Functional Connectivity Targeting for Deep Brain Stimulation in Essential Tremor

Thalamic motor functional connectivity averaged from 58 subjects. The red cross identifies the anatomic coordinates of the voxel used for deep brain stimulation. Images are in radiologic format. Section locations are MNI: z = −2, 0, 2, 4 (top left to bottom right).

Single-subject thalamic motor functional connectivity. Voxels within the top 50% of peak z scores are shown in the thalamus. The red cross indicates the voxel that would be targeted by using anatomic positioning for thalamic deep brain stimulation. The left column shows mean connectivity scores from 50 five-minute scans obtained during 5 sessions with the subject in a resting state, and the right column, from 50 five-minute scans obtained during 5 different sessions with the subject watching cartoons. Images are in radiologic format.