Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleBRAIN

Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide

H.A. Rowley, G. Scialfa, P.-y. Gao, J.A. Maldjian, D. Hassell, M.J. Kuhn, F.J. Wippold, M. Gallucci, B.C. Bowen, I.M. Schmalfuss, J. Ruscalleda, S. Bastianello and C. Colosimo
American Journal of Neuroradiology October 2008, 29 (9) 1684-1691; DOI: https://doi.org/10.3174/ajnr.A1185
H.A. Rowley
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Scialfa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.-y. Gao
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.A. Maldjian
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D. Hassell
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.J. Kuhn
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F.J. Wippold II
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Gallucci
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.C. Bowen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I.M. Schmalfuss
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Ruscalleda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Bastianello
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Colosimo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Albert FK, Forsting M, Sartor K, et al. Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 1994;34:45–60
    CrossRefPubMedWeb of Science
  2. ↵
    Kondziolka D, Patel A, Lunsford LD, et al. Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases. Int J Radiat Oncol Biol Phys 1999;45:427–34
    PubMedWeb of Science
  3. ↵
    Pintaske J, Martirosian P, Graf H, et al. Relaxivity of gadopentetate dimeglumine (Magnevist), gadobutrol (Gadovist), and gadobenate dimeglumine (MultiHance) in human blood plasma at 0.2, 1.5, and 3 Tesla. Invest Radiol 2006;41:213–21. Erratum in Invest Radiol 2006;41:859
    CrossRefPubMed
  4. ↵
    Rohrer M, Bauer H, Mintorovitch J, et al. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol 2005;40:715–24
    CrossRefPubMedWeb of Science
  5. ↵
    Cavagna FM, Maggioni F, Castelli PM, et al. Gadolinium chelates with weak binding to serum proteins: a new class of high-efficiency, general purpose contrast agents for magnetic resonance imaging. Invest Radiol 1997;32:780–96
    CrossRefPubMed
  6. ↵
    Giesel FL, von Tengg-Kobligk H, Wilkinson ID, et al. Influence of human serum albumin on longitudinal and transverse relaxation rates (R1 and R2) of magnetic resonance contrast agents. Invest Radiol 2006;41:222–28
    CrossRefPubMed
  7. ↵
    Knopp MV, Runge VM, Essig M, et al. Primary and secondary brain tumors at MR imaging: bicentric intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine. Radiology 2004;230:55–64
    PubMed
  8. ↵
    Maravilla KR, Maldjian JA, Schmalfuss IM, et al. Contrast enhancement of central nervous system lesions: multicenter intraindividual crossover comparative study of two MR contrast agents. Radiology 2006;240:389–400
    CrossRefPubMed
  9. ↵
    Kuhn MJ, Picozzi P, Maldjian JA, et al. Evaluation of intraaxial enhancing brain tumors on magnetic resonance imaging: intraindividual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine for visualization and assessment, and implications for surgical intervention. J Neurosurg 2007;106:557–66
    CrossRefPubMed
  10. ↵
    Colosimo C, Knopp MV, Barreau X, et al. A comparison of Gd-BOPTA and Gd-DOTA for contrast-enhanced MRI of intracranial tumours. Neuroradiology 2004;46:655–65. Epub 2004 Jun 15
    PubMed
  11. Colosimo C, Ruscalleda J, Korves M, et al. Detection of intracranial metastases: a multi-center, intra-patient comparison of gadobenate dimeglumine-enhanced MRI with routinely used contrast agents at equal dose. Invest Radiol 2001;36:72–81
    CrossRefPubMed
  12. ↵
    Essig M, Tartaro A, Tartaglione T, et al. Enhancing lesions of the brain: intra-individual crossover comparison of contrast enhancement after gadobenate dimeglumine versus established gadolinium comparators. Acad Radiol 2006;13:744–51
    CrossRefPubMed
  13. ↵
    Valk J, Algra PR, Hazenberg CJ, et al. A double-blind, comparative study of gadodiamide injection and gadopentetate dimeglumine in MRI of the central nervous system. Neuroradiology 1993;35:173–77
    CrossRefPubMed
  14. ↵
    Åkeson P, Jonsson E, Haugen I, et al. Contrast-enhanced MRI of the central nervous system: comparison between gadodiamide injection and gadolinium-DTPA. Neuroradiology 1995;37:229–33
    PubMed
  15. ↵
    Runge VM, Armstrong MR, Barr RG, et al. A clinical comparison of the safety and efficacy of MultiHance (gadobenate dimeglumine) and Omniscan (gadodiamide) in magnetic resonance imaging in patients with central nervous system pathology. Invest Radiol 2001;36:65–71
    CrossRefPubMed
  16. ↵
    Runge V, Parker JR, Donovan M, et al. Double-blind, efficacy evaluation of gadobenate dimeglumine, a gadolinium chelate with enhanced relaxivity, in malignant lesions of the brain. Invest Radiol 2002;37:269–80
    CrossRefPubMed
  17. ↵
    Yuh WT, Fisher DJ, Engelken JD, et al. MR evaluation of CNS tumors: dose comparison study with gadopentetate dimeglumine and gadoteridol. Radiology 1991;180:485–91
    PubMed
  18. ↵
    Schneider G, Kirchin MA, Pirovano G, et al. Gadobenate dimeglumine-enhanced magnetic resonance imaging of intracranial metastases: effect of dose on lesion detection and delineation. J Magn Reson Imaging 2001;14:525–39
    CrossRefPubMed
  19. ↵
    Knopp MV, Giesel FL, von Tengg-Kobligk H, et al. Contrast-enhanced MR angiography of the run-off vasculature: intraindividual comparison of gadobenate dimeglumine with gadopentetate dimeglumine. J Magn Reson Imaging 2003;17:694–702
    CrossRefPubMed
  20. Balci NC, Inan N, Anik Y, et al. Low-dose gadobenate dimeglumine versus standard-dose gadopentate dimeglumine for delayed contrast-enhanced cardiac magnetic resonance imaging. Acad Radiol. 2006;13:833–89
    CrossRefPubMedWeb of Science
  21. Pediconi F, Catalano C, Occhiato R, et al. Breast lesion detection and characterization at contrast-enhanced MR mammography: gadobenate dimeglumine versus gadopentetate dimeglumine. Radiology 2005;237:45–56
    PubMed
  22. ↵
    Schneider G, Maas R, Schultze Kool L, et al. Low-dose gadobenate dimeglumine versus standard dose gadopentetate dimeglumine for contrast-enhanced magnetic resonance imaging of the liver: an intra-individual crossover comparison. Invest Radiol 2003;38:85–94
    CrossRefPubMed
  23. ↵
    Warmuth-Metz M. Postoperative imaging after brain tumor resection. Acta Neurochir Suppl 2003;88:13–20
    PubMed
  24. ↵
    Ciric I, Vick NA, Mikhael MA, et al. Aggressive surgery for malignant supratentorial gliomas. Clin Neurosurg 1990;36:375–83
    PubMed
  25. ↵
    Ekinci G, Akpinar IN, Baltacioglu F, et al. Early-postoperative magnetic resonance imaging in glial tumors: prediction of tumor regrowth and recurrence. Eur J Radiol 2003;45:99–107
    CrossRefPubMed
  26. ↵
    Ewend MG, Elbabaa S, Carey LA. Current treatment paradigms for the management of patients with brain metastases. Neurosurgery 2005;57 (suppl 5):S66–77
    CrossRefPubMed
  27. ↵
    Kaal EC, Niel CG, Vecht CJ. Therapeutic management of brain metastasis. Lancet Neurol 2005;4:289–98
    CrossRefPubMedWeb of Science
  28. ↵
    Nimsky C, Ganslandt O, Fahlbusch R. 1.5 T: intraoperative imaging beyond standard anatomic imaging. Neurosurg Clin N Am 2005;16:185–200
    CrossRefPubMed
  29. ↵
    Oh DS, Black PM. A low-field intraoperative MRI system for glioma surgery: is it worthwhile? Neurosurg Clin N Am 2005;16:135–41
    CrossRefPubMed
  30. ↵
    Penfield JG, Reilly RF Jr. What nephrologists need to know about gadolinium. Nat Clin Pract Nephrol 2007;3:654–68
    PubMedWeb of Science
  31. Marckmann P, Skov L, Rossen K, et al. Case-control study of gadodiamide-related nephrogenic systemic fibrosis. Nephrol Dial Transplant 2007;22:3174–78
    Abstract/FREE Full Text
  32. ↵
    Bleicher AG, Kanal E. A serial dilution study of gadolinium-based MR imaging contrast agents. AJNR Am J Neuroradiol. 2008;29:668–73
    Abstract/FREE Full Text
  33. ↵
    Yrjänä SK, Vaara T, Karttunen A, et al. Pulse repetition time and contrast enhancement: simulation study of Gd-BOPTA and conventional contrast agent at different field strengths. Invest Radiol 2008;43:267–75
    PubMed
  34. ↵
    Runge VM, Biswas J, Wintersperger BJ, et al. The efficacy of gadobenate dimeglumine (Gd-BOPTA) at 3 Tesla in brain magnetic resonance imaging: comparison to 1.5 Tesla and a standard gadolinium chelate using a rat brain tumor model. Invest Radiol. 2006;41:244–48
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 29 (9)
American Journal of Neuroradiology
Vol. 29, Issue 9
October 2008
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
H.A. Rowley, G. Scialfa, P.-y. Gao, J.A. Maldjian, D. Hassell, M.J. Kuhn, F.J. Wippold, M. Gallucci, B.C. Bowen, I.M. Schmalfuss, J. Ruscalleda, S. Bastianello, C. Colosimo
Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide
American Journal of Neuroradiology Oct 2008, 29 (9) 1684-1691; DOI: 10.3174/ajnr.A1185

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Contrast-Enhanced MR Imaging of Brain Lesions: A Large-Scale Intraindividual Crossover Comparison of Gadobenate Dimeglumine versus Gadodiamide
H.A. Rowley, G. Scialfa, P.-y. Gao, J.A. Maldjian, D. Hassell, M.J. Kuhn, F.J. Wippold, M. Gallucci, B.C. Bowen, I.M. Schmalfuss, J. Ruscalleda, S. Bastianello, C. Colosimo
American Journal of Neuroradiology Oct 2008, 29 (9) 1684-1691; DOI: 10.3174/ajnr.A1185
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Reply:
  • The Benefits of High Relaxivity for Brain Tumor Imaging: Results of a Multicenter Intraindividual Crossover Comparison of Gadobenate Dimeglumine with Gadoterate Meglumine (The BENEFIT Study)
  • Gadolinium Contrast Agents for CNS Imaging: Current Concepts and Clinical Evidence
  • Multicenter, Intraindividual Comparison of Single-Dose Gadobenate Dimeglumine and Double-Dose Gadopentetate Dimeglumine for MR Angiography of the Supra-Aortic Arteries (the Supra-Aortic VALUE Study)
  • Does Higher Gadolinium Concentration Play a Role in the Morphologic Assessment of Brain Tumors? Results of a Multicenter Intraindividual Crossover Comparison of Gadobutrol versus Gadobenate Dimeglumine (the MERIT Study)
  • MR Imaging of Neoplastic Central Nervous System Lesions: Review and Recommendations for Current Practice
  • Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma
  • Diagnostic Yield of Double-Dose Gadobutrol in the Detection of Brain Metastasis: Intraindividual Comparison with Double-Dose Gadopentetate Dimeglumine
  • MR Imaging in Multiple Sclerosis: Review and Recommendations for Current Practice
  • Comparison of Gadobenate Dimeglumine and Gadodiamide in the Evaluation of Spinal Vascular Anatomy with MR Angiography
  • Comparative Studies of Different Gadolinium Agents in Brain Tumors: Differences between Gadolinium Chelates and Their Possible Influence on Imaging Features
  • Crossref (52)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The seed and soil hypothesis revisited—The role of tumor‐stroma interactions in metastasis to different organs
    Robert R. Langley, Isaiah J. Fidler
    International Journal of Cancer 2011 128 11
  • Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels
    Qingtang Lin, Krishnakumar Balasubramanian, Dominic Fan, Sun-Jin Kim, Lixia Guo, Hua Wang, Menashe Bar-Eli, Kenneth D. Aldape, Isaiah J. Fidler
    Neoplasia 2010 12 9
  • Gadolinium deposition and the potential for toxicological sequelae – A literature review of issues surrounding gadolinium‐based contrast agents
    Kerry A. Layne, Paul I. Dargan, John R. H. Archer, David M. Wood
    British Journal of Clinical Pharmacology 2018 84 11
  • Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma
    L.S. Hu, J.M. Eschbacher, A.C. Dueck, J.E. Heiserman, S. Liu, J.P. Karis, K.A. Smith, W.R. Shapiro, D.S. Pinnaduwage, S.W. Coons, P. Nakaji, J. Debbins, B.G. Feuerstein, L.C. Baxter
    American Journal of Neuroradiology 2012 33 1
  • MR Imaging in Multiple Sclerosis: Review and Recommendations for Current Practice
    K.-O. Lövblad, N. Anzalone, A. Dörfler, M. Essig, B. Hurwitz, L. Kappos, S.-K. Lee, M. Filippi
    American Journal of Neuroradiology 2010 31 6
  • MR Imaging of Neoplastic Central Nervous System Lesions: Review and Recommendations for Current Practice
    M. Essig, N. Anzalone, S.E. Combs, A. Dörfler, S.-K. Lee, P. Picozzi, À. Rovira, M. Weller, M. Law
    American Journal of Neuroradiology 2012 33 5
  • Gadolinium Contrast Agents for CNS Imaging: Current Concepts and Clinical Evidence
    E. Kanal, K. Maravilla, H.A. Rowley
    American Journal of Neuroradiology 2014 35 12
  • Solid Hypervascular Liver Lesions
    Giovanni Morana, Luigi Grazioli, Miles A. Kirchin, Maria Pia Bondioni, Niccolò Faccioli, Alessandro Guarise, Günther Schneider
    Investigative Radiology 2011 46 4
  • Time-delayed contrast-enhanced MRI improves detection of brain metastases and apparent treatment volumes
    Marina Kushnirsky, Vinh Nguyen, Joel S. Katz, Jared Steinklein, Lisa Rosen, Craig Warshall, Michael Schulder, Jonathan P. S. Knisely
    Journal of Neurosurgery 2016 124 2
  • Multicenter, Double-Blind, Randomized, Intraindividual Crossover Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine for Breast MR Imaging (DETECT Trial)
    Laura Martincich, Matthieu Faivre-Pierret, Christian M. Zechmann, Stefano Corcione, Harrie C. M. van den Bosch, Wei-Jun Peng, Antonella Petrillo, Katja C. Siegmann, Johannes T. Heverhagen, Pietro Panizza, Hans-Björn Gehl, Felix Diekmann, Federica Pediconi, Lin Ma, Fiona J. Gilbert, Francesco Sardanelli, Paolo Belli, Marco Salvatore, Karl-Friedrich Kreitner, Claudia M. Weiss, Chiara Zuiani
    Radiology 2011 258 2

More in this TOC Section

  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
  • Qualitative and Quantitative Analysis of MR Imaging Findings in Patients with Middle Cerebral Artery Stroke Implanted with Mesenchymal Stem Cells
  • Multimodal CT Provides Improved Performance for Lacunar Infarct Detection
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire