Magnetization Transfer Imaging Demonstrates a Distributed Pattern of Microstructural Changes of the Cerebral Cortex in Amyotrophic Lateral Sclerosis

References

1. 1.↵
   1. Wijesekera LC,
   2. Leigh PN

   . Amyotrophic lateral sclerosis. Orphanet J Rare Dis 2009;4:1–22

   CrossRefPubMed
2. 2.↵
   1. Brooks BR,
   2. Miller RG,
   3. Swash M,
   4. et al

   . El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000;1:293–99

   CrossRefPubMedWeb of Science
3. 3.↵
   1. Charil A,
   2. Corbo M,
   3. Filippi M,
   4. et al

   . Structural and metabolic changes in the brain of patients with upper motor neuron disorders: a multiparametric MRI study. Amyotroph Lateral Scler 2009;26:1–11
4. 4.↵
   1. Abe K,
   2. Fujimura H,
   3. Kobayashi Y,
   4. et al

   . Degeneration of the pyramidal tracts in patients with amyotrophic lateral sclerosis: a premortem and postmortem magnetic resonance imaging study. J Neuroimaging 1997;7:208–12

   PubMedWeb of Science
5. 5.↵
   1. Ellis CM,
   2. Simmons A,
   3. Jones DK,
   4. et al

   . Diffusion tensor MRI assesses corticospinal tract damage in ASL. Neurology 1999;53:1051–58

   Abstract/FREE Full Text
6. 6.↵
   1. Cosottini M,
   2. Giannelli M,
   3. Siciliano G,
   4. et al

   . Diffusion-tensor MR imaging of corticospinal tract in amyotrophic lateral sclerosis and progressive muscular atrophy. Radiology 2005;237:258–64

   Abstract/FREE Full Text
7. 7.↵
   1. Kato Y,
   2. Matsumura K,
   3. Kinosada Y,
   4. et al

   . Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements. AJNR Am J Neuroradiol 1997;18:1541–47

   Abstract
8. 8.↵
   1. Da Rocha AJ,
   2. Oliveira ASB,
   3. Fonseca RB,
   4. et al

   . Detection of corticospinal tract compromise in amyotrophic lateral sclerosis with brain MR imaging: relevance of the T1-weighted spin-echo magnetization transfer contrast sequence. AJNR Am J Neuroradiol 2004;25:1509–15

   Abstract/FREE Full Text
9. 9.↵
   1. Maekawa S,
   2. Al-Sarraj S,
   3. Kibble M,
   4. et al

   . Cortical selective vulnerability in motor neuron disease: a morphometric study. Brain 2004;127 (pt 6):1237–51

   Abstract/FREE Full Text
10. 10.↵
    1. Grosskreutz J,
    2. Kaufmann J,
    3. Frädrich J,
    4. et al

    . Widespread sensorimotor and frontal cortical atrophy in amyotrophic lateral sclerosis. BMC Neurol 2006;6:17

    CrossRefPubMed
11. 11.↵
    1. Oba H,
    2. Araki T,
    3. Ohtomo K,
    4. et al

    . Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology 1993;189:843–46

    Abstract/FREE Full Text
12. 12.↵
    1. Ngai S,
    2. Tang YM,
    3. Du L,
    4. et al

    . Hyperintensity of the precentral gyral subcortical white matter and hypointensity of the precentral gyrus on fluid-attenuated inversion recovery: variation with age and implications for the diagnosis of amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2007;28:250–54

    Abstract/FREE Full Text
13. 13.↵
    1. Ashburner J,
    2. Friston KJ

    . Voxel-based morphometry: the methods. Neuroimage 2000;11:805–21

    CrossRefPubMedWeb of Science
14. 14.↵
    1. Agosta F,
    2. Pagani E,
    3. Rocca MA,
    4. et al

    . Voxel-based morphometry study of brain volumetry and diffusivity in amyotrophic lateral sclerosis patients with mild disability. Hum Brain Mapp 2007;28:1430–38

    CrossRefPubMedWeb of Science
15. 15.↵
    1. Mezzapesa DM,
    2. Ceccarelli A,
    3. Dicuonzo F,
    4. et al

    . Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2007;28:255–59

    Abstract/FREE Full Text
16. 16.↵
    1. Mitsumoto H,
    2. Ulug AM,
    3. Pullman SL,
    4. et al

    . Quantitative objective markers for upper and lower motor neuron dysfunction in ALS. Neurology 2007;68:1402–10

    Abstract/FREE Full Text
17. 17.↵
    1. Pioro EP,
    2. Antel JP,
    3. Cashman NR,
    4. et al

    . Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo. Neurology 1994;44:1933–38

    Abstract/FREE Full Text
18. 18.↵
    1. Wolff SD,
    2. Balaban RS

    . Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;10:135–44

    PubMedWeb of Science
19. 19.↵
    1. Ginestroni M,
    2. Battaglini M,
    3. Della Nave M,
    4. et al

    . Early structural changes in individuals at risk of familial Alzheimer's disease: a volumetry and magnetization transfer MR imaging study. J Neurol 2009;256:925–32

    CrossRefPubMed
20. 20.↵
    1. Ginestroni A,
    2. Battaglini M,
    3. Diciotti S,
    4. et al

    . Magnetization transfer MR imaging demonstrates degeneration of the subcortical and cortical gray matter in Huntington's disease. AJNR Am J Neuroradiol 2010;31:1807–12

    Abstract/FREE Full Text
21. 21.↵
    1. Birve A,
    2. Neuwirth C,
    3. Weber M,
    4. et al

    . A novel SOD1 splice site mutation associated with familial ALS revealed by SOD activity analysis. Hum Mol Genet 2010;1;19:4201–06.Epub 2010 Aug 13
22. 22.↵
    1. Cedarbaum JM,
    2. Stambler N,
    3. Malta E,
    4. et al

    . The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function—BDNF ALS Study Group (Phase III).J Neurol Sci 1999;169:13–21

    CrossRefPubMedWeb of Science
23. 23.↵
    1. Florence JM,
    2. Pandya S,
    3. King WM,
    4. et al

    . Intrarater reliability of manual muscle test (Medical Research Council scale) grades in Duchenne's muscular dystrophy. Phys Ther 1992;72:115–22

    Abstract/FREE Full Text
24. 24.↵
    1. Kollewe K,
    2. Mauss U,
    3. Krampfl K,
    4. et al

    . ALSFRS-R score and its ratio: a useful predictor for ALS-progression. J Neurol Sci 2008;275:69–73

    CrossRefPubMed
25. 25.↵
    1. Folstein MF,
    2. Folstein SE,
    3. McHugh PR

    . “Mini-mental state”: a practical method for grading the cognitive state of patients for clinician. J Psychiatr Res 1975;12:189–98

    CrossRefPubMedWeb of Science
26. 26.↵
    1. Zhang Y,
    2. Brady M,
    3. Smith S

    . Segmentation of brain MR images through a hidden Markov random field model and the expectation maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57

    CrossRefPubMedWeb of Science
27. 27.↵
    1. Smith SM,
    2. Zhang Y,
    3. Jenkinson M,
    4. et al

    . Accurate, robust and automated longitudinal and cross-sectional brain change analysis. Neuroimage 2002;17:479–89

    CrossRefPubMedWeb of Science
28. 28.↵
    1. Jenkinson M,
    2. Bannister PR,
    3. Brady JM,
    4. et al

    . Improved optimisation for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–41

    CrossRefPubMedWeb of Science
29. 29.↵
    1. Andersson JL,
    2. Jenkinson M,
    3. Smith S

    . Non-linear optimisation. FMRIB Analysis Group Technical Reports.TR07JA1. http://www.fmrib.ox.ac.uk/analysis/techrep. Accessed March 22, 2011
30. 30.↵
    1. Andersson JL,
    2. Jenkinson M,
    3. Smith S

    . Non-linear registration, aka spatial normalisation. FMRIB Analysis Group Technical Reports.TR07JA2. www.fmrib.ox.ac.uk/analysis/techrep. Accessed March 22, 2011
31. 31.↵
    1. De Stefano N,
    2. Battaglini M,
    3. Stromillo LM,
    4. et al

    . Brain damage as detected by magnetization transfer imaging is less pronounced in benign than in early relapsing multiple sclerosis. Brain 2006;129 (pt 8):2008–16.Epub 2006 Jun 30

    Abstract/FREE Full Text
32. 32.↵
    1. Gendron TF,
    2. Josephs KA,
    3. Petrucelli L

    . Review: transactive response DNA-binding protein 43 (TDP-43)—mechanisms of neurodegeneration. Neuropathol Appl Neurobiol 2010;36:97–112.Epub 2010 Feb 19

    PubMedWeb of Science
33. 33.↵
    1. Chang JL,
    2. Lomen-Hoerth C,
    3. Murphy J,
    4. et al

    . A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD. Neurology 2005;65:75–80

    Abstract/FREE Full Text
34. 34.↵
    1. Nihei K,
    2. McKee AC,
    3. Kowall NW

    . Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients. Acta Neuropathol 1993;86:55–64

    CrossRefPubMed
35. 35.↵
    1. Stanisz GJ,
    2. Kecojevic A,
    3. Bronskill MJ,
    4. et al

    . Characterizing white matter with magnetization transfer and T(2).Magn Reson Med 1999;42:1128–36

    CrossRefPubMedWeb of Science
36. 36.↵
    1. Schmierer K,
    2. Wheeler-Kingshott CA,
    3. Tozer DJ,
    4. et al

    . Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation. Magn Reson Med 2008;59:268–77

    CrossRefPubMedWeb of Science
37. 37.↵
    1. Schmierer K,
    2. Tozer DJ,
    3. Scaravilli F,
    4. et al

    . Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain. J Magn Reson Imaging 2007;26:41–51

    CrossRefPubMedWeb of Science
38. 38.↵
    1. Nakano I

    . Temporal lobe lesions in amyotrophic lateral sclerosis with or without dementia: a neuropathological study. Neuropathology 1993;13:215–27

    CrossRef
39. 39.↵
    1. Rizzolatti G,
    2. Luppino G

    . The cortical motor system. Neuron 2001;31:889–901

    CrossRefPubMedWeb of Science
40. 40.↵
    1. Kew JJ,
    2. Goldstein LH,
    3. Leigh PN,
    4. et al

    . The relationship between abnormalities of cognitive function and cerebral activation in amyotrophic lateral sclerosis: a neuropsychological and positron emission tomography study. Brain 1993;116:1399–423

    Abstract/FREE Full Text
41. 41.↵
    1. Turner MR,
    2. Cagnin A,
    3. Turkheimer FE,
    4. et al

    . Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study. Neurobiol Dis 2004;15:601–09

    CrossRefPubMedWeb of Science
42. 42.↵
    1. Abrahams S,
    2. Goldstein LH,
    3. Kew JJ,
    4. et al

    . Frontal lobe dysfunction in amyotrophic lateral sclerosis: a PET study. Brain 1996;119:2105–20

    Abstract/FREE Full Text
43. 43.↵
    1. Stanton BR,
    2. Williams VC,
    3. Leigh PN,
    4. et al

    . Altered cortical activation during a motor task in ALS: evidence for involvement of central pathways. J Neurol 2007;254:1260–67

    CrossRefPubMedWeb of Science
44. 44.↵
    1. Jackson M,
    2. Lennox G,
    3. Lowe J

    . Motor neurone disease-inclusion dementia. Neurodegeneration 1996;5:339–50

    CrossRefPubMedWeb of Science
45. 45.↵
    1. Abrahams S,
    2. Goldstein LH,
    3. Simmons A,
    4. et al

    . Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study. Brain 2004;127:1507–17

    Abstract/FREE Full Text
46. 46.↵
    1. Abrahams S,
    2. Leigh PN,
    3. Harvey A,
    4. et al

    . Verbal fluency and executive dysfunction in amyotrophic lateral sclerosis (ALS).Neuropsychologia 2000;38:734–47

    CrossRefPubMedWeb of Science
47. 47.↵
    1. Abrahams S,
    2. Leigh PN,
    3. Goldstein LH

    . Cognitive change in ALS: a prospective study. Neurology 2005;64:1222–26

    Abstract/FREE Full Text
48. 48.↵
    1. Kiernan JA,
    2. Hudson AJ

    . Frontal lobe atrophy in motor neuron diseases. Brain 1994;117:747–57

    Abstract/FREE Full Text
49. 49.↵
    1. Mackenzie IR,
    2. Feldman H

    . Neuronal intranuclear inclusions distinguish familial FTD-MND type from sporadic cases. Acta Neuropathol 2003;105:543–48

    PubMed
50. 50.↵
    1. Piao YS,
    2. Wakabayashi K,
    3. Kakita A,
    4. et al

    . Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000. Brain Pathol 2003;13:10–22

    PubMedWeb of Science