Article Figures & Data
Figures
- Fig 1.
GBM with peritumoral T2 prolongation of grade I. Postcontrast axial T1WI shows a heterogeneously enhancing lesion in the right parietal lobe with a maximal diameter of 4.5 cm (A). On the same section as A, axial T2WI demonstrates medium peritumoral T2 prolongation, which is smaller in area than the tumor (B). Two ROIs are placed in the prolonged region (black ring), with 2 mirror ROIs in the contralateral region (white ring). On the section inferior to B, another 2 ROIs are positioned in the hyperintense region and, accordingly, 2 mirror ROIs are placed in the contralateral region (C). For this measurement, the mean value of signal intensity is 852.5 for the prolonged region and 231.5 for the intact contralateral region. Thus, the nSI is 3.68 (852.5/231.5).
- Fig 2.
Solitary MET with peritumoral T2 prolongation of grade I. Postcontrast axial T1WI shows a heterogeneously enhancing lesion in the left frontal and anterior parietal lobes with a maximal diameter of 3.94 cm (A). On the same section as A, axial T2WI demonstrates medium peritumoral T2 prolongation, which is smaller in area than the tumor (B). On this section, 2 ROIs are placed in the prolonged region (black ring), with 2 mirror ROIs in the contralateral area (white ring). On the section superior to B, another 2 ROIs with 2 mirror ROIs are positioned in the prolongation region and the contralateral region, respectively (C). For this measurement, the mean value of signal intensity is 818.0 for the prolonged region and 280.5 for the intact contralateral region, respectively. Thus, the nSI is 2.92 (818.0/280.5).
- Fig 3.
GBM with peritumoral T2 prolongation of grade II. Postcontrast axial T1WI reveals a ringlike enhancing lesion in the left frontal lobe with a maximal diameter of 4.05 cm (A). On the same section as A, axial T2WI demonstrates obvious peritumoral hyperintensity, which is larger in area than the tumor (B). Two ROIs are placed in the prolonged region (black ring), with 2 mirror ROIs in the contralateral side (white ring). On the section inferior to B, 2 additional ROIs are positioned in the prolonged region and, accordingly, 2 mirror ROIs are placed in the contralateral side (C). The nSI is 4.18 (692.5/165.5).
- Fig 4.
Solitary MET with peritumoral T2 prolongation of grade II. Postcontrast axial T1WI shows a ringlike enhancing lesion in the right frontal lobe with a maximal diameter of 3.6 cm (A). On the same section as A, axial T2WI demonstrates strong peritumoral T2 prolongation, which is larger in area than the tumor (B). On this section, 2 ROIs and 2 mirror ROIs are placed in the prolonged region (black ring) and contralateral area (white ring). On the section superior to A, another 2 ROIs with 2 mirror ROIs are positioned in the prolonged region and the contralateral region, respectively (C). The nSI is 2.75 (603.5/219.5).
- Fig 5.
Box-and-whisker plots. Thick horizontal line = mean; whiskers = ± SD. The final nSI of peritumoral T2 in GBM is significantly higher than that of solitary MET in grade I (P = .014), grade II (P = .017), and tumors as a whole without grading (P < .001).
Tables
Tumor 1st Measurement 2nd Measurement Pearson Correlative Analysis GBM 3.1 ± 0.48 3.15 ± 0.5 P < .001, r = .894 MET 2.73 ± 0.3 2.74 ± 0.35 P < .001, r = .918 Total 2.98 ± 0.46 3.02 ± 0.45 P < .001, r = .912 Tumor Genesis Signa (n) Magnetom Trio (n) PValue GBM 3.16 ± 0.48 (19) 3.1 ± 0.49 (26) .676 MET 2.85 ± 0.35 (11) 2.61 ± 0.25 (10) .098 Total 3.05 ± 0.46 (30) 2.97 ± 0.48 (36) .484 - Table 3:
Sensitivity and specificity of final nSI of peritumoral T2 prolongation with high predictive power in differentiating GBM from solitary MET using ROC analysis
Peritumoral T2 Prolongation Grading Cutoff Value Sensitivity Specificity AUC Grade I 2.44 0.974 0.444 0.741 Grade II 3.085 0.857 0.917 0.869 Total 2.88 0.644 0.762 0.725
