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Research ArticleBRAIN

MR Imaging of Familial Creutzfeldt-Jakob Disease: A Blinded and Controlled Study

R.K. Fulbright, C. Hoffmann, H. Lee, A. Pozamantir, J. Chapman and I. Prohovnik
American Journal of Neuroradiology October 2008, 29 (9) 1638-1643; DOI: https://doi.org/10.3174/ajnr.A1217
R.K. Fulbright
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C. Hoffmann
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H. Lee
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A. Pozamantir
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J. Chapman
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I. Prohovnik
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    Fig 1.

    Representative imaging findings on FLAIR, DWI, and ADC sequences in 3 different subjects with familial CJD. In A (fCJD 1), signal intensity abnormality involves the caudate nucleus, putamen, and thalamus, bilaterally. B (fCJD 2) demonstrates abnormal signal intensity primarily in the left caudate nucleus. In C (fCJD 3), there is involvement of both caudate nuclei, right greater than left, right cingulate gyrus, and right frontal lobe.

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    Fig 2.

    This subject (fCJD 4, case 2012) was rated as normal by FLAIR and DWI and was considered to be a false-negative by MR criteria (see Discussion). The ADC images (not shown) appeared normal.

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American Journal of Neuroradiology: 29 (9)
American Journal of Neuroradiology
Vol. 29, Issue 9
October 2008
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Cite this article
R.K. Fulbright, C. Hoffmann, H. Lee, A. Pozamantir, J. Chapman, I. Prohovnik
MR Imaging of Familial Creutzfeldt-Jakob Disease: A Blinded and Controlled Study
American Journal of Neuroradiology Oct 2008, 29 (9) 1638-1643; DOI: 10.3174/ajnr.A1217

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MR Imaging of Familial Creutzfeldt-Jakob Disease: A Blinded and Controlled Study
R.K. Fulbright, C. Hoffmann, H. Lee, A. Pozamantir, J. Chapman, I. Prohovnik
American Journal of Neuroradiology Oct 2008, 29 (9) 1638-1643; DOI: 10.3174/ajnr.A1217
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  • Enhanced Detection of Diffusion Reductions in Creutzfeldt-Jakob Disease at a Higher B Factor
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  • Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases
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