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Anomalous J-Modulation Effects on Amino Acids in Clinical 3T MR Spectroscopy

H.-S. Liu, H.-W. Chung, C.-J. Juan, S.-Y. Tsai, C.-Y. Wang, C.-C. Chan, G.-S. Huang, M.-C. Chou, C.-S. Lee, C.-W. Ko, N.-Y. Cho and C.-Y. Chen
American Journal of Neuroradiology October 2008, 29 (9) 1644-1648; DOI: https://doi.org/10.3174/ajnr.A1131
H.-S. Liu
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H.-W. Chung
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C.-J. Juan
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S.-Y. Tsai
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C.-Y. Wang
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C.-C. Chan
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G.-S. Huang
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M.-C. Chou
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C.-S. Lee
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C.-W. Ko
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N.-Y. Cho
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C.-Y. Chen
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    Fig 1.

    Transverse T2 fluid-attenuated inversion recovery MR image (A) and single-voxel spectra obtained in a 19-year-old male patient with brain abscess by using PRESS localization at 3T with TE = 40 ms (B) and TE = 144 ms (C). Succ indicates succinate; Ac, acetate; Ala, alanine; Lac, lactate; Lip, lipids; AA, amino acids.

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    Fig 2.

    Transverse postcontrast T1-weighted MR image (A) and single-voxel proton MR spectra obtained in a 42-year-old female patient with brain abscess by using PRESS localization at 3T with TE = 144 ms (B) and TE = 288 ms (C). Ala, indicates alanine; Lac, lactate; AA, amino acids.

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    Fig 3.

    Spectra from a phantom that contained 10 mmol/L of alanine to illustrate the anomalous J-modulation effect of the PRESS sequence at TE = 144 ms obtained from a 3T scanner, with the identical setting in the receiver gain at TE = 144 (A) and TE = 288 ms (B). Note at 1.47 ppm the incompletely inverted phase and reduced amplitude of the methyl doublet in the TE = 144 ms spectrum, evidence of the presence of an anomalous J-modulation effect.

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    Fig 4.

    Spectra from a phantom that contained only valine at TE = 40 ms (A) and TE = 144 ms (B). The complex doublets between 0.90 and 1.06 ppm show a clearly inverted phase at TE = 144 ms.

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American Journal of Neuroradiology: 29 (9)
American Journal of Neuroradiology
Vol. 29, Issue 9
October 2008
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H.-S. Liu, H.-W. Chung, C.-J. Juan, S.-Y. Tsai, C.-Y. Wang, C.-C. Chan, G.-S. Huang, M.-C. Chou, C.-S. Lee, C.-W. Ko, N.-Y. Cho, C.-Y. Chen
Anomalous J-Modulation Effects on Amino Acids in Clinical 3T MR Spectroscopy
American Journal of Neuroradiology Oct 2008, 29 (9) 1644-1648; DOI: 10.3174/ajnr.A1131

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Anomalous J-Modulation Effects on Amino Acids in Clinical 3T MR Spectroscopy
H.-S. Liu, H.-W. Chung, C.-J. Juan, S.-Y. Tsai, C.-Y. Wang, C.-C. Chan, G.-S. Huang, M.-C. Chou, C.-S. Lee, C.-W. Ko, N.-Y. Cho, C.-Y. Chen
American Journal of Neuroradiology Oct 2008, 29 (9) 1644-1648; DOI: 10.3174/ajnr.A1131
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  • Hepatic Alanine Differentiates Nonalcoholic Steatohepatitis From Simple Steatosis in Humans and Mice: A Proton MR Spectroscopy Study With Long Echo Time
    Tae‐Hoon Kim, Hong Young Jun, Ki‐Jong Kim, Young Hwan Lee, Myeung Su Lee, Keum Ha Choi, Ki Jung Yun, Yong Yeon Jeong, Chung Hwan Jun, Eun Young Cho, Kwon‐Ha Yoon
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  • Repeatability of Lac+ measurements in healthy human brain at 3 T
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