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Research ArticleBrain
Open Access

Reduced Diffusion in a Subset of Acute MS Lesions: A Serial Multiparametric MRI Study

P. Eisele, K. Szabo, M. Griebe, C. Roßmanith, A. Förster, M. Hennerici and A. Gass
American Journal of Neuroradiology August 2012, 33 (7) 1369-1373; DOI: https://doi.org/10.3174/ajnr.A2975
P. Eisele
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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K. Szabo
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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M. Griebe
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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C. Roßmanith
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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A. Förster
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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M. Hennerici
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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A. Gass
aFrom the Department of Neurology, UniversitätsMedizin Mannheim, University of Heidelberg, Mannheim, Germany.
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References

  1. 1.↵
    1. Guttmann CR,
    2. Ahn SS,
    3. Hsu L,
    4. et al
    . The evolution of multiple sclerosis lesions on serial MR. AJNR Am J Neuroradiol 1995;16:1481–91
    Abstract
  2. 2.↵
    1. Kermode AG,
    2. Thompson AJ,
    3. Tofts P,
    4. et al
    . Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications. Brain 1990;113 (pt 5): 1477–89
    Abstract/FREE Full Text
  3. 3.↵
    1. Schaefer PW,
    2. Grant PE,
    3. Gonzalez RG
    . Diffusion-weighted MR imaging of the brain. Radiology 2000;217:331–45
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Horsfield MA,
    2. Larsson HB,
    3. Jones DK,
    4. et al
    . Diffusion magnetic resonance imaging in multiple sclerosis. J Neurol Neurosurg Psychiatry 1998;64 (suppl 1): S80–84
    PubMedWeb of Science
  5. 5.↵
    1. Castriota-Scanderbeg A,
    2. Sabatini U,
    3. Fasano F,
    4. et al
    . Diffusion of water in large demyelinating lesions: a follow-up study. Neuroradiology 2002;44:764–67
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Werring DJ,
    2. Brassat D,
    3. Droogan AG,
    4. et al
    . The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis: a serial diffusion MRI study. Brain 2000;123 (pt 8): 1667–76
    Abstract/FREE Full Text
  7. 7.↵
    1. Roychowdhury S,
    2. Maldjian JA,
    3. Grossman RI
    . Multiple sclerosis: comparison of trace apparent diffusion coefficients with MR enhancement pattern of lesions. AJNR Am J Neuroradiol 2000;21:869–74
    Abstract/FREE Full Text
  8. 8.↵
    1. Cercignani M,
    2. Iannucci G,
    3. Rocca MA,
    4. et al
    . Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI. Neurology 2000;54:1139–44
    Abstract/FREE Full Text
  9. 9.↵
    1. Fiebach JB,
    2. Jansen O,
    3. Schellinger PD,
    4. et al
    . Serial analysis of the apparent diffusion coefficient time course in human stroke. Neuroradiology 2002;44:294–98
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Schlaug G,
    2. Siewert B,
    3. Benfield A,
    4. et al
    . Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke. Neurology 1997;49:113–19
    Abstract/FREE Full Text
  11. 11.↵
    1. Tievsky AL,
    2. Ptak T,
    3. Farkas J
    . Investigation of apparent diffusion coefficient and diffusion tensor anisotropy in acute and chronic multiple sclerosis lesions. AJNR Am J Neuroradiol 1999;20:1491–99
    Abstract/FREE Full Text
  12. 12.↵
    1. Rosso C,
    2. Remy P,
    3. Creange A,
    4. et al
    . Diffusion-weighted MR imaging characteristics of an acute strokelike form of multiple sclerosis. AJNR Am J Neuroradiol 2006;27:1006–08
    Abstract/FREE Full Text
  13. 13.↵
    1. Przeklasa-Auth M,
    2. Ovbiagele B,
    3. Yim C,
    4. et al
    . Multiple sclerosis with initial stroke-like clinicoradiologic features: case report and literature review. J Child Neurol 2010;25:732–37
    Abstract/FREE Full Text
  14. 14.↵
    1. Balashov KE,
    2. Aung LL,
    3. Dhib-Jalbut S,
    4. et al
    . Acute multiple sclerosis lesion: conversion of restricted diffusion due to vasogenic edema. J Neuroimaging 2011;21:202–04
    CrossRefPubMed
  15. 15.↵
    1. Bugnicourt JM,
    2. Garcia PY,
    3. Monet P,
    4. et al
    . Teaching neuroimages: marked reduced apparent diffusion coefficient in acute multiple sclerosis lesion. Neurology 2010;74:e87
    FREE Full Text
  16. 16.↵
    1. Munoz Maniega S,
    2. Bastin ME,
    3. Armitage PA,
    4. et al
    . Temporal evolution of water diffusion parameters is different in grey and white matter in human ischaemic stroke. J Neurol Neurosurg Psychiatry 2004;75:1714–18
    Abstract/FREE Full Text
  17. 17.↵
    1. Gass A,
    2. Gaa J,
    3. Sommer A,
    4. et al
    . Echo-planar diffusion-weighted MRI in the diagnosis of acute ischemic stroke: characterisation of tissue abnormalities and limitations in the interpretation of imaging findings [in German]. Radiologe 1999;39:695–702
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Rocca MA,
    2. Cercignani M,
    3. Iannucci G,
    4. et al
    . Weekly diffusion-weighted imaging of normal-appearing white matter in MS. Neurology 2000;55:882–84
    Abstract/FREE Full Text
  19. 19.↵
    1. Rovira A,
    2. Pericot I,
    3. Alonso J,
    4. et al
    . Serial diffusion-weighted MR imaging and proton MR spectroscopy of acute large demyelinating brain lesions: case report. AJNR Am J Neuroradiol 2002;23:989–94
    Abstract/FREE Full Text
  20. 20.↵
    1. Szabo K,
    2. Poepel A,
    3. Pohlmann-Eden B,
    4. et al
    . Diffusion-weighted and perfusion MRI demonstrates parenchymal changes in complex partial status epilepticus. Brain 2005;128:1369–76
    Abstract/FREE Full Text
  21. 21.↵
    1. Lovblad KO,
    2. Baird AE,
    3. Schlaug G,
    4. et al
    . Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol 1997;42:164–70
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Warach S,
    2. Dashe JF,
    3. Edelman RR
    . Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging: a preliminary analysis. J Cereb Blood Flow Metab 1996;16:53–59
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Wieshmann UC,
    2. Symms MR,
    3. Shorvon SD
    . Diffusion changes in status epilepticus. Lancet 1997;350:493–94
    PubMedWeb of Science
  24. 24.↵
    1. McKinney AM,
    2. Kieffer SA,
    3. Paylor RT,
    4. et al
    . Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging. AJR Am J Roentgenol 2009;193:192–206
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Su KG,
    2. Banker G,
    3. Bourdette D,
    4. et al
    . Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis. Curr Neurol Neurosci Rep 2009;9:411–17
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Blamire AM,
    2. Anthony DC,
    3. Rajagopalan B,
    4. et al
    . Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study. J Neurosci 2000;20:8153–59
    Abstract/FREE Full Text
  27. 27.↵
    1. Lassmann H,
    2. Reindl M,
    3. Rauschka H,
    4. et al
    . A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions. Brain 2003;126:1347–57
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
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P. Eisele, K. Szabo, M. Griebe, C. Roßmanith, A. Förster, M. Hennerici, A. Gass
Reduced Diffusion in a Subset of Acute MS Lesions: A Serial Multiparametric MRI Study
American Journal of Neuroradiology Aug 2012, 33 (7) 1369-1373; DOI: 10.3174/ajnr.A2975

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Reduced Diffusion in a Subset of Acute MS Lesions: A Serial Multiparametric MRI Study
P. Eisele, K. Szabo, M. Griebe, C. Roßmanith, A. Förster, M. Hennerici, A. Gass
American Journal of Neuroradiology Aug 2012, 33 (7) 1369-1373; DOI: 10.3174/ajnr.A2975
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