MR Imaging Features of Amyloid-Related Imaging Abnormalities

J. Barakos; R. Sperling; S. Salloway; C. Jack; A. Gass; J.B. Fiebach; D. Tampieri; D. Melançon; Y. Miaux; G. Rippon; R. Black; Y. Lu; H.R. Brashear; H.M. Arrighi; K.A. Morris; M. Grundman

doi:10.3174/ajnr.A3500

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4. et al
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2.↵
1. Sperling R,
2. Bronen R,
3. Greenberg S,
4. et al
. Three cases of apparent vasogenic edema (VE) from a phase 2 clinical trial of the gamma secretase inhibitor BMS-708163 in patients with mild-to-moderate AD. Alzheimers Dement 2011;7(suppl):S377
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. Results from independent analyses of the EXPEDITION (solanezumab) study data conducted by the Alzheimer's Disease Cooperative Study (ADCS). In: Proceedings of the Annual Meeting of The American Neurological Association, Boston, Massachusetts. October 7–9, 2012
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CrossRef PubMed
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2. Sperling R,
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4. et al
. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009;73:2061–70
CrossRef
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1. Sperling RA,
2. Jack CR Jr.,
3. Black SE,
4. et al
. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement 2011;7:367–85
CrossRef PubMed Web of Science
7.↵
1. Sperling R,
2. Salloway S,
3. Brooks DJ,
4. et al
. Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol 2012;11:241–49
CrossRef PubMed
8.↵
1. Boche D,
2. Zotova E,
3. Weller RO,
4. et al
. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 2008;131(pt 12):3299–310
Abstract/FREE Full Text
9.↵
1. Eng JA,
2. Frosch MP,
3. Choi K,
4. et al
. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol 2004;55:250–56
CrossRef PubMed Web of Science
10.↵
1. Scolding NJ,
2. Joseph F,
3. Kirby PA,
4. et al
. Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy. Brain 2005;128(pt 3):500–15
Abstract/FREE Full Text
11.↵
1. Carlson C,
2. Estergard W,
3. Oh J,
4. et al
. Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab. Alzheimers Dement 2011;7:396–401
CrossRef PubMed Web of Science
12.↵
1. Oh U,
2. Gupta R,
3. Krakauer JW,
4. et al
. Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. Neurology 2004;62:494–97
CrossRef
13.↵
1. Kinnecom C,
2. Lev MH,
3. Wendell L,
4. et al
. Course of cerebral amyloid angiopathy-related inflammation. Neurology 2007;68:1411–16
CrossRef
14.↵
1. Savoiardo M,
2. Erbetta A,
3. Storchi G,
4. et al
. Case 159: cerebral amyloid angiopathy-related inflammation. Radiology 2010;256:323–27
CrossRef PubMed
15.↵
1. Sakaguchi H,
2. Ueda A,
3. Kosaka T,
4. et al
. Cerebral amyloid angiopathy-related inflammation presenting with steroid-responsive higher brain dysfunction: case report and review of the literature. J Neuroinflammation 2011;8:116
CrossRef PubMed
16.↵
1. Rinne JO,
2. Brooks DJ,
3. Rossor MN,
4. et al
. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010;9:363–72
CrossRef PubMed Web of Science
17.↵
1. Weller RO,
2. Subash M,
3. Preston SD,
4. et al
. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008;18:253–66
CrossRef PubMed Web of Science
18.↵
1. Schroeter S,
2. Khan K,
3. Barbour R,
4. et al
. Immunotherapy reduces vascular amyloid-beta in PDAPP mice. J Neurosci 2008;28:6787–93
Abstract/FREE Full Text
19.↵
1. Vinters HV
. Cerebral amyloid angiopathy: a critical review. Stroke 1987;18:311–24
FREE Full Text
20.↵
1. Filippi CG,
2. Ulug AM,
3. Lin D,
4. et al
. Hyperintense signal abnormality in subarachnoid spaces and basal cisterns on MR images of children anesthetized with propofol: new fluid-attenuated inversion recovery finding. AJNR Am J Neuroradiol. 2001;22:394–99
Abstract/FREE Full Text
21.↵
1. Stuckey SL,
2. Goh TD,
3. Heffernan T,
4. et al
. Hyperintensity in the subarachnoid space on FLAIR MRI. AJR Am J Roentgenol 2007;189:913–21
CrossRef PubMed

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More in this TOC Section

Show more Brain

[1] 1.↵
Black RS,
Sperling RA,
Safirstein B,
et al
. A single ascending dose study of bapineuzumab in patients with Alzheimer disease. Alzheimer Dis Assoc Disord 2010;24:198–203
CrossRef PubMed

[2] Black RS,

[3] Sperling RA,

[4] Safirstein B,

[5] et al

[6] 2.↵
Sperling R,
Bronen R,
Greenberg S,
et al
. Three cases of apparent vasogenic edema (VE) from a phase 2 clinical trial of the gamma secretase inhibitor BMS-708163 in patients with mild-to-moderate AD. Alzheimers Dement 2011;7(suppl):S377

[7] Sperling R,

[8] Bronen R,

[9] Greenberg S,

[10] et al

[11] 3.↵
Doody R
. Results from independent analyses of the EXPEDITION (solanezumab) study data conducted by the Alzheimer's Disease Cooperative Study (ADCS). In: Proceedings of the Annual Meeting of The American Neurological Association, Boston, Massachusetts. October 7–9, 2012

[12] Doody R

[13] 4.↵
Ostrowitzki S,
Deptula D,
Thurfjell L,
et al
. Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab. Arch Neurol 2012;69:198–207
CrossRef PubMed

[14] Ostrowitzki S,

[15] Deptula D,

[16] Thurfjell L,

[17] et al

[18] 5.↵
Salloway S,
Sperling R,
Gilman S,
et al
. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology 2009;73:2061–70
CrossRef

[19] Salloway S,

[20] Sperling R,

[21] Gilman S,

[22] et al

[23] 6.↵
Sperling RA,
Jack CR Jr.,
Black SE,
et al
. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement 2011;7:367–85
CrossRef PubMed Web of Science

[24] Sperling RA,

[25] Jack CR Jr.,

[26] Black SE,

[27] et al

[28] 7.↵
Sperling R,
Salloway S,
Brooks DJ,
et al
. Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. Lancet Neurol 2012;11:241–49
CrossRef PubMed

[29] Sperling R,

[30] Salloway S,

[31] Brooks DJ,

[32] et al

[33] 8.↵
Boche D,
Zotova E,
Weller RO,
et al
. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 2008;131(pt 12):3299–310
Abstract/FREE Full Text

[34] Boche D,

[35] Zotova E,

[36] Weller RO,

[37] et al

[38] 9.↵
Eng JA,
Frosch MP,
Choi K,
et al
. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol 2004;55:250–56
CrossRef PubMed Web of Science

[39] Eng JA,

[40] Frosch MP,

[41] Choi K,

[42] et al

[43] 10.↵
Scolding NJ,
Joseph F,
Kirby PA,
et al
. Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy. Brain 2005;128(pt 3):500–15
Abstract/FREE Full Text

[44] Scolding NJ,

[45] Joseph F,

[46] Kirby PA,

[47] et al

[48] 11.↵
Carlson C,
Estergard W,
Oh J,
et al
. Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab. Alzheimers Dement 2011;7:396–401
CrossRef PubMed Web of Science

[49] Carlson C,

[50] Estergard W,

[51] Oh J,

[52] et al

[53] 12.↵
Oh U,
Gupta R,
Krakauer JW,
et al
. Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. Neurology 2004;62:494–97
CrossRef

[54] Oh U,

[55] Gupta R,

[56] Krakauer JW,

[57] et al

[58] 13.↵
Kinnecom C,
Lev MH,
Wendell L,
et al
. Course of cerebral amyloid angiopathy-related inflammation. Neurology 2007;68:1411–16
CrossRef

[59] Kinnecom C,

[60] Lev MH,

[61] Wendell L,

[62] et al

[63] 14.↵
Savoiardo M,
Erbetta A,
Storchi G,
et al
. Case 159: cerebral amyloid angiopathy-related inflammation. Radiology 2010;256:323–27
CrossRef PubMed

[64] Savoiardo M,

[65] Erbetta A,

[66] Storchi G,

[67] et al

[68] 15.↵
Sakaguchi H,
Ueda A,
Kosaka T,
et al
. Cerebral amyloid angiopathy-related inflammation presenting with steroid-responsive higher brain dysfunction: case report and review of the literature. J Neuroinflammation 2011;8:116
CrossRef PubMed

[69] Sakaguchi H,

[70] Ueda A,

[71] Kosaka T,

[72] et al

[73] 16.↵
Rinne JO,
Brooks DJ,
Rossor MN,
et al
. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol 2010;9:363–72
CrossRef PubMed Web of Science

[74] Rinne JO,

[75] Brooks DJ,

[76] Rossor MN,

[77] et al

[78] 17.↵
Weller RO,
Subash M,
Preston SD,
et al
. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol 2008;18:253–66
CrossRef PubMed Web of Science

[79] Weller RO,

[80] Subash M,

[81] Preston SD,

[82] et al

[83] 18.↵
Schroeter S,
Khan K,
Barbour R,
et al
. Immunotherapy reduces vascular amyloid-beta in PDAPP mice. J Neurosci 2008;28:6787–93
Abstract/FREE Full Text

[84] Schroeter S,

[85] Khan K,

[86] Barbour R,

[87] et al

[88] 19.↵
Vinters HV
. Cerebral amyloid angiopathy: a critical review. Stroke 1987;18:311–24
FREE Full Text

[89] Vinters HV

[90] 20.↵
Filippi CG,
Ulug AM,
Lin D,
et al
. Hyperintense signal abnormality in subarachnoid spaces and basal cisterns on MR images of children anesthetized with propofol: new fluid-attenuated inversion recovery finding. AJNR Am J Neuroradiol. 2001;22:394–99
Abstract/FREE Full Text

[91] Filippi CG,

[92] Ulug AM,

[93] Lin D,

[94] et al

[95] 21.↵
Stuckey SL,
Goh TD,
Heffernan T,
et al
. Hyperintensity in the subarachnoid space on FLAIR MRI. AJR Am J Roentgenol 2007;189:913–21
CrossRef PubMed

[96] Stuckey SL,

[97] Goh TD,

[98] Heffernan T,

[99] et al

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