Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

White Matter Changes Contribute to Corpus Callosum Atrophy in the Elderly: The LADIS Study

C. Ryberg, E. Rostrup, K. Sjöstrand, O.B. Paulson, F. Barkhof, P. Scheltens, E.C.W. van Straaten, F. Fazekas, R. Schmidt, T. Erkinjuntti, L.-O. Wahlund, A.M. Basile, L. Pantoni, D. Inzitari and G. Waldemar on behalf of the LADIS study group
American Journal of Neuroradiology September 2008, 29 (8) 1498-1504; DOI: https://doi.org/10.3174/ajnr.A1169
C. Ryberg
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E. Rostrup
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K. Sjöstrand
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
O.B. Paulson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Barkhof
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Scheltens
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E.C.W. van Straaten
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Fazekas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Schmidt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T. Erkinjuntti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.-O. Wahlund
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.M. Basile
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L. Pantoni
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Inzitari
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Waldemar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Hampel H, Teipel SJ, Alexander GE, et al. Corpus callosum atrophy is a possible indicator of region- and cell type-specific neuronal degeneration in Alzheimer disease: a magnetic resonance imaging analysis. Arch Neurol 1998;55:193–98
    CrossRefPubMedWeb of Science
  2. Moretti M, Carlucci G, Di CA, et al. Corpus callosum atrophy is associated with gait disorders in patients with leukoaraiosis. Neurol Sci 2005;26:61–66
    CrossRefPubMed
  3. Lyoo IK, Satlin A, Lee CK, et al. Regional atrophy of the corpus callosum in subjects with Alzheimer's disease and multi-infarct dementia. Psychiatry Res 1997;74:63–72
    CrossRefPubMedWeb of Science
  4. ↵
    Ryberg C, Rostrup E, Stegmann MB, et al. Clinical significance of corpus callosum atrophy in a mixed elderly population. Neurobiol Aging 2007;28:955–63
    CrossRefPubMedWeb of Science
  5. ↵
    Jokinen H, Ryberg C, Kalska H, et al. Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study. J Neurol Neurosurg Psychiatry 2007;78:491–96. Epub 2006 Oct 6
    Abstract/FREE Full Text
  6. ↵
    Pujol J, Vendrell P, Junque C, et al. When does human brain development end? Evidence of corpus callosum growth up to adulthood. Ann Neurol 1993;34:71–75
    CrossRefPubMedWeb of Science
  7. ↵
    Kertesz A, Polk M, Carr T. Cognition and white matter changes on magnetic resonance imaging in dementia. Arch Neurol 1990;47:387–91
    CrossRefPubMedWeb of Science
  8. Highley JR, Esiri MM, McDonald B, et al. The size and fibre composition of the corpus callosum with respect to gender and schizophrenia: a post-mortem study. Brain 1999;122 (pt 1):99–110
    Abstract/FREE Full Text
  9. Byne W, Bleier R, Houston L. Variations in human corpus callosum do not predict gender: a study using magnetic resonance imaging. Behav Neurosci 1988;102:222–27
    CrossRefPubMedWeb of Science
  10. Salat D, Ward A, Kaye JA, et al. Sex differences in the corpus callosum with aging. Neurobiol Aging 1997;18:191–97
    CrossRefPubMedWeb of Science
  11. Steinmetz H, Jancke L, Kleinschmidt A, et al. Sex but no hand difference in the isthmus of the corpus callosum. Neurology 1992;42:749–52
    Abstract/FREE Full Text
  12. O'Kusky J, Strauss E, Kosaka B, et al. The corpus callosum is larger with right-hemisphere cerebral speech dominance. Ann Neurol 1988;24:379–83
    CrossRefPubMedWeb of Science
  13. Kertesz A, Polk M, Howell J, et al. Cerebral dominance, sex, and callosal size in MRI. Neurology 1987;37:1385–88
    Abstract/FREE Full Text
  14. Nasrallah HA, Andreasen NC, Coffman JA, et al. A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biol Psychiatry 1986;21:274–82
    CrossRefPubMedWeb of Science
  15. ↵
    Witelson SF. The brain connection: the corpus callosum is larger in left-handers. Science 1985;229:665–68
    Abstract/FREE Full Text
  16. ↵
    Meguro K, Constans JM, Courtheoux P, et al. Atrophy of the corpus callosum correlates with white matter lesions in patients with cerebral ischaemia. Neuroradiology 2000;42:413–19
    CrossRefPubMedWeb of Science
  17. ↵
    van Swieten JC, van den Hout JH, van Ketel BA, et al. Periventricular lesions in the white matter on magnetic resonance imaging in the elderly: a morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain 1991;114 (pt 2):761–74
    Abstract/FREE Full Text
  18. ↵
    Witelson SF. Hand and sex differences in the isthmus and genu of the human corpus callosum: a postmortem morphological study. Brain 1989;112 (pt 3):799–835
    Abstract/FREE Full Text
  19. ↵
    Quint DJ. Multiple sclerosis and imaging of the corpus callosum. Radiology 1991;180:15–17
    PubMed
  20. ↵
    Yamauchi H, Fukuyama H, Ogawa M, et al. Callosal atrophy in patients with lacunar infarction and extensive leukoaraiosis: an indicator of cognitive impairment. Stroke 1994;25:1788–93
    Abstract/FREE Full Text
  21. ↵
    Vermersch P, Roche J, Hamon M, et al. White matter magnetic resonance imaging hyperintensity in Alzheimer's disease: correlations with corpus callosum atrophy. J Neurol 1996;243:231–34
    CrossRefPubMedWeb of Science
  22. ↵
    Teipel SJ, Hampel H, Alexander GE, et al. Dissociation between corpus callosum atrophy and white matter pathology in Alzheimer's disease. Neurology 1998;51:1381–85
    Abstract/FREE Full Text
  23. ↵
    Teipel SJ, Bayer W, Alexander GE, et al. Progression of corpus callosum atrophy in Alzheimer disease. Arch Neurol 2002;59:243–48
    CrossRefPubMedWeb of Science
  24. ↵
    Yamauchi H, Fukuyama H, Shio H. Corpus callosum atrophy in patients with leukoaraiosis may indicate global cognitive impairment. Stroke 2000;31:1515–20
    Abstract/FREE Full Text
  25. ↵
    Pantoni L, Basile AM, Pracucci G, et al. Impact of age-related cerebral white matter changes on the transition to disability: the LADIS study—rationale, design and methodology. Neuroepidemiology 2005;24:51–62
    CrossRefPubMedWeb of Science
  26. ↵
    Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 1969;9:179–86
    CrossRefPubMedWeb of Science
  27. ↵
    Fazekas F, Chawluk JB, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351–56
    CrossRefPubMedWeb of Science
  28. ↵
    Scheltens P, Barkhof F, Leys D, et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci 1993;114:7–12
    CrossRefPubMedWeb of Science
  29. ↵
    van Straaten EC, Fazekas F, Rostrup E, et al. Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study. Stroke 2006;37:836–40. Epub 2006 Jan 26
    Abstract/FREE Full Text
  30. ↵
    van Straaten EC, Scheltens P, Knol DL, et al. Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study. Stroke 2003;34:1907–12. Epub 2003 Jul 10
    Abstract/FREE Full Text
  31. ↵
    Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York: Thieme,1988
  32. ↵
    Cootes TF, Edwards GJ, Taylor CJ. Active appearance models. IEEE Trans Pattern Anal Mach Intell 2001;23:681–85
    CrossRef
  33. ↵
    Yamauchi H, Pagani M, Fukuyama H, et al. Progression of atrophy of the corpus callosum with deterioration of cerebral cortical oxygen metabolism after carotid artery occlusion: a follow up study with MRI and PET. J Neurol Neurosurg Psychiatry 1995;59:420–26
    Abstract/FREE Full Text
  34. ↵
    Pantel J, Schroder J, Essig M, et al. Corpus callosum in Alzheimer's disease and vascular dementia: a quantitative magnetic resonance study. J Neural Transm Suppl 1998;54:129–36
    PubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 29 (8)
American Journal of Neuroradiology
Vol. 29, Issue 8
September 2008
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
White Matter Changes Contribute to Corpus Callosum Atrophy in the Elderly: The LADIS Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
C. Ryberg, E. Rostrup, K. Sjöstrand, O.B. Paulson, F. Barkhof, P. Scheltens, E.C.W. van Straaten, F. Fazekas, R. Schmidt, T. Erkinjuntti, L.-O. Wahlund, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar
White Matter Changes Contribute to Corpus Callosum Atrophy in the Elderly: The LADIS Study
American Journal of Neuroradiology Sep 2008, 29 (8) 1498-1504; DOI: 10.3174/ajnr.A1169

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
White Matter Changes Contribute to Corpus Callosum Atrophy in the Elderly: The LADIS Study
C. Ryberg, E. Rostrup, K. Sjöstrand, O.B. Paulson, F. Barkhof, P. Scheltens, E.C.W. van Straaten, F. Fazekas, R. Schmidt, T. Erkinjuntti, L.-O. Wahlund, A.M. Basile, L. Pantoni, D. Inzitari, G. Waldemar
American Journal of Neuroradiology Sep 2008, 29 (8) 1498-1504; DOI: 10.3174/ajnr.A1169
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusion
    • Appendix: List of Participating Centers and Personnel
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Tractography at 3T MRI of Corpus Callosum Tracts Crossing White Matter Hyperintensities
  • Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke
  • Leukoaraiosis Predicts Cortical Infarct Volume After Distal Middle Cerebral Artery Occlusion
  • MRI characteristics and scoring in HDLS due to CSF1R gene mutations
  • Brain atrophy accelerates cognitive decline in cerebral small vessel disease: The LADIS study
  • Diffusion-Weighted Imaging and Cognition in the Leukoariosis and Disability in the Elderly Study
  • Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire