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Research ArticleBrain
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Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy

Z. Liu, D. Zheng, X. Wang, J. Zhang, S. Xie, J. Xiao and X. Jiang
American Journal of Neuroradiology May 2011, 32 (5) 898-902; DOI: https://doi.org/10.3174/ajnr.A2395
Z. Liu
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D. Zheng
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X. Wang
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J. Zhang
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S. Xie
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J. Xiao
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X. Jiang
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    Fig 1.

    A, A VOI is seen in the gray matter of the frontal lobe in a healthy subject. B, MR spectroscopy was performed with a set of b-values (b=45 s/mm2 and b=1050 s/mm2).

  • Fig 2.
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    Fig 2.

    A, A VOI is seen in the nonaffected frontal lobe in a patient with MELAS. B, MR spectroscopy was performed with a set of b-values (b=45 s/mm2 and b=1050 s/mm2).

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    Fig 3.

    A, A VOI is seen in the previously affected area of the patient with MELAS. B, MR spectroscopy was performed with a set of b-values (b=45 s/mm2 and b=1050 s/mm2).

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    Table 1:

    ADC values (mean) of metabolites in the gray matter of healthy subjects and in nonaffected areas of patients with MELAS

    Values (×10−3mm2/s)Healthy Subjects (n = 15)Nonaffected Areas in Patients (n = 8)PValue
    Cho0.20 ± 0.070.30 ± 0.08.00002
    Cr0.20 ± 0.070.30 ± 0.05.00002
    NAA0.21 ± 0.050.35 ± 0.06.00001
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    Table 2:

    ADCs (mean) of metabolites in the gray matter of healthy subjects and in lesions of patients with MELAS

    Values (×10−3mm2/s)Healthy Subject (n = 15)Lesions in Patients with MELAS (n = 10)PValue
    Cho0.20 ± 0.070.27 ± 0.07.0002
    Cr0.20 ± 0.070.31 ± 0.11.0002
    NAA0.21 ± 0.050.29 ± 0.06.0001
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American Journal of Neuroradiology: 32 (5)
American Journal of Neuroradiology
Vol. 32, Issue 5
1 May 2011
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Cite this article
Z. Liu, D. Zheng, X. Wang, J. Zhang, S. Xie, J. Xiao, X. Jiang
Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy
American Journal of Neuroradiology May 2011, 32 (5) 898-902; DOI: 10.3174/ajnr.A2395

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Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy
Z. Liu, D. Zheng, X. Wang, J. Zhang, S. Xie, J. Xiao, X. Jiang
American Journal of Neuroradiology May 2011, 32 (5) 898-902; DOI: 10.3174/ajnr.A2395
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