Research ArticleBrain
Open Access
Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study
R. Cappellani, N. Bergsland, B. Weinstock-Guttman, C. Kennedy, E. Carl, D.P. Ramasamy, J. Hagemeier, M.G. Dwyer, F. Patti and R. Zivadinov
American Journal of Neuroradiology May 2014, 35 (5) 912-919; DOI: https://doi.org/10.3174/ajnr.A3788
R. Cappellani
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
cDepartment GF Ingrassia, Section of Neurosciences (R.C., F.P.), University of Catania, Catania, Italy.
N. Bergsland
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
B. Weinstock-Guttman
bJacobs Neurological Institute, Department of Neurology (B.W.-G., R.Z.), State University of New York, Buffalo, New York
C. Kennedy
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
E. Carl
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
D.P. Ramasamy
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
J. Hagemeier
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
M.G. Dwyer
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
F. Patti
cDepartment GF Ingrassia, Section of Neurosciences (R.C., F.P.), University of Catania, Catania, Italy.
R. Zivadinov
aFrom the Buffalo Neuroimaging Analysis Center (R.C., N.B., C.K., E.C., D.P.R., J.H., M.G.D., R.Z.)
bJacobs Neurological Institute, Department of Neurology (B.W.-G., R.Z.), State University of New York, Buffalo, New York

Article Information
vol. 35 no. 5 912-919
PubMed
Published By
Print ISSN
Online ISSN
Copyright & Usage
© 2014 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org
Altmetrics
Cited By...
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Alvino Bisecco, Maria A. Rocca, Elisabetta Pagani, Laura Mancini, Christian Enzinger, Antonio Gallo, Hugo Vrenken, Maria Laura Stromillo, Massimiliano Copetti, David L. Thomas, Franz Fazekas, Gioacchino Tedeschi, Frederik Barkhof, Nicola De Stefano, Massimo FilippiHuman Brain Mapping 2015 36 7
- Frank C.G. van Bussel, Walter H. Backes, Tamar M. van Veenendaal, Paul A.M. Hofman, Martin P.J. van Boxtel, Miranda T. Schram, Simone J.S. Sep, Pieter C. Dagnelie, Nicolaas Schaper, Coen D.A. Stehouwer, Joachim E. Wildberger, Jacobus F.A. JansenDiabetes 2016 65 8
- Laëtitia Debernard, Tracy R. Melzer, Sridhar Alla, Jane Eagle, Saskia Van Stockum, Charlotte Graham, Jonathan R. Osborne, John C. Dalrymple-Alford, David H. Miller, Deborah F. MasonPsychiatry Research: Neuroimaging 2015 234 3
- Shannon E. Dunn, Eva Gunde, Hyunwoo Lee2015 26
- F. C. G. van Bussel, W. H. Backes, P. A. M. Hofman, M. P. J. van Boxtel, M. T. Schram, C. D. A. Stehouwer, J. E. Wildberger, J. F. A. JansenJournal of Neuroendocrinology 2016 28 3
- Peter Lee, Hojin Ryoo, Jinah Park, Yong JeongJournal of Clinical Neurology 2017 13 2
- Niels Bergsland, Maria Marcella Laganà, Eleonora Tavazzi, Matteo Caffini, Paola Tortorella, Francesca Baglio, Giuseppe Baselli, Marco RovarisMultiple Sclerosis Journal 2015 21 14
- Dimitrios Karussis, Panayiota PetrouImmunologic Research 2018 66 6
- Elizabeth A. Hubbard, Nathan C. Wetter, Bradley P. Sutton, Lara A. Pilutti, Robert W. MotlJournal of the Neurological Sciences 2016 363
- Sarah Treit, Trevor Steve, Donald W. Gross, Christian BeaulieuNeuroImage 2018 182
- A.F. Kuceyeski, W. Vargas, M. Dayan, E. Monohan, C. Blackwell, A. Raj, K. Fujimoto, S.A. GauthierAmerican Journal of Neuroradiology 2015 36 4
- Dejan Jakimovski, Bianca Weinstock-Guttman, Jesper Hagemeier, Caila B. Vaughn, Katelyn S. Kavak, Sirin Gandhi, Susan E. Bennett, Tom A. Fuchs, Niels Bergsland, Michael G. Dwyer, Ralph H.B. Benedict, Robert ZivadinovJournal of the Neurological Sciences 2018 393
- Yanis Taege, Jesper Hagemeier, Niels Bergsland, Michael G. Dwyer, Bianca Weinstock-Guttman, Robert Zivadinov, Ferdinand SchweserNeuroImage 2019 186
- Julia Krämer, Wolfgang Brück, Frauke Zipp, Manuela Cerina, Sergiu Groppa, Sven G. MeuthProgress in Neurobiology 2019 182
- Niels Bergsland, Ferdinand Schweser, Michael G. Dwyer, Bianca Weinstock‐Guttman, Ralph H. B. Benedict, Robert ZivadinovHuman Brain Mapping 2018 39 10
- Nicholas Riccardi, Grigori Yourganov, Chris Rorden, Julius Fridriksson, Rutvik DesaiJournal of Cognitive Neuroscience 2020 32 3
- Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Ellen Carl, Hanna Kolb, David Hojnacki, Bianca Weinstock-GuttmanJournal of the Neurological Sciences 2018 388
- Olavi Misin, Markus Matilainen, Marjo Nylund, Eveliina Honkonen, Eero Rissanen, Marcus Sucksdorff, Laura AirasNeurology Neuroimmunology & Neuroinflammation 2022 9 4
- Fuqing Zhou, Honghan Gong, Qi Chen, Bo Wang, Yan Peng, Ying Zhuang, Chi-shing ZeeFrontiers in Human Neuroscience 2016 10
- M. Varosanec, T. Uher, D. Horakova, J. Hagemeier, N. Bergsland, M. Tyblova, Z. Seidl, M. Vaneckova, J. Krasensky, M.G. Dwyer, E. Havrdova, R. ZivadinovAmerican Journal of Neuroradiology 2015 36 8
- Ismail Koubiyr, Mathilde Deloire, Pierrick Coupé, Cécile Dulau, Pierre Besson, Amandine Moroso, Vincent Planche, Thomas Tourdias, Bruno Brochet, Aurélie RuetFrontiers in Neurology 2018 9
- Diana Valdés Cabrera, Penelope Smyth, Gregg Blevins, Derek Emery, Christian BeaulieuEuropean Journal of Neuroscience 2022 55 1
- Charlie C. Park, Dean W. Thongkham, Gelareh Sadigh, Amit M. Saindane, Renxin Chu, Rohit Bakshi, Jason W. Allen, Ranliang HuJournal of Neuroimaging 2021 31 2
- Reserve-building activities in multiple sclerosis patients and healthy controls: a descriptive studyCarolyn E. Schwartz, Armon Ayandeh, Murali Ramanathan, Ralph Benedict, Michael G. Dwyer, Bianca Weinstock-Guttman, Robert ZivadinovBMC Neurology 2015 15 1
- Ramona Woitek, Fritz Leutmezer, Assunta Dal-Bianco, Julia Furtner, Gregor Kasprian, Daniela Prayer, Veronika SchöpfActa Radiologica 2020 61 1
- Diana Valdés Cabrera, Gregg Blevins, Penelope Smyth, Derek Emery, Kevin Grant Solar, Christian BeaulieuNMR in Biomedicine 2023 36 9
- Mohamed D. Homos, Mohamed Talaat Ali, Mohamed Fouad Osman, Doaa Mohamed NabilThe Egyptian Journal of Radiology and Nuclear Medicine 2017 48 4
- Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Eleonora Tavazzi, Deepa P. Ramasamy, Jackie Durfee, Mariya Cherneva, Ellen Carl, Jillian Carl, Channa Kolb, David Hojnacki, Bianca Weinstock-GuttmanJournal of the Neurological Sciences 2018 387
- P Nwaubani, M Cercignani, A ColasantiClinical and Experimental Immunology 2022 210 1
- Carolyn E. Schwartz, Michael G. Dwyer, Ralph Benedict, Bianca Weinstock-Guttman, Niels P. Bergsland, Jei Li, Murali Ramanathan, Robert ZivadinovBMC Neurology 2016 16 1
- AmirEhsan Lashkari, Esmaeil Davoodi-Bojd, Lara Fahmy, Lian Li, Siamak P. Nejad-Davarani, Michael Chopp, Quan Jiang, Mirela CerghetClinical Neurology and Neurosurgery 2021 201
- Hui Hong, Shuyue Wang, Xinfeng Yu, Yeerfan Jiaerken, Xiaojun Guan, Qingze Zeng, Xinzhen Yin, Ruiting Zhang, Yao Zhang, Zili Zhu, Peiyu Huang, Minming ZhangJournal of Magnetic Resonance Imaging 2023 57 1
- Ping Yin, Yi Liu, Hua Xiong, Yongliang Han, Shambhu Kumar Sah, Chun Zeng, Jingjie Wang, Yongmei LiThe British Journal of Radiology 2018 91 1083
- Mohammad Amiri, Reza Gerami, Babak Shekarchi, Amirreza Azimi, Bahador Asadi, Hamed BagheriEuropean Journal of Radiology Open 2023 10
- Artur Tadeusz Krzyżak, Julia Lasek, Zofia Schneider, Marcin Wnuk, Amira Bryll, Tadeusz Popiela, Agnieszka SłowikNeuroImage 2024 290
- Shaun Andrew Hanycz, Alborz Noorani, Peter Shih-Ping Hung, Matthew R. Walker, Ashley B. Zhang, Timur H. Latypov, Mojgan HodaiePAIN Reports 2024 9 3
- Giordano Gentile, Rozemarijn M. Mattiesing, Iman Brouwer, Ronald A. van Schijndel, Bernard M.J. Uitdehaag, Jos W.R. Twisk, Ludwig Kappos, Mark S. Freedman, Giancarlo Comi, Dominic Jack, Frederik Barkhof, Nicola De Stefano, Hugo Vrenken, Marco BattagliniNeuroImage: Clinical 2023 38
- Mohamed D. HomosEgyptian Journal of Radiology and Nuclear Medicine 2021 52 1
- Francesco Romanò, Paola Valsasina, Elisabetta Pagani, Alice De Simone, Emma Parolin, Massimo Filippi, Maria A. RoccaMultiple Sclerosis and Related Disorders 2024 86
In this issue
American Journal of Neuroradiology
Vol. 35, Issue 5
1 May 2014
Advertisement
R. Cappellani, N. Bergsland, B. Weinstock-Guttman, C. Kennedy, E. Carl, D.P. Ramasamy, J. Hagemeier, M.G. Dwyer, F. Patti, R. Zivadinov
Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study
American Journal of Neuroradiology May 2014, 35 (5) 912-919; DOI: 10.3174/ajnr.A3788
0 Responses
Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study
R. Cappellani, N. Bergsland, B. Weinstock-Guttman, C. Kennedy, E. Carl, D.P. Ramasamy, J. Hagemeier, M.G. Dwyer, F. Patti, R. Zivadinov
American Journal of Neuroradiology May 2014, 35 (5) 912-919; DOI: 10.3174/ajnr.A3788
Related Articles
Cited By...
- Innate Immune Cell-Related Pathology in the Thalamus Signals a Risk for Disability Progression in Multiple Sclerosis
- Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study
- Longitudinal Mixed-Effect Model Analysis of the Association between Global and Tissue-Specific Brain Atrophy and Lesion Accumulation in Patients with Clinically Isolated Syndrome
- Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis
This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.
- Alvino Bisecco, Maria A. Rocca, Elisabetta Pagani, Laura Mancini, Christian Enzinger, Antonio Gallo, Hugo Vrenken, Maria Laura Stromillo, Massimiliano Copetti, David L. Thomas, Franz Fazekas, Gioacchino Tedeschi, Frederik Barkhof, Nicola De Stefano, Massimo FilippiHuman Brain Mapping 2015 36 7
- Frank C.G. van Bussel, Walter H. Backes, Tamar M. van Veenendaal, Paul A.M. Hofman, Martin P.J. van Boxtel, Miranda T. Schram, Simone J.S. Sep, Pieter C. Dagnelie, Nicolaas Schaper, Coen D.A. Stehouwer, Joachim E. Wildberger, Jacobus F.A. JansenDiabetes 2016 65 8
- Laëtitia Debernard, Tracy R. Melzer, Sridhar Alla, Jane Eagle, Saskia Van Stockum, Charlotte Graham, Jonathan R. Osborne, John C. Dalrymple-Alford, David H. Miller, Deborah F. MasonPsychiatry Research: Neuroimaging 2015 234 3
- Shannon E. Dunn, Eva Gunde, Hyunwoo Lee2015 26
- F. C. G. van Bussel, W. H. Backes, P. A. M. Hofman, M. P. J. van Boxtel, M. T. Schram, C. D. A. Stehouwer, J. E. Wildberger, J. F. A. JansenJournal of Neuroendocrinology 2016 28 3
- Peter Lee, Hojin Ryoo, Jinah Park, Yong JeongJournal of Clinical Neurology 2017 13 2
- Niels Bergsland, Maria Marcella Laganà, Eleonora Tavazzi, Matteo Caffini, Paola Tortorella, Francesca Baglio, Giuseppe Baselli, Marco RovarisMultiple Sclerosis Journal 2015 21 14
- Dimitrios Karussis, Panayiota PetrouImmunologic Research 2018 66 6
- Elizabeth A. Hubbard, Nathan C. Wetter, Bradley P. Sutton, Lara A. Pilutti, Robert W. MotlJournal of the Neurological Sciences 2016 363
- Sarah Treit, Trevor Steve, Donald W. Gross, Christian BeaulieuNeuroImage 2018 182
More in this TOC Section
Similar Articles
Advertisement