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Research ArticleLevel 1 EBM Expedited Publication
Open Access

Are There Differences between Macrocyclic Gadolinium Contrast Agents for Brain Tumor Imaging? Results of a Multicenter Intraindividual Crossover Comparison of Gadobutrol with Gadoteridol (the TRUTH Study)

K.R. Maravilla, M.P. Smith, J. Vymazal, M. Goyal, M. Herman, J.J. Baima, R. Babbel, M. Vaneckova, J. Žižka, C. Colosimo, M. Urbańczyk-Zawadzka, M. Mechl, A.K. Bag, S. Bastianello, E. Bueltmann, T. Hirai, T. Frattini, M.A. Kirchin and G. Pirovano
American Journal of Neuroradiology January 2015, 36 (1) 14-23; DOI: https://doi.org/10.3174/ajnr.A4154
K.R. Maravilla
aFrom the MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington
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M.P. Smith
bDepartment of Radiology (M.P.S.), Beth Israel Deaconess Medical Center, Boston, Massachusetts
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J. Vymazal
cDepartment of Radiology (J.V.), Na Homolce Hospital, Prague, Czech Republic
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M. Goyal
dSeaman Family MR Research Centre (M.G.), University of Calgary, Calgary, Alberta, Canada
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M. Herman
eDepartment of Radiology (M.H.), University Hospital Olomouc, Olomouc, Czech Republic
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J.J. Baima
fClinical Radiologists Service Corporation (J.J.B.), Memorial Medical Center, Springfield, Illinois
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R. Babbel
gGood Samaritan Regional Medical Center (R.B.), Corvallis, Oregon
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M. Vaneckova
hDepartment of Magnetic Resonance (M.V.), General University Hospital, Prague, Czech Republic
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J. Žižka
iDepartment of Diagnostic Radiology (J.Ž.), University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové, Charles University, Prague, Czech Republic
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C. Colosimo
jIstituto di Radiologia (C.C.), Policlinico “Agostino Gemelli,” Rome, Italy
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M. Urbańczyk-Zawadzka
kDepartment of Radiology (M.U.-Z.), John Paul II Hospital, Krakow, Poland
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M. Mechl
lDepartment of Radiology (M.M.), University Hospital Brno-Bohunice, Brno, Czech Republic
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A.K. Bag
mDepartment of Radiology (A.K.B.), University of Alabama at Birmingham Medical Center, Birmingham, Alabama
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S. Bastianello
nDepartment of Neuroradiology (S.B), University of Pavia, Pavia, Italy
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E. Bueltmann
oInstitute for Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany
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T. Hirai
pDepartment of Diagnostic Radiology (T.H.), Kumamoto University, Honjo, Kumamoto, Japan
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T. Frattini
qOspedale Valduce (T.F.), Como, Italy
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M.A. Kirchin
rGlobal Medical and Regulatory Affairs (M.A.K.), Bracco Imaging SpA, Milan, Italy
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G. Pirovano
sGlobal Medical and Regulatory Affairs (G.P.), Bracco Diagnostics, Monroe, New Jersey.
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Article Information

vol. 36 no. 1 14-23
DOI 
https://doi.org/10.3174/ajnr.A4154
PubMed 
25300984

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received August 7, 2014
  • Accepted after revision September 15, 2014
  • Published online January 13, 2015.

Copyright & Usage 
© 2015 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. K.R. Maravillaa,
  2. M.P. Smithb,
  3. J. Vymazalc,
  4. M. Goyald,
  5. M. Hermane,
  6. J.J. Baimaf,
  7. R. Babbelg,
  8. M. Vaneckovah,
  9. J. Žižkai,
  10. C. Colosimoj,
  11. M. Urbańczyk-Zawadzkak,
  12. M. Mechll,
  13. A.K. Bagm,
  14. S. Bastianellon,
  15. E. Bueltmanno,
  16. T. Hiraip,
  17. T. Frattiniq,
  18. M.A. Kirchinr and
  19. G. Pirovanos
  1. aFrom the MR Research Laboratory (K.R.M.), University of Washington, Seattle, Washington
  2. bDepartment of Radiology (M.P.S.), Beth Israel Deaconess Medical Center, Boston, Massachusetts
  3. cDepartment of Radiology (J.V.), Na Homolce Hospital, Prague, Czech Republic
  4. dSeaman Family MR Research Centre (M.G.), University of Calgary, Calgary, Alberta, Canada
  5. eDepartment of Radiology (M.H.), University Hospital Olomouc, Olomouc, Czech Republic
  6. fClinical Radiologists Service Corporation (J.J.B.), Memorial Medical Center, Springfield, Illinois
  7. gGood Samaritan Regional Medical Center (R.B.), Corvallis, Oregon
  8. hDepartment of Magnetic Resonance (M.V.), General University Hospital, Prague, Czech Republic
  9. iDepartment of Diagnostic Radiology (J.Ž.), University Hospital Hradec Králové and Faculty of Medicine in Hradec Králové, Charles University, Prague, Czech Republic
  10. jIstituto di Radiologia (C.C.), Policlinico “Agostino Gemelli,” Rome, Italy
  11. kDepartment of Radiology (M.U.-Z.), John Paul II Hospital, Krakow, Poland
  12. lDepartment of Radiology (M.M.), University Hospital Brno-Bohunice, Brno, Czech Republic
  13. mDepartment of Radiology (A.K.B.), University of Alabama at Birmingham Medical Center, Birmingham, Alabama
  14. nDepartment of Neuroradiology (S.B), University of Pavia, Pavia, Italy
  15. oInstitute for Diagnostic and Interventional Neuroradiology (E.B.), Hannover, Germany
  16. pDepartment of Diagnostic Radiology (T.H.), Kumamoto University, Honjo, Kumamoto, Japan
  17. qOspedale Valduce (T.F.), Como, Italy
  18. rGlobal Medical and Regulatory Affairs (M.A.K.), Bracco Imaging SpA, Milan, Italy
  19. sGlobal Medical and Regulatory Affairs (G.P.), Bracco Diagnostics, Monroe, New Jersey.
  1. Please address correspondence to Kenneth R. Maravilla, MD, Radiology and Neurological Surgery, MR Research Laboratory, University of Washington, 1959 NE Pacific, Box 357115, Seattle, WA 98195; e-mail: kmarav{at}uw.edu
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K.R. Maravilla, M.P. Smith, J. Vymazal, M. Goyal, M. Herman, J.J. Baima, R. Babbel, M. Vaneckova, J. Žižka, C. Colosimo, M. Urbańczyk-Zawadzka, M. Mechl, A.K. Bag, S. Bastianello, E. Bueltmann, T. Hirai, T. Frattini, M.A. Kirchin, G. Pirovano
Are There Differences between Macrocyclic Gadolinium Contrast Agents for Brain Tumor Imaging? Results of a Multicenter Intraindividual Crossover Comparison of Gadobutrol with Gadoteridol (the TRUTH Study)
American Journal of Neuroradiology Jan 2015, 36 (1) 14-23; DOI: 10.3174/ajnr.A4154

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Are There Differences between Macrocyclic Gadolinium Contrast Agents for Brain Tumor Imaging? Results of a Multicenter Intraindividual Crossover Comparison of Gadobutrol with Gadoteridol (the TRUTH Study)
K.R. Maravilla, M.P. Smith, J. Vymazal, M. Goyal, M. Herman, J.J. Baima, R. Babbel, M. Vaneckova, J. Žižka, C. Colosimo, M. Urbańczyk-Zawadzka, M. Mechl, A.K. Bag, S. Bastianello, E. Bueltmann, T. Hirai, T. Frattini, M.A. Kirchin, G. Pirovano
American Journal of Neuroradiology Jan 2015, 36 (1) 14-23; DOI: 10.3174/ajnr.A4154
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  • Comparison of Dynamic Contrast-Enhancement Parameters between Gadobutrol and Gadoterate Meglumine in Posttreatment Glioma: A Prospective Intraindividual Study
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