4D Digital Subtraction Angiography: Implementation and Demonstration of Feasibility

Images show a selected projection from a 3D-DSA rotational acquisition (top left), a 4D-DSA timeframe (center), and a standard 3D-DSA reconstruction (right). The SNRs of the 3 images at the region indicated by the yellow arrows are shown beneath each image. The single image at the bottom shows traces of the profile across the 2 arteries indicated by the red line. These images were obtained by use of an IA injection of contrast medium.

Demonstration of the effects of reconstruction elements on accuracy of reconstructed simulated vessel signal curves. The digital phantom is shown in the top frame on the left. The vessels in the phantom (phantom artery and phantom vein) had specified time dependence. These are considered to represent ground truth. The input time curves for these vessels are shown in each panel for comparison. C indicates constraining image; P, projections. The reconstructed wave forms are shown: 1) after multiplication (represented by C × P) of the projections by a binary constraining image (top right); 2) multiplication of the projections by the binary constraining image plus an angular minimum search (represented by C × P + search, bottom left); and 3) multiplication of the projections by the binary constraining image followed by normalization by the estimate of the numbers of projected ray voxels obtained from the constraining image (C × P + Norm, bottom right). The y-axis shows arbitrary units of attenuation. The x-axis shows the projection number.

Four-dimensional DSA reconstruction from a 3D-DSA reconstruction performed for evaluation of an unruptured paraclinoid aneurysm. An IA injection of contrast was used for this examination. The top row shows selected timeframes viewed at the rate of 6 frames per second at a fixed viewing angle. The bottom row shows the same timeframes viewed at 4 different angles, which would have not been obtainable in a biplane acquisition because of the mechanical inability to position the A-plane gantry (red icon).

Comparison of intravenous 3D-DSA and early arterial phase time from a 4D-DSA reconstruction. In the standard 3D-DSA on the left, the overlap of both arteries and veins obscures visualization of the internal carotid arteries. In this example, there is no viewing angle that will eliminate this overlap in the 3D-DSA. The image on the right is an early arterial timeframe from a 4D-DSA reconstruction viewed from the same angle as the 3D-DSA on the left. In this 4D image, the full course the right internal carotid artery is clearly visualized (red arrows). The red ellipse shows the position of the distal segments of the internal carotid arteries in both images.

Color-coded 4D-DSA and bolus arrival images. The sequence was displayed at a rate of 6 frames per second for visualization of arrival times between 1 and 4.5 seconds. On the top of the figure, binarized 4D-DSA timeframes multiply a time-of-arrival map providing a dynamic display in which each pixel in each timeframe is represented by a quantitative time of arrival value. In the bottom half of the figure, a sliding Gaussian display window is used to show the passage of the bolus through the AVM. The 4D-DSA TOA volume (static) and 4D-DSA TOA (dynamic) 3D timeframes can be viewed from any angle. The 4D-DSA TOA (dynamic) 3D timeframes allow viewing of the temporal dynamics of the 4D-DSA TOA from any angle at any point in time for which data were acquired. These images were obtained by use of an IA injection of contrast medium.