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Optimal Contrast Concentration for CT-Guided Epidural Steroid Injections

P.G. Kranz, M. Abbott, D. Abbott and J.K. Hoang
American Journal of Neuroradiology January 2014, 35 (1) 191-195; DOI: https://doi.org/10.3174/ajnr.A3626
P.G. Kranz
aFrom the Departments of Radiology (P.G.K., M.A., J.K.H.)
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M. Abbott
aFrom the Departments of Radiology (P.G.K., M.A., J.K.H.)
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D. Abbott
bBiostatistics and Bioinformatics (D.A.), Duke University Medical Center, Durham, North Carolina.
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J.K. Hoang
aFrom the Departments of Radiology (P.G.K., M.A., J.K.H.)
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  • Fig 1.
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    Fig 1.

    Phantom study assessing needle visibility. A, Scout image from CT demonstrating the configuration of the phantom. The central chamber houses contrast and a 22-gauge needle. Axial cross-sectional images of the chamber are shown with various contrast dilutions: 50 mg/mL (B), 66 mg/mL (C), 100 mg/mL (D), 133 mg/mL (E), and 150 mg/mL (F).

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    Fig 2.

    Axial CTF images show representative examples of visibility scores on the basis of our 5-point scoring system. A, Score of +2. The contrast is too dense to visualize the location of the needle tip. B, Score of 0. The needle tip can be distinguished from the injected contrast; adequate soft tissue contrast is also provided. C, Score of −2. The injected contrast is too dilute to provide adequate soft tissue contrast.

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    Fig 3.

    Importance of precise needle placement in cervical epidural steroid injections. A, Axial CTF image obtained before contrast injection. B, Image obtained immediately after contrast injection shows transient filling of small vessels (arrows). No epidural spread is seen. C, Image obtained after advancing the needle <2 mm demonstrates foraminal epidural contrast spread, with no vascular filling. Note the close proximity of the needle tip to the vertebral artery (*). This case highlights the importance of accurate localization of the needle tip and the need to be able to make small but precise adjustments in needle position during epidural injections.

Tables

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    Table 1:

    Five-point scoring system for the clinical study

    Too ConcentratedOptimalToo Dilute
    Visibility score+2+10−1−2
    Needle tipNot visibleBorderlineVisibleVisibleVisible
    Soft tissue contrastAdequateAdequateAdequateBorderlineNot acceptable
    • View popup
    Table 2:

    Visibility scores for the clinical study

    Visibility Score
    −2−10+1+2
    Total scores (n = 120)n = 9n = 10n = 34n = 25n = 42
    (2 readers)(7.5%)(8.3%)(28.3%)(20.8%)(35.0%)
    Iodine concentration
        66 mg/mL (n = 34)n = 7n = 5n = 15n = 6n = 1
    (20.6%)(14.7%)(44.1%)(17.6%)(2.9%)
        100 mg/mL (n = 32)n = 2n = 5n = 9n = 10n = 6
    (6.3%)(15.6%)(28.1%)(31.3%)(18.8%)
        133 mg/mL (n = 26)n = 0n = 0n = 2n = 3n = 21
    (0%)(0%)(7.7%)(11.5%)(80.8%)
        150 mg/mL (n = 28)n = 0n = 0n = 8n = 6n = 14
    (0%)(0%)(28.6%)(21.4%)(50.0%)
    Injection technique
        ILESI (n = 64)n = 0n = 3n = 14n = 17n = 30
    (0%)(4.7%)(21.9%)(26.6%)(46.9%)
        TFESI (n = 56)n = 9n = 7n = 20n = 8n = 12
    (16.1%)(12.5%)(35.7%)(14.3%)(21.4%)
    • View popup
    Table 3:

    Comparison of visibility scores on the basis of combined iodine concentration and injection technique

    Iodine Concentration + Injection TechniqueP Valuea
    (66 mg/mL and TFESI) versus (100 mg/mL and TFESI).011
    (66 mg/mL and ILESI) versus (100 mg/mL and ILESI).016
    (66 mg/mL and ILESI) versus (66 mg/mL and TFESI).051
    (100 mg/mL and ILESI) versus (100 mg/mL and TFESI).021
    • ↵a P values are based on results of generalized estimating equations test of difference contrast statements with the use of a Bonferroni-corrected significance threshold of 0.0083.

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American Journal of Neuroradiology: 35 (1)
American Journal of Neuroradiology
Vol. 35, Issue 1
1 Jan 2014
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Cite this article
P.G. Kranz, M. Abbott, D. Abbott, J.K. Hoang
Optimal Contrast Concentration for CT-Guided Epidural Steroid Injections
American Journal of Neuroradiology Jan 2014, 35 (1) 191-195; DOI: 10.3174/ajnr.A3626

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Optimal Contrast Concentration for CT-Guided Epidural Steroid Injections
P.G. Kranz, M. Abbott, D. Abbott, J.K. Hoang
American Journal of Neuroradiology Jan 2014, 35 (1) 191-195; DOI: 10.3174/ajnr.A3626
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