erythematosus. Neuroradiology 2005;47:576–85
    CrossRefPubMedWeb of Science
  45. ↵
    Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Brain Res Rev 1996;22:229–44
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 29 (5)
American Journal of Neuroradiology
Vol. 29, Issue 5
May 2008
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Proton MR Spectroscopy in the Evaluation of Cerebral Metabolism in Patients with Fibromyalgia: Comparison with Healthy Controls and Correlation with Symptom Severity
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
M. Petrou, R.E. Harris, B.R. Foerster, S.A. Mclean, A. Sen, D.J. Clauw, P.C. Sundgren
Proton MR Spectroscopy in the Evaluation of Cerebral Metabolism in Patients with Fibromyalgia: Comparison with Healthy Controls and Correlation with Symptom Severity
American Journal of Neuroradiology May 2008, 29 (5) 913-918; DOI: 10.3174/ajnr.A0959

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Proton MR Spectroscopy in the Evaluation of Cerebral Metabolism in Patients with Fibromyalgia: Comparison with Healthy Controls and Correlation with Symptom Severity
M. Petrou, R.E. Harris, B.R. Foerster, S.A. Mclean, A. Sen, D.J. Clauw, P.C. Sundgren
American Journal of Neuroradiology May 2008, 29 (5) 913-918; DOI: 10.3174/ajnr.A0959
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging
  • Metabolic Abnormalities in Pain-Processing Regions of Patients with Fibromyalgia: A 3T MR Spectroscopy Study
  • Crossref (48)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Review of Cognitive Dysfunction in Fibromyalgia: A Convergence on Working Memory and Attentional Control Impairments
    Jennifer M. Glass
    Rheumatic Disease Clinics of North America 2009 35 2
  • Changes in Gray Matter Density in Fibromyalgia: Correlation With Dopamine Metabolism
    Patrick B. Wood, Michael F. Glabus, Ryan Simpson, James C. Patterson
    The Journal of Pain 2009 10 6
  • Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
    Nicolas Fayed, Javier Garcia-Campayo, Rosa Magallón, Helena Andrés-Bergareche, Juan V Luciano, Eva Andres, Julián Beltrán
    Arthritis Research & Therapy 2010 12 4
  • Brief Report: Excitatory and Inhibitory Brain Metabolites as Targets of Motor Cortex Transcranial Direct Current Stimulation Therapy and Predictors of Its Efficacy in Fibromyalgia
    Bradley R. Foerster, Thiago D. Nascimento, Misty DeBoer, Marycatherine A. Bender, Indie C. Rice, Dennis Q. Truong, Marom Bikson, Daniel J. Clauw, Jon‐Kar Zubieta, Richard E. Harris, Alexandre F. DaSilva
    Arthritis & Rheumatology 2015 67 2
  • Increased glutamate/glutamine compounds in the brains of patients with fibromyalgia: A magnetic resonance spectroscopy study
    Manuel Valdés, Antonio Collado, Nuria Bargalló, Mireia Vázquez, Lorena Rami, Emili Gómez, Manel Salamero
    Arthritis & Rheumatism 2010 62 6
  • What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of `centralized' pain?
    Vitaly Napadow, Richard E Harris
    Arthritis Research & Therapy 2014 16 4
  • Neuroimaging of fibromyalgia
    Richard H. Gracely, Kirsten R. Ambrose
    Best Practice & Research Clinical Rheumatology 2011 25 2
  • Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy
    Richard E. Harris, Daniel J. Clauw
    Neuroscience Letters 2012 520 2
  • Hippocampal Metabolite Abnormalities in Fibromyalgia: Correlation With Clinical Features
    Patrick B. Wood, Christina R. Ledbetter, Michael F. Glabus, Larry K. Broadwell, James C. Patterson
    The Journal of Pain 2009 10 1
  • Metabolic Abnormalities in Pain-Processing Regions of Patients with Fibromyalgia: A 3T MR Spectroscopy Study
    P. Feraco, A. Bacci, Fab. Pedrabissi, L. Passamonti, G. Zampogna, Fed. Pedrabissi, N. Malavolta, M. Leonardi
    American Journal of Neuroradiology 2011 32 9

More in this TOC Section

  • Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire