Article Figures & Data
Figures
- Fig 1.
Example of CTP analysis results as presented by the 2 software packages. Top: software package A. On the left CBF, CBV, TTP, and MTT maps are displayed; on the right, the summary map is depicted: Red represents the infarct core area, and green represents the penumbra area. Bottom: perfusion analysis result of software package B. On the left, CBF, CBV, and TTP maps are displayed. The summary map is displayed on the right. In this summary map, red is used for infarct core area, and yellow, for penumbra area.
- Fig 2.
CTP analysis results of a 40-year-old woman with infarct in the left hemisphere. Both summary maps were generated from the same patient at the same height. The difference in the appearance of the gray image results from default settings in the visualization of the summary map of the 2 software analysis packages. Software A displays a section, and software B displays a time-maximum intensity projection image with the skull removed. The summary map from software package A (A) shows a smaller infarct core and larger penumbra compared with software package B (B). The total area of perfusion abnormality is similar.
- Fig 3.
Scatterplots and regression lines of the area of infarct core (A), penumbra (B), and perfusion abnormality (C) for the 2 software packages.
- Fig 4.
Bland-Altman plot including the limits of agreement between the 2 software packages in the infarct core (A), penumbra (B), and area of perfusion abnormality (C). For Bland-Altman plots, only the significant linear regression lines are shown. For the penumbra area, the slope is 1.62 (P < .001); for the area of perfusion abnormality, the slope is 0.43 (P < .001).
Tables
Statistical analysis of the area of infarct core, penumbra, and perfusion abnormality for 2 CTP analysis software packages
Average Difference ± SD (cm2) Relative Difference ± SD (%) Bland-Altman Limits of Agreement (cm2) Pearson Correlation Coefficient (P value) Slope of Regression Line (P value) Infarct core −23.6 ± 25.6 (P < .001) −114 ± 94 (P < .001) [−74.8, 27.6] 0.62 (<.001) 0.78 (<.001) Penumbra 15.8 ± 25.3 (P < .001) 31 ± 143 (P = .16) [−34.7, 66.3] 0.28 (.07) 1.28 (.07) Perfusion abnormality −7.81 ± 29.6 (P = .10) 56 ± 98 (P < .001) [−67.0, 51.4] 0.70 (<.001) 1.02 (<.001)
