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Research ArticleBrain
Open Access

Sensorimotor Cortex Gamma-Aminobutyric Acid Concentration Correlates with Impaired Performance in Patients with MS

P.K. Bhattacharyya, M.D. Phillips, L.A. Stone, R.A. Bermel and M.J. Lowe
American Journal of Neuroradiology September 2013, 34 (9) 1733-1739; DOI: https://doi.org/10.3174/ajnr.A3483
P.K. Bhattacharyya
aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
bLerner College of Medicine (P.K.B., R.A.B.)
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M.D. Phillips
aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
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L.A. Stone
cDepartment of Neurology (L.A.S., R.A.B.), Cleveland Clinic, Cleveland, Ohio.
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R.A. Bermel
bLerner College of Medicine (P.K.B., R.A.B.)
cDepartment of Neurology (L.A.S., R.A.B.), Cleveland Clinic, Cleveland, Ohio.
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M.J. Lowe
aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
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Article Information

vol. 34 no. 9 1733-1739
DOI 
https://doi.org/10.3174/ajnr.A3483
PubMed 
23493890

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received April 30, 2012
  • Accepted after revision October 24, 2012
  • Published online September 10, 2013.

Copyright & Usage 
© 2013 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. P.K. Bhattacharyyaa,b,
  2. M.D. Phillipsa,
  3. L.A. Stonec,
  4. R.A. Bermelb,c and
  5. M.J. Lowea
  1. aFrom the Imaging Institute (P.K.B., M.D.P., M.J.L.)
  2. bLerner College of Medicine (P.K.B., R.A.B.)
  3. cDepartment of Neurology (L.A.S., R.A.B.), Cleveland Clinic, Cleveland, Ohio.
  1. Please address correspondence to Pallab K. Bhattacharyya, MD, Imaging Institute and Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Ave, U15, Cleveland, OH 44195; e-mail: bhattap{at}ccf.org
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P.K. Bhattacharyya, M.D. Phillips, L.A. Stone, R.A. Bermel, M.J. Lowe
Sensorimotor Cortex Gamma-Aminobutyric Acid Concentration Correlates with Impaired Performance in Patients with MS
American Journal of Neuroradiology Sep 2013, 34 (9) 1733-1739; DOI: 10.3174/ajnr.A3483

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Sensorimotor Cortex Gamma-Aminobutyric Acid Concentration Correlates with Impaired Performance in Patients with MS
P.K. Bhattacharyya, M.D. Phillips, L.A. Stone, R.A. Bermel, M.J. Lowe
American Journal of Neuroradiology Sep 2013, 34 (9) 1733-1739; DOI: 10.3174/ajnr.A3483
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Cited By...

  • Genetic ablation of GABAB receptors from oligodendrocyte precursor cells protects against demyelination in the mouse spinal cord
  • {gamma}-aminobutyrate (GAB) functions as a bioenergetic and signaling gatekeeper to control T cell inflammation
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Reduced gamma-aminobutyric acid concentration is associated with physical disability in progressive multiple sclerosis
    Niamh Cawley, Bhavana S. Solanky, Nils Muhlert, Carmen Tur, Richard A. E. Edden, Claudia A. M. Wheeler-Kingshott, David H. Miller, Alan J. Thompson, Olga Ciccarelli
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  • GABA levels and measures of intracortical and interhemispheric excitability in healthy young and older adults: an MRS-TMS study
    Lize Hermans, Oron Levin, Celine Maes, Peter van Ruitenbeek, Kirstin-Friederike Heise, Richard A.E. Edden, Nicolaas A.J. Puts, Ronald Peeters, Bradley R. King, Raf L.J. Meesen, Inge Leunissen, Stephan P. Swinnen, Koen Cuypers
    Neurobiology of Aging 2018 65
  • Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis
    Guanmei Cao, Richard A. E. Edden, Fei Gao, Hao Li, Tao Gong, Weibo Chen, Xiaohui Liu, Guangbin Wang, Bin Zhao
    European Radiology 2018 28 3
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    Kelley M. Swanberg, Karl Landheer, David Pitt, Christoph Juchem
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  • GABA, Glutamate and Neural Activity: A Systematic Review With Meta-Analysis of Multimodal 1H-MRS-fMRI Studies
    Amanda Kiemes, Cathy Davies, Matthew J. Kempton, Paulina B. Lukow, Carly Bennallick, James M. Stone, Gemma Modinos
    Frontiers in Psychiatry 2021 12
  • Brain-derived neurotropic factor and GABAergic transmission in neurodegeneration and neuroregeneration
    Jinwook Kim, Sueun Lee, Sohi Kang, Sung-Ho Kim, Jong-Choon Kim, Miyoung Yang, Changjong Moon
    Neural Regeneration Research 2017 12 10
  • Thalamic GABA Predicts Fine Motor Performance in Manganese-Exposed Smelter Workers
    Zaiyang Long, Xiang-Rong Li, Jun Xu, Richard A. E. Edden, Wei-Ping Qin, Li-Ling Long, James B. Murdoch, Wei Zheng, Yue-Ming Jiang, Ulrike Dydak, Fanis Missirlis
    PLoS ONE 2014 9 2
  • GABA and glutamate levels correlate with MTR and clinical disability: Insights from multiple sclerosis
    Julia C. Nantes, Sébastien Proulx, Jidan Zhong, Scott A. Holmes, Sridar Narayanan, Robert A. Brown, Richard D. Hoge, Lisa Koski
    NeuroImage 2017 157
  • Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis
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    Hippocampus 2018 28 11
  • Imaging Mechanisms of Disease Progression in Multiple Sclerosis: Beyond Brain Atrophy
    Francesca Bagnato, Susan A. Gauthier, Cornelia Laule, George R. Wayne Moore, Riley Bove, Zhengxin Cai, Julien Cohen‐Adad, Daniel M. Harrison, Eric C. Klawiter, Sarah A. Morrow, Gülin Öz, William D. Rooney, Seth A. Smith, Peter A. Calabresi, Roland G. Henry, Jiwon Oh, Daniel Ontaneda, Daniel Pelletier, Daniel S. Reich, Russell T. Shinohara, Nancy L. Sicotte
    Journal of Neuroimaging 2020 30 3

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