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Research ArticleTechnical Note
Open Access

Quantitative Assessment of Chronic Thalamic Stroke

G. Pergola, B. Suchan, B. Koch, M. Schwarz, I. Daum and O. Güntürkün
American Journal of Neuroradiology May 2013, 34 (5) E51-E55; DOI: https://doi.org/10.3174/ajnr.A2897
G. Pergola
aFrom the Department of Neuropsychology (G.P., B.S., I.D.)
bInternational Graduate School of Neuroscience (G.P., B.S., I.D., O.G.)
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B. Suchan
aFrom the Department of Neuropsychology (G.P., B.S., I.D.)
bInternational Graduate School of Neuroscience (G.P., B.S., I.D., O.G.)
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B. Koch
dDepartment of Neurology (B.K., M.S.), Municipal Hospital Dortmund, Dortmund, Germany.
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M. Schwarz
dDepartment of Neurology (B.K., M.S.), Municipal Hospital Dortmund, Dortmund, Germany.
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I. Daum
aFrom the Department of Neuropsychology (G.P., B.S., I.D.)
bInternational Graduate School of Neuroscience (G.P., B.S., I.D., O.G.)
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O. Güntürkün
bInternational Graduate School of Neuroscience (G.P., B.S., I.D., O.G.)
cDepartment of Biopsychology (O.G.), Ruhr-University Bochum, Bochum, Germany
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  • Fig 1.
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    Fig 1.

    The lesioned and the nonlesioned thalamus after matching.

  • Fig 2.
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    Fig 2.

    The lesioned thalamus has been matched to the atlas. The lesion has been manually traced, bordering the ischemic lacuna. PuT indicates putamen; fx, fornix; GPe, globus pallidus pars externa; ic, internal capsula; iml, medullary lamina; MV, medioventral nucleus of the thalamus; mtt, mammillothalamic tract; VAmc, ventral anterior nucleus of the thalamus, magnocellular portion; VApc, ventral anterior nucleus of the thalamus, magnocellular portion; CeM, center median nucleus of the thalamus; VLpv, ventrolateral nucleus of the thalamus, posteroventral portion; Pf, parafascicular nucleus of the thalamus; CM, centromedian nucleus of the thalamus; CL, centrolateral nucleus of the thalamus; VPM, ventral posterior medial nucleus of the thalamus; VPLa, ventral posterior lateral nucleus of the thalamus, anterior portion; VPLp, ventral posterior lateral nucleus of the thalamus, posterior portion; PuA, anteror pulvinar; PuM, medial pulvinar; PuL, lateral pulvinar; Hb, habenular nucleus of the thalamus; Pin, posterior intralaminar nucleus of the non-lemniscal pathway; Li, limitans nucleus of the thalamus; R, reticular nucleus of the thalamus; Cd, caudate nucleus. (Modified from Morel.8)

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    Fig 3.

    The image is ready for surface measurement. PuT indicates putamen; fx, fornix; GPe, globus pallidus pars externa; ic, internal capsula; iml, medullary lamina; MV, medioventral nucleus of the thalamus; mtt, mammillothalamic tract; VAmc, ventral anterior nucleus of the thalamus, magnocellular portion; VApc, ventral anterior nucleus of the thalamus, magnocellular portion; CeM, center median nucleus of the thalamus; VLpv, ventrolateral nucleus of the thalamus, posteroventral portion; Pf, parafascicular nucleus of the thalamus; CM, centromedian nucleus of the thalamus; CL, centrolateral nucleus of the thalamus; VPM, ventral posterior medial nucleus of the thalamus; VPLa, ventral posterior lateral nucleus of the thalamus; anterior portion; VPLp, ventral posterior lateral nucleus of the thalamus, posterior portion; PuA, anterior pulvinar; PuM, medial pulvinar; PuL, lateral pulvinar; Hb, habenular nucleus of the thalamus; Pin, posterior intralaminar nucleus of the non-lemniscal pathway; Li, limitans nucleus of the thalamus; R, reticular nucleus of the thalamus; Cd, caudate nucleus. (Modified from Morel.8)

  • Fig 4.
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    Fig 4.

    Scatterplot of the data on which statistical analyses and automated classification were based. The data points lying on the x-axis and belonging to the 2 tuberothalamic patients have been incorrectly classified as paramedian.

Tables

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    Table 1:

    Demographic data of the patientsa

    SubjectSexAge (yr)Age at Onset (yr)Time since Lesion (yr)
    P1M79781.3
    P2F71674.0
    P3F70691.0
    P4F78734.7
    P5F56506.0
    P6F57551.7
    P7M67634.0
    P8M68634.6
    P9F71692.0
    P10M453312
    P11F64595.1
    P12F65604.9
    P13F301812
    P14M64612.3
    P15M594712
    P16F67625.0
    P17F61592.2
    P18M544212
    P19M483810
    Average61.756.15.6
    SD12154.0
    • ↵a Patients 1–9 form the tuberothalamic group. Patients 10–19 constitute the paramedian group.

    • View popup
    Table 2:

    Results of the lesion assessmenta

    SubjectRadiologic InspectionAbsolute DamageRelative Damage
    P1Left VLLeft VLLeft VM
    P2Left VA, VL; right VLLeft VA, VL; right MDLeft MID
    P3Left VLLeft VL, ILN
    P4Left VA, VL, MDLeft VA, VL, MDLeft MD, VL, MID
    P5Right VARight VA, MIDRight VA, MID
    P6Right VL, VA, MDRight VL, VA, MDRight VL, VA, MD, MID, ILN
    P7Left MD, bilateral VPLeft MD, Pu; right ILNLeft MD, VP, ILN, MID; right LP, ILN
    P8Left VLLeft VLLeft VL, VM
    P9Left VL, anterior MDLeft MID, MDLeft MID
    P10Right VA, MDRight VA, MD, MIDRight MD, MID
    P11Right MDRight MD, ILNRight MID
    P12Left MD, ILNRight MD, ILNLeft MD, ILN, MID, VM
    P13Left MDLeft MD, MIDLeft MD, MID
    P14Right MDRight MD, ILNRight MID, ILN, VM
    P15Left MDLeft MD, ILNLeft MID
    P16Right MDRight MDRight MD
    P17Right MDRight MD, ILNRight MD, MID, ILN
    P18Left VL, right VL, VALeft VL, right PuLeft VP
    P19Right VL, bilateral MDRight VL, bilateral MD, ILNRight VA, VL, bilateral MD, ILN, MID
    • Note:—Pu indicates pulvinar; VL, ventrolateral nucleus of the thalamus.

    • ↵a First column indicates the results of the radiologic inspection; second column, structures having the greatest volume loss (absolute damage); third column, structures having >10% volume loss (relative damage).

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American Journal of Neuroradiology: 34 (5)
American Journal of Neuroradiology
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1 May 2013
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Cite this article
G. Pergola, B. Suchan, B. Koch, M. Schwarz, I. Daum, O. Güntürkün
Quantitative Assessment of Chronic Thalamic Stroke
American Journal of Neuroradiology May 2013, 34 (5) E51-E55; DOI: 10.3174/ajnr.A2897

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Quantitative Assessment of Chronic Thalamic Stroke
G. Pergola, B. Suchan, B. Koch, M. Schwarz, I. Daum, O. Güntürkün
American Journal of Neuroradiology May 2013, 34 (5) E51-E55; DOI: 10.3174/ajnr.A2897
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