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Research ArticleINTERVENTIONAL

Simultaneous Treatment with Intravenous Recombinant Tissue Plasminogen Activator and Endovascular Therapy for Acute Ischemic Stroke Within 3 Hours of Onset

S. Sugiura, K. Iwaisako, S. Toyota and H. Takimoto
American Journal of Neuroradiology June 2008, 29 (6) 1061-1066; DOI: https://doi.org/10.3174/ajnr.A1012
S. Sugiura
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K. Iwaisako
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S. Toyota
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H. Takimoto
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References

  1. ↵
    Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med 1995;333:1581–87
    CrossRefPubMedWeb of Science
  2. ↵
    del Zoppo GJ, Poeck K, Pessin MS, et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 1992;32:78–86
    CrossRefPubMedWeb of Science
  3. ↵
    Wolpert SM, Bruckmann H, Greenlee R, et al. Neuroradiologic evaluation of patients with acute stroke treated with recombinant tissue plasminogen activator. The rt-PA Acute Stroke Study Group. AJNR Am J Neuroradiol 1993;14:3–13
    Abstract/FREE Full Text
  4. ↵
    Furlan A, Higashida R, Wechsler L, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA 1999;282:2003–11
    CrossRefPubMedWeb of Science
  5. ↵
    Lewandowski CA, Frankel M, Tomsick TA, et al. Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 1999;30:2598–605
    Abstract/FREE Full Text
  6. ↵
    Ernst R, Pancioli A, Tomsick T, et al. Combined intravenous and intra-arterial recombinant tissue plasminogen activator in acute ischemic stroke. Stroke 2000;31:2552–57
    Abstract/FREE Full Text
  7. Hill MD, Barber PA, Demchuk AM, et al. Acute intravenous–intra-arterial revascularization therapy for severe ischemic stroke. Stroke 2002;33:279–82
    Abstract/FREE Full Text
  8. Suarez JI, Zaidat OO, Sunshine JL, et al. Endovascular administration after intravenous infusion of thrombolytic agents for the treatment of patients with acute ischemic strokes. Neurosurgery 2002;50:251–59; discussion 259–60
    CrossRefPubMedWeb of Science
  9. ↵
    IMS Study Investigators. Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke 2004;35:904–11
    Abstract/FREE Full Text
  10. ↵
    Lee KY, Kim DI, Kim SH, et al. Sequential combination of intravenous recombinant tissue plasminogen activator and intra-arterial urokinase in acute ischemic stroke. AJNR Am J Neuroradiol 2004;25:1470–75
    Abstract/FREE Full Text
  11. ↵
    Zaidat OO, Suarez JI, Sunshine JL, et al. Thrombolytic therapy of acute ischemic stroke: correlation of angiographic recanalization with clinical outcome. AJNR Am J Neuroradiol 2005;26:880–84
    Abstract/FREE Full Text
  12. ↵
    Sekoranja L, Loulidi J, Yilmaz H, et al. Intravenous versus combined (intravenous and intra-arterial) thrombolysis in acute ischemic stroke: a transcranial color-coded duplex sonography–guided pilot study. Stroke 2006;37:1805–09
    Abstract/FREE Full Text
  13. Noser EA, Shaltoni HM, Hall CE, et al. Aggressive mechanical clot disruption: a safe adjunct to thrombolytic therapy in acute stroke? Stroke 2005;36:292–96
    Abstract/FREE Full Text
  14. ↵
    Smith WS. Safety of mechanical thrombectomy and intravenous tissue plasminogen activator in acute ischemic stroke. Results of the multi Mechanical Embolus Removal in Cerebral Ischemia (MERCI) trial, part I. AJNR Am J Neuroradiol 2006;27:1177–82
    Abstract/FREE Full Text
  15. ↵
    Yamaguchi T, Mori E, Minematsu K, et al. Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical trial (j-ACT). Stroke 2006;37:1810–15
    Abstract/FREE Full Text
  16. ↵
    Edaravone Acute Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003;15:222–29
    CrossRefPubMedWeb of Science
  17. ↵
    The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med 1985;312:932–36
    PubMed
  18. ↵
    Higashida RT, Furlan AJ, Roberts H, et al. Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke 2003;34:e109–37
    CrossRefPubMed
  19. ↵
    Sasaki O, Takeuchi S, Koike T, et al. Fibrinolytic therapy for acute embolic stroke: Intravenous, intracarotid, and intra-arterial local approaches. Neurosurgery 1995;36:246–52; discussion 252–43
    PubMedWeb of Science
  20. Labiche LA, Al-Senani F, Wojner AW, et al. Is the benefit of early recanalization sustained at 3 months? A prospective cohort study. Stroke 2003;34:695–98
    Abstract/FREE Full Text
  21. ↵
    Molina CA, Alexandrov AV, Demchuk AM, et al. Improving the predictive accuracy of recanalization on stroke outcome in patients treated with tissue plasminogen activator. Stroke 2004;35:151–56
    Abstract/FREE Full Text
  22. ↵
    Bourekas EC, Slivka AP, Shah R, et al. Intraarterial thrombolytic therapy within 3 hours of the onset of stroke. Neurosurgery 2004;54:39–44; discussion 44–36
    PubMedWeb of Science
  23. ↵
    The Interventional Management of Stroke (IMS) II study. Stroke 2007;38:2127–35
    Abstract/FREE Full Text
  24. ↵
    Rymer MM, Thurtchley D, Summers D, et al. Expanded modes of tissue plasminogen activator delivery in a comprehensive stroke center increases regional acute stroke interventions. Stroke 2003;34:e58–60
    CrossRefPubMed
  25. ↵
    Yoneyama T, Nakano S, Kawano H, et al. Combined direct percutaneous transluminal angioplasty and low-dose native tissue plasminogen activator therapy for acute embolic middle cerebral artery trunk occlusion. AJNR Am J Neuroradiol 2002;23:277–81
    Abstract/FREE Full Text
  26. ↵
    Alexandrov AV, Grotta JC. Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. Neurology 2002;59:862–67
    Abstract/FREE Full Text
  27. ↵
    Kidwell CS, Saver JL, Carneado J, et al. Predictors of hemorrhagic transformation in patients receiving intra-arterial thrombolysis. Stroke 2002;33:717–24
    Abstract/FREE Full Text
  28. ↵
    Hacke W, Albers G, Al-Rawi Y, et al. The desmoteplase in acute ischemic stroke trial (DIAS): A phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke 2005;36:66–73
    Abstract/FREE Full Text
  29. ↵
    Gupta R, Yonas H, Gebel J, et al. Reduced pretreatment ipsilateral middle cerebral artery cerebral blood flow is predictive of symptomatic hemorrhage post-intra-arterial thrombolysis in patients with middle cerebral artery occlusion. Stroke 2006;37:2526–30
    Abstract/FREE Full Text
  30. ↵
    Jones TH, Morawetz RB, Crowell RM, et al. Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 1981;54:773–82
    PubMedWeb of Science
  31. ↵
    Lees KR, Zivin JA, Ashwood T, et al. Nxy-059 for acute ischemic stroke. N Engl J Med 2006;354:588–600
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 29 (6)
American Journal of Neuroradiology
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June 2008
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Cite this article
S. Sugiura, K. Iwaisako, S. Toyota, H. Takimoto
Simultaneous Treatment with Intravenous Recombinant Tissue Plasminogen Activator and Endovascular Therapy for Acute Ischemic Stroke Within 3 Hours of Onset
American Journal of Neuroradiology Jun 2008, 29 (6) 1061-1066; DOI: 10.3174/ajnr.A1012

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Simultaneous Treatment with Intravenous Recombinant Tissue Plasminogen Activator and Endovascular Therapy for Acute Ischemic Stroke Within 3 Hours of Onset
S. Sugiura, K. Iwaisako, S. Toyota, H. Takimoto
American Journal of Neuroradiology Jun 2008, 29 (6) 1061-1066; DOI: 10.3174/ajnr.A1012
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  • Low-dose intravenous tissue plasminogen activator for acute ischaemic stroke: an alternative or a new standard?
  • Endovascular therapy yields significantly superior outcomes for large vessel occlusions compared with intravenous thrombolysis: is it time to randomize?
  • Safety of full-dose intravenous recombinant tissue plasminogen activator followed by multimodal endovascular therapy for acute ischemic stroke
  • Evaluation of an Intravenous-Endovascular Strategy in Patients with Acute Proximal Middle Cerebral Artery Occlusion
  • Bridging Therapy in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
  • The Effectiveness of Microballoon Angioplasty in Treating Middle Cerebral Artery Occlusion Beyond the Bifurcation
  • Stent Placement in Acute Cerebral Artery Occlusion
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

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  • Bridging Therapy in Acute Ischemic Stroke
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  • Intra-Arterial Thrombolysis vs. Standard Treatment or Intravenous Thrombolysis in Adults with Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
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    International Journal of Stroke 2015 10 1
  • Comparison of Partial (.6 mg/kg) versus Full-Dose (.9 mg/kg) Intravenous Recombinant Tissue Plasminogen Activator Followed by Endovascular Treatment for Acute Ischemic Stroke: A Meta-Analysis
    Alexandros L. Georgiadis, Muhammad Zeeshan Memon, Qaisar A. Shah, Gabriela Vazquez, M. Fareed K. Suri, Kamakshi Lakshminarayan, Adnan I. Qureshi
    Journal of Neuroimaging 2011 21 2
  • Endovascular therapy yields significantly superior outcomes for large vessel occlusions compared with intravenous thrombolysis: is it time to randomize?
    Ansaar T Rai, Jeffrey S Carpenter, Karthikram Raghuram, Thomas D Roberts, Daniel Rodgers, Gerald R Hobbs
    Journal of NeuroInterventional Surgery 2013 5 5
  • Combined Full-Dose IV and Endovascular Thrombolysis in Acute Ischaemic Stroke
    Rohit Bhatia, Nandavar Shobha, Bijoy K. Menon, Simerpreet P. Bal, Puneet Kochar, Vanessa Palumbo, John H. Wong, William F. Morrish, Mark E. Hudon, William Hu, Shelagh B. Coutts, Phillip A. Barber, Tim Watson, Mayank Goyal, Andrew M. Demchuk, Michael D. Hill
    International Journal of Stroke 2014 9 8
  • Training Guidelines for Intra-arterial Catheter-directed Treatment of Acute Ischemic Stroke: A Statement from a Special Writing Group of the Society of Interventional Radiology
    J.J. Connors, David Sacks, Carl M. Black, E. Bruce McIff, M.J.B. Stallmeyer, John W. Cole, Howard A. Rowley, Joan C. Wojak, Robert A. Mericle, Kieran J. Murphy, John F. Cardella
    Journal of Vascular and Interventional Radiology 2009 20 12
  • Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction
    Fan Sun, Heng Liu, Hui-xiao Fu, Shuo Zhang, Xu-dong Qian, Jia-jia Li, Yun-bo Zhu, Xiao-xuan Zhang, Jian Zhang, Hai-peng Qiu, Ling-ling Kang, Ya-jun Hu, Liang Zhao, Yan-juan Mi, Yan-jun Gao, Zhi-jie Dou, Zheng Ma
    Journal of International Medical Research 2020 48 5
  • Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion
    Xiao-Jun Wu, Feng Gao, Xu Liu, Qing Zhao
    Experimental and Therapeutic Medicine 2016 12 4
  • Endovascular Treatment Versus Intravenous Thrombolysis for Acute Ischemic Stroke: a Quantitative Review and Meta-Analysis of 21 Randomized Trials
    Chen-Chen Tan, Hui-Fu Wang, Jin-Long Ji, Meng-Shan Tan, Lan Tan, Jin-Tai Yu
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