Article Figures & Data
Figures
- Fig 1.
Right hemisphere, lateral surface. Areas showing a significant cortical thinning in patients with ALS (P < .05) are colored in blue. Areas 1–4 are localized in the frontal region. Area 5 is localized in the temporal region.
- Fig 2.
Left hemisphere, lateral surface. Areas showing a significant cortical thinning in patients with ALS (P < .05) are colored in blue. Areas 1–11 are localized in the frontal region. CTh in area 1 (orbitofrontal lateral cortex) correlated with disease disability (P = .04).
- Fig 3.
Right hemisphere, medial surface. Areas showing a significant cortical thinning in patients with ALS (P < .05) are colored in blue. Areas 1–4 are localized in the frontal region. Areas 5 and 8 are localized in the temporal region. Areas 6 and 7 are localized in the parietooccipital region. CTh in area 4 (premotor cortex) correlated with disease duration (P = .007).
- Fig 4.
Left hemisphere, medial surface. Areas showing a significant cortical thinning in patients with ALS (P < .05) are colored in blue. Areas 1–4 are localized in the frontal region. Areas 7 and 8 are localized in the temporal region. Areas 5 and 6 are localized in the parietooccipital region. CTh in area 8 (inferior temporal and parahippocampal cortex) correlated with the rate of disease progression (P = .0265).
Tables
Group HC ALS n 18 20 M/F 10/8 10/10 Mean age, y (SD) 60 (10.5) 61.5 (9.1) Disease duration, mean y (SD) n/a 2.6 (2.7) Upper limbs onset n/a 10 Lower limbs onset n/a 10 ALSFRS-R, mean (SD) n/a 36.2 (8.7) 48-ALSFRS-R/months of disease duration, mean (SD) n/a 0.64 (0.7) UMN score, mean (SD) n/a 7.1 (3.9) FrSBe, mean (SD) n/a 102.3 (18.5) Note:—n/a indicates not applicable; SD, standard deviation.
- Table 2:
Spatial coordinates, extent, and average CTh of areas showing significant cortical thinning between patients with ALS and HCs
Area Talairach Coordinates (x, y, z) Surface Extension (mm2) ALS Mean CTh (mm) HC Mean CTh (mm) Right hemisphere, lateral surface (see Fig 1 for reference) 1 0, 97, −35 178 2.778 2.891 2 13, 74, −33 713 2.482 2.687 3 −12, −2, 69 39 2.462 2.793 4 22, 13, 39 15 2.662 2.952 5 23, 27, −69 269 3.152 3.387 Left hemisphere, lateral surface (see Fig 2 for reference) 1 5, 85, −45 501 2.398 2.651 2 −13, 78, −32 37 3.050 3.134 3 −14, 88, −17 65 2.039 2.323 4 −20, 73, −3 206 1.860 2.116 5 −12, 76, 13 69 2.527 2.796 6 −12, 38, −42 175 3.350 3.652 7 −14, 37, −16 154 2.271 2.434 8 −22, 3, 43 22 1.389 1.557 9 11, 28, 61 57 2.164 2.522 10 −40, −4, 15 232 2.569 2.817 11 −33, −21, 31 152 2.293 2.507 Right hemisphere, medial surface (see Fig 3 for reference) 1 −32, 82, 0 116 2.250 2.516 2 −31, 62, 26 131 2.347 2.510 3 −31, 40, 40 139 2.336 2.664 4 −31, 15, 38 67 2.187 2.450 5 2, 11, −64 159 3.342 3.970 6 −29, −57, 18 72 2.536 2.724 7 −25, −93, −19 204 1.571 1.797 8 17, −44, −52 65 2.697 2.928 Left hemisphere, medial surface (see Fig 4 for reference) 1 28, 93, −39 179 2.288 2.668 2 33, 51, 24 55 2.063 2.509 3 30, 41, 49 40 2.769 2.929 4 28, 13, 66 44 2.407 2.747 5 28, −68, 25 67 2.411 2.614 6 28, −63, 17 43 2.634 2.769 7 20, −102, −28 155 1.685 1.826 8 −4, −3, −64 558 3.012 3.470
