Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Case ReportBrain

Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings

R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans and P.M. Parizel
American Journal of Neuroradiology March 2010, 31 (3) 565-566; DOI: https://doi.org/10.3174/ajnr.A1889
R.A. Salgado
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.G. Jorens
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
I. Baar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Cras
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Hans
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.M. Parizel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Wolff K
    . Characterization of methadone overdose: clinical considerations and the scientific evidence. Ther Drug Monit 2002;24:457–70
    CrossRefPubMed
  2. 2.↵
    1. Chen CY,
    2. Lee KW,
    3. Lee CC,
    4. et al
    . Heroin-induced spongiform leukoencephalopathy: value of diffusion MR imaging. J Comput Assist Tomogr 2000;24:735–37
    CrossRefPubMed
  3. 3.↵
    1. Gacouin A,
    2. Lavoue S,
    3. Signouret T,
    4. et al
    . Reversible spongiform leucoencephalopathy after inhalation of heated heroin. Intensive Care Med 2003;29:1012–15. Epub 2003 Mar 14
    PubMedWeb of Science
  4. 4.↵
    1. Keogh CF,
    2. Andrews GT,
    3. Spacey SD,
    4. et al
    . Neuroimaging features of heroin inhalation toxicity: “chasing the dragon.” AJR Am J Roentgenol 2003;180:847–50
    PubMedWeb of Science
  5. 5.↵
    1. Kriegstein AR,
    2. Shungu DC,
    3. Millar WS,
    4. et al
    . Leukoencephalopathy and raised brain lactate from heroin vapor inhalation (“chasing the dragon”). Neurology 1999;53:1765–73
    Abstract/FREE Full Text
  6. 6.↵
    1. Offiah C,
    2. Hall E
    . Heroin-induced leukoencephalopathy: characterization using MRI, diffusion-weighted imaging, and MR spectroscopy. Clin Radiol 2008;63:146–52
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Chang WC,
    2. Lo CP,
    3. Kao HW,
    4. et al
    . MRI features of spongiform leukoencephalopathy following heroin inhalation. Neurology 2006;67:504
    FREE Full Text
  8. 8.↵
    1. Anselmo M,
    2. Campos Rainho A,
    3. do Carmo Vale M,
    4. et al
    . Methadone intoxication in a child: toxic encephalopathy? J Child Neurol 2006;21:618–20
    Abstract/FREE Full Text
  9. 9.↵
    1. Riascos R,
    2. Kumfa P,
    3. Rojas R,
    4. et al
    . Fatal methadone intoxication in a child. Emerg Radiol 2008;15:67–70
    CrossRefPubMed
  10. 10.↵
    1. Mills F,
    2. MacLennan SC,
    3. Devile CJ,
    4. et al
    . Severe cerebellitis following methadone poisoning. Pediatr Radiol 2008;38:227–29
    PubMed
  11. 11.↵
    1. Wolters EC,
    2. van Wijngaarden GK,
    3. Stam FC,
    4. et al
    . Leucoencephalopathy after inhaling “heroin” pyrolysate. Lancet 1982;2:1233–37
    PubMedWeb of Science
  12. 12.↵
    1. Nanan R,
    2. von Stockhausen HB,
    3. Petersen B,
    4. et al
    . Unusual pattern of leukoencephalopathy after morphine sulphate intoxication. Neuroradiology 2000;42:845–48
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Vella S,
    2. Kreis R,
    3. Lovblad KO,
    4. et al
    . Acute leukoencephalopathy after inhalation of a single dose of heroin. Neuropediatrics 2003;34:100–04
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans, P.M. Parizel
Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
American Journal of Neuroradiology Mar 2010, 31 (3) 565-566; DOI: 10.3174/ajnr.A1889

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Methadone-Induced Toxic Leukoencephalopathy: MR Imaging and MR Proton Spectroscopy Findings
R.A. Salgado, P.G. Jorens, I. Baar, P. Cras, G. Hans, P.M. Parizel
American Journal of Neuroradiology Mar 2010, 31 (3) 565-566; DOI: 10.3174/ajnr.A1889
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Case Report
    • Discussion
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Lesson of the month: Oxycodone-induced leukoencephalopathy: a rare diagnosis
  • Predicting the outcome of a comatose patient at the bedside
  • Delayed toxic-hypoxic encephalopathy
  • Crossref (45)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The histopathology of drugs of abuse
    Christopher Mark Milroy, Jacqueline Louise Parai
    Histopathology 2011 59 4
  • Losses and gains: chronic pain and altered brain morphology
    David Borsook, Nathalie Erpelding, Lino Becerra
    Expert Review of Neurotherapeutics 2013 13 11
  • Chronic oxycodone induces axonal degeneration in rat brain
    Ruping Fan, Lisa M. Schrott, Thomas Arnold, Stephen Snelling, Meghana Rao, Derrel Graham, Angela Cornelius, Nadejda L. Korneeva
    BMC Neuroscience 2018 19 1
  • Methadone-induced Damage to White Matter Integrity in Methadone Maintenance Patients: A Longitudinal Self-control DTI Study
    Wei Li, Qiang Li, Yarong Wang, Jia Zhu, Jianjun Ye, Xuejiao Yan, Yongbin Li, Jiajie Chen, Jierong Liu, Zhe Li, Wei Wang, Yijun Liu
    Scientific Reports 2016 6 1
  • Neurocognitive impairments and brain abnormalities resulting from opioid-related overdoses: A systematic review
    Erin L. Winstanley, James J. Mahoney, Felipe Castillo, Sandra D. Comer
    Drug and Alcohol Dependence 2021 226
  • White matter lesions in chronic migraine with medication overuse headache: a cross-sectional MRI study
    Zhenyang Zheng, Zijian Xiao, Xiaolei Shi, Minghui Ding, Wei Di, Weiwei Qi, Aiwu Zhang, Yannan Fang
    Journal of Neurology 2014 261 4
  • Methadone-Induced Toxic Leukoencephalopathy: Diagnosis and Follow-up by Magnetic Resonance Imaging Including Diffusion-Weighted Imaging and Apparent Diffusion Coefficient Maps
    Alfonso Cerase, Sara Leonini, Matteo Bellini, Giuseppe Chianese, Carlo Venturi
    Journal of Neuroimaging 2011 21 3
  • Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for the analysis of methadone and its metabolites in serum of heroin addicts
    Chun-Chi Wang, Cheng-Chung Chen, Shang-Jang Wang, Shou-Mei Wu
    Journal of Chromatography A 2011 1218 38
  • Acute brain injury following illicit drug abuse in adolescent and young adult patients: spectrum of neuroimaging findings
    Shai Shrot, Andrea Poretti, Elizabeth W Tucker, Bruno P Soares, Thierry AGM Huisman
    The Neuroradiology Journal 2017 30 2
  • Methadone use in a male with the FMRI premutation and FXTAS
    Zukhrofi Muzar, Reymundo Lozano, Andrea Schneider, Patrick E. Adams, Sultana M.H. Faradz, Flora Tassone, Randi J. Hagerman
    American Journal of Medical Genetics Part A 2015 167 6

More in this TOC Section

  • Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire