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Research ArticleBrainE

Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease

J. Wang, H. You, J.-F. Liu, D.-F. Ni, Z.-X. Zhang and J. Guan
American Journal of Neuroradiology April 2011, 32 (4) 677-681; DOI: https://doi.org/10.3174/ajnr.A2350
J. Wang
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H. You
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J.-F. Liu
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D.-F. Ni
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Z.-X. Zhang
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J. Guan
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References

  1. 1.↵
    1. Ansari KA,
    2. Johnson A
    . Olfactory function in patients with Parkinson's disease. J Chronic Dis 1975;28:493–97
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Doty RL,
    2. Deems DA,
    3. Stellar S
    . Olfactory dysfunction in parkinsonism: a general deficit unrelated to neurologic signs, disease stage, or disease duration. Neurology 1988;38:1237–44
    Abstract/FREE Full Text
  3. 3.↵
    1. Mesholam RI,
    2. Moberg PJ,
    3. Mahr RN,
    4. et al
    . Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 1998;55:84–90
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Daum RF,
    2. Sekinger B,
    3. Kobal G,
    4. et al
    . Olfactory testing with “sniffin' sticks” for clinical diagnosis of Parkinson disease [in German]. Nervenarzt 2000;71:643–50
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Herting B,
    2. Schulze S,
    3. Reichmann H,
    4. et al
    . A longitudinal study of olfactory function in patients with idiopathic Parkinson's disease. J Neurol 2008;255:367–70
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Hawkes CH,
    2. Shephard BC,
    3. Daniel SE
    . Is Parkinson's disease a primary olfactory disorder? QJM 1999;92:473–80
    Abstract/FREE Full Text
  7. 7.↵
    1. Del Tredici K,
    2. Rub U,
    3. De Vos RA,
    4. et al
    . Where does Parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 2002;61:413–26
    PubMedWeb of Science
  8. 8.↵
    1. Ross GW,
    2. Abbott RD,
    3. Petrovitch H,
    4. et al
    . Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord 2006;21:2062–67
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Huisman E,
    2. Uylings HB,
    3. Hoogland PV
    . A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Mov Disord 2004;19:687–92
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Pearce RK,
    2. Hawkes CH,
    3. Daniel SE
    . The anterior olfactory nucleus in Parkinson's disease. Mov Disord 1995;10:283–87
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Silveira-Moriyama L,
    2. Holton JL,
    3. Kingsbury A,
    4. et al
    . Regional differences in the severity of Lewy body pathology across the olfactory cortex. Neurosci Lett 2009;453:77–80
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Braak H,
    2. Del Tredici K,
    3. Rub U,
    4. et al
    . Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003;24:197–211
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Wattendorf E,
    2. Welge-Lussen A,
    3. Fiedler K,
    4. et al
    . Olfactory impairment predicts brain atrophy in Parkinson's disease. J Neurosci 2009;29:15410–13
    Abstract/FREE Full Text
  14. 14.↵
    1. Hoogland PV,
    2. van den Berg R,
    3. Huisman E
    . Misrouted olfactory fibres and ectopic olfactory glomeruli in normal humans and in Parkinson and Alzheimer patients. Neuropathol Appl Neurobiol 2003;29:303–11
    CrossRefPubMed
  15. 15.↵
    1. Hummel T,
    2. Witt M,
    3. Reichmann H,
    4. et al
    . Immunohistochemical, volumetric, and functional neuroimaging studies in patients with idiopathic Parkinson's disease. J Neurol Sci 2010;289:119–22
    CrossRefPubMed
  16. 16.↵
    1. Kim JY,
    2. Lee WY,
    3. Chung EJ,
    4. et al
    . Analysis of olfactory function and the depth of olfactory sulcus in patients with Parkinson's disease. Mov Disord 2007;22:1563–66
    CrossRefPubMed
  17. 17.↵
    1. Held P,
    2. Seitz J,
    3. Frund R,
    4. et al
    . MRI detection of olfactory bulb and tract. J Neuroradiol 2000;27:112–18
    PubMed
  18. 18.↵
    1. Mueller A,
    2. Abolmaali ND,
    3. Hakimi AR,
    4. et al
    . Olfactory bulb volumes in patients with idiopathic Parkinson's disease: a pilot study. J Neural Transm 2005;112:1363–70
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Hawkes CH,
    2. Shephard BC,
    3. Daniel SE
    . Olfactory dysfunction in Parkinson's disease. J Neurol Neurosurg Psychiatry 1997;62:436–46
    Abstract/FREE Full Text
  20. 20.↵
    1. Gelb DJ,
    2. Oliver E,
    3. Gilman S
    . Diagnostic criteria for Parkinson disease. Arch Neurol 1999;56:33–39
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Zusho H,
    2. Asaka H,
    3. Okamoto M
    . Diagnosis of olfactory disturbance. Auris Nasus Larynx 1981;8:19–26
    PubMed
  22. 22.↵
    1. Hummel T,
    2. Damm M,
    3. Vent J,
    4. et al
    . Depth of olfactory sulcus and olfactory function. Brain Res 2003;975:85–89
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Abolmaali ND,
    2. Hietschold V,
    3. Vogl TJ,
    4. et al
    . MR evaluation in patients with isolated anosmia since birth or early childhood. AJNR Am J Neuroradiol 2002;23:157–64
    Abstract/FREE Full Text
  24. 24.↵
    1. Haehner A,
    2. Rodewald A,
    3. Gerber JC,
    4. et al
    . Correlation of olfactory function with changes in the volume of the human olfactory bulb. Arch Otolaryngol Head Neck Surg 2008;134:621–24
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Doty RL,
    2. McKeown DA,
    3. Lee WW,
    4. et al
    . A study of the test-retest reliability of ten olfactory tests. Chem Senses 1995;20:645–56
    Abstract/FREE Full Text
  26. 26.↵
    1. Kondo H,
    2. Matsuda T,
    3. Hashiba M,
    4. et al
    . A study of the relationship between the T&T olfactometer and the University of Pennsylvania Smell Identification Test in a Japanese population. Am J Rhinol 1998;12:353–58
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Rombaux P,
    2. Duprez T,
    3. Hummel T
    . Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology 2009;47:3–9
    PubMedWeb of Science
  28. 28.↵
    1. Haehner A,
    2. Hummel T,
    3. Reichmann H
    . Olfactory dysfunction as a diagnostic marker for Parkinson's disease. Expert Rev Neurother 2009;9:1773–79
    CrossRefPubMed
  29. 29.↵
    1. Braak H,
    2. Rub U,
    3. Gai WP,
    4. et al
    . Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 2003;110:517–36
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Lerner A,
    2. Bagic A
    . Olfactory pathogenesis of idiopathic Parkinson disease revisited. Mov Disord 2008;23:1076–84
    CrossRefPubMed
  31. 31.↵
    1. Braak H,
    2. Ghebremedhin E,
    3. Rub U,
    4. et al
    . Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 2004;318:121–34
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Hawkes CH,
    2. Del Tredici K,
    3. Braak H
    . Parkinson's disease: a dual-hit hypothesis. Neuropathol Appl Neurobiol 2007;33:599–614
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Doty RL,
    2. Shaman P,
    3. Dann M
    . Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984;32:489–502
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Scherfler C,
    2. Schocke MF,
    3. Seppi K,
    4. et al
    . Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease. Brain 2006;129:538–42
    Abstract/FREE Full Text
  35. 35.↵
    1. Zatorre RJ,
    2. Jones-Gotman M,
    3. Evans AC,
    4. et al
    . Functional localization and lateralization of human olfactory cortex. Nature 1992;360:339–40
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Sobel N,
    2. Khan RM,
    3. Saltman A,
    4. et al
    . The world smells different to each nostril. Nature 1999;402:35
    CrossRefPubMed
  37. 37.↵
    1. Buschhuter D,
    2. Smitka M,
    3. Puschmann S,
    4. et al
    . Correlation between olfactory bulb volume and olfactory function. Neuroimage 2008;42:498–502
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 32 (4)
American Journal of Neuroradiology
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J. Wang, H. You, J.-F. Liu, D.-F. Ni, Z.-X. Zhang, J. Guan
Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease
American Journal of Neuroradiology Apr 2011, 32 (4) 677-681; DOI: 10.3174/ajnr.A2350

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Association of Olfactory Bulb Volume and Olfactory Sulcus Depth with Olfactory Function in Patients with Parkinson Disease
J. Wang, H. You, J.-F. Liu, D.-F. Ni, Z.-X. Zhang, J. Guan
American Journal of Neuroradiology Apr 2011, 32 (4) 677-681; DOI: 10.3174/ajnr.A2350
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