Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

C.M. Modica; R. Zivadinov; M.G. Dwyer; N. Bergsland; A.R. Weeks; R.H.B. Benedict

doi:10.3174/ajnr.A3998

Research ArticleBrain

Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

C.M. Modica, R. Zivadinov, M.G. Dwyer, N. Bergsland, A.R. Weeks and R.H.B. Benedict

American Journal of Neuroradiology January 2015, 36 (1) 57-62; DOI: https://doi.org/10.3174/ajnr.A3998

C.M. Modica

aFrom the Neuroscience Program (C.M.M.)

bBuffalo Neuroimaging Analysis Center (C.M.M., R.Z., M.G.D., N.B., R.H.B.B.)

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

R. Zivadinov

bBuffalo Neuroimaging Analysis Center (C.M.M., R.Z., M.G.D., N.B., R.H.B.B.)

cMR Imaging Clinical Translational Research Center (R.Z.)

dDepartment of Neurology (R.Z., R.H.B.B.), School of Medicine and Biomedical Sciences

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

M.G. Dwyer

bBuffalo Neuroimaging Analysis Center (C.M.M., R.Z., M.G.D., N.B., R.H.B.B.)

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

N. Bergsland

bBuffalo Neuroimaging Analysis Center (C.M.M., R.Z., M.G.D., N.B., R.H.B.B.)

fIRCCS (N.B.), “S. Maria Nascente,” Don Gnocchi Foundation, Milan, Italy.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

A.R. Weeks

eSchool of Public Health and Health Professions (A.R.W.), University at Buffalo, State University of New York, Buffalo, New York

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

R.H.B. Benedict

bBuffalo Neuroimaging Analysis Center (C.M.M., R.Z., M.G.D., N.B., R.H.B.B.)

dDepartment of Neurology (R.Z., R.H.B.B.), School of Medicine and Biomedical Sciences

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Article
Figures & Data
Info & Metrics
Responses
References
PDF

Article Information

vol. 36 no. 1 57-62

DOI

https://doi.org/10.3174/ajnr.A3998

PubMed

24948507

Published By

American Journal of Neuroradiology

Print ISSN

0195-6108

Online ISSN

1936-959X

History

Received November 18, 2013
Accepted after revision April 7, 2014
Published online January 13, 2015.

Author Information

C.M. Modicaa,b,
R. Zivadinovb,c,d,
M.G. Dwyerb,
N. Bergslandb,f,
A.R. Weekse and
R.H.B. Benedictb,d

^aFrom the Neuroscience Program (C.M.M.)
^bBuffalo Neuroimaging Analysis Center (C.M.M., R.Z., M.G.D., N.B., R.H.B.B.)
^cMR Imaging Clinical Translational Research Center (R.Z.)
^dDepartment of Neurology (R.Z., R.H.B.B.), School of Medicine and Biomedical Sciences
^eSchool of Public Health and Health Professions (A.R.W.), University at Buffalo, State University of New York, Buffalo, New York
^fIRCCS (N.B.), “S. Maria Nascente,” Don Gnocchi Foundation, Milan, Italy.

Please address correspondence to Ralph H.B. Benedict, PhD, SUNY Buffalo Neurology, 100 High St, Suite E2, Buffalo, NY 14203; e-mail: benedict{at}buffalo.edu

View Full Text

Altmetrics

Cited By...

32 Citations
34 Citations
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping Imaging

Yeonsil Moon, Seol-Heui Han, Won-Jin Moon

Journal of Alzheimer's Disease 2016 51 3
Iron chelation in the treatment of neurodegenerative diseases

Petr Dusek, Susanne A. Schneider, Jan Aaseth

Journal of Trace Elements in Medicine and Biology 2016 38
Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

Sahar Sheykhansari, Kristen Kozielski, Joachim Bill, Metin Sitti, Donato Gemmati, Paolo Zamboni, Ajay Vikram Singh

Cell Death & Disease 2018 9 3
The impact of brain iron accumulation on cognition: A systematic review

Holly Spence, Chris J. McNeil, Gordon D. Waiter, Efthimios M. C. Skoulakis

PLOS ONE 2020 15 10
Grey Matter Atrophy in Multiple Sclerosis: Clinical Interpretation Depends on Choice of Analysis Method

Veronica Popescu, Menno M. Schoonheim, Adriaan Versteeg, Nimisha Chaturvedi, Marianne Jonker, Renee Xavier de Menezes, Francisca Gallindo Garre, Bernard M. J. Uitdehaag, Frederik Barkhof, Hugo Vrenken, Tobias Derfuss

PLOS ONE 2016 11 1
Thalamic Injury and Cognition in Multiple Sclerosis

Moein Amin, Daniel Ontaneda

Frontiers in Neurology 2021 11
Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain

Jesper Hagemeier, Robert Zivadinov, Michael G. Dwyer, Paul Polak, Niels Bergsland, Bianca Weinstock-Guttman, Joshua Zalis, Andreas Deistung, Jürgen R. Reichenbach, Ferdinand Schweser

NeuroImage: Clinical 2018 18
Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals

Jesper Hagemeier, Murali Ramanathan, Ferdinand Schweser, Michael G. Dwyer, Fuchun Lin, Niels Bergsland, Bianca Weinstock-Guttman, Robert Zivadinov

NeuroImage: Clinical 2018 17
Thalamic Iron Differentiates Primary-Progressive and Relapsing-Remitting Multiple Sclerosis

A. Burgetova, P. Dusek, M. Vaneckova, D. Horakova, C. Langkammer, J. Krasensky, L. Sobisek, P. Matras, M. Masek, Z. Seidl

American Journal of Neuroradiology 2017 38 6
Cognitive Implications of Deep Gray Matter Iron in Multiple Sclerosis

E. Fujiwara, J.A. Kmech, D. Cobzas, H. Sun, P. Seres, G. Blevins, A.H. Wilman

American Journal of Neuroradiology 2017 38 5
Increased mean R2* in the deep gray matter of multiple sclerosis patients: Have we been measuring atrophy?

Enedino Hernández‐Torres, Vanessa Wiggermann, Lindsay Machan, A. Dessa Sadovnick, David K.B. Li, Anthony Traboulsee, Simon Hametner, Alexander Rauscher

Journal of Magnetic Resonance Imaging 2019 50 1
Early and Degressive Putamen Atrophy in Multiple Sclerosis

Julia Krämer, Sven Meuth, Jan-Gerd Tenberge, Patrick Schiffler, Heinz Wiendl, Michael Deppe

International Journal of Molecular Sciences 2015 16 10
Predictive value of different conventional and non-conventional MRI-parameters for specific domains of cognitive function in multiple sclerosis

Daniela Pinter, Michael Khalil, Alexander Pichler, Christian Langkammer, Stefan Ropele, Peter B. Marschik, Siegrid Fuchs, Franz Fazekas, Christian Enzinger

NeuroImage: Clinical 2015 7
Tea Consumption and Cognitive Impairment: A Cross-Sectional Study among Chinese Elderly

Wei Shen, Yuanyuan Xiao, Xuhua Ying, Songtao Li, Yujia Zhai, Xiaopeng Shang, Fudong Li, Xiyi Wang, Fan He, Junfen Lin, C. Mary Schooling

PLOS ONE 2015 10 9
White Matter Tract Injury is Associated with Deep Gray Matter Iron Deposition in Multiple Sclerosis

Niels Bergsland, Eleonora Tavazzi, Maria Marcella Laganà, Francesca Baglio, Pietro Cecconi, Stefano Viotti, Robert Zivadinov, Giuseppe Baselli, Marco Rovaris

Journal of Neuroimaging 2017 27 1
The Role of Advanced Magnetic Resonance Imaging Techniques in Multiple Sclerosis Clinical Trials

Kedar R. Mahajan, Daniel Ontaneda

Neurotherapeutics 2017 14 4
Thalamic white matter in multiple sclerosis: A combined diffusion‐tensor imaging and quantitative susceptibility mapping study

Niels Bergsland, Ferdinand Schweser, Michael G. Dwyer, Bianca Weinstock‐Guttman, Ralph H. B. Benedict, Robert Zivadinov

Human Brain Mapping 2018 39 10
Gray Matter Correlates of Cognitive Performance Differ between Relapsing-Remitting and Primary-Progressive Multiple Sclerosis

Laura E. Jonkman, Diana M. Rosenthal, Maria Pia Sormani, Laura Miles, Joseph Herbert, Robert I. Grossman, Matilde Inglese, Orhan Aktas

PLOS ONE 2015 10 10
Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention

Shaina L. Rosenblum, Daniel J. Kosman

Frontiers in Neurology 2022 13
Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes

Tanuja Chitnis, Jo Vandercappellen, Miriam King, Giampaolo Brichetto

Neurology and Therapy 2022 11 3
The Blood Concentration of Metallic Nanoparticles Is Related to Cognitive Performance in People with Multiple Sclerosis: An Exploratory Analysis

Marcela de Oliveira, Felipe Balistieri Santinelli, Paulo Noronha Lisboa-Filho, Fabio Augusto Barbieri

Biomedicines 2023 11 7
Causes, effects and connectivity changes in MS-related cognitive decline

Carolina de Medeiros Rimkus, Martijn D. Steenwijk, Frederik Barkhof

Dementia & Neuropsychologia 2016 10 1
Subcortical gray matter atrophy is associated with cognitive deficit in multiple sclerosis but not in systemic lupus erythematosus patients

A Kalinowska-Łyszczarz, M A Pawlak, A Pietrzak, K Pawlak-Buś, P Leszczyński, M Puszczewicz, D Majewski, W Paprzycki, W Kozubski, S Michalak

Lupus 2018 27 4
Localised Grey Matter Atrophy in Multiple Sclerosis and Clinically Isolated Syndrome—A Coordinate-Based Meta-Analysis, Meta-Analysis of Networks, and Meta-Regression of Voxel-Based Morphometry Studies

Sonika Singh, Christopher R. Tench, Radu Tanasescu, Cris S. Constantinescu

Brain Sciences 2020 10 11
Regional high iron deposition on quantitative susceptibility mapping correlates with cognitive decline in type 2 diabetes mellitus

Rui Hu, Bingbing Gao, Shiyun Tian, Yangyingqiu Liu, Yuhan Jiang, Wanyao Li, Yuan Li, Qingwei Song, Weiwei Wang, Yanwei Miao

Frontiers in Neuroscience 2023 17
Magnetic resonance imaging detection of deep gray matter iron deposition in multiple sclerosis: A systematic review

Amy D. De Lury, Joseph A. Bisulca, Jimmy S. Lee, Muhammad D. Altaf, Patricia K. Coyle, Tim Q. Duong

Journal of the Neurological Sciences 2023 453
Magnetotactic bacteria from the human gut microbiome associated with orientation and navigation regions of the brain

Rozalyn A. Simon, Purnika Damindi Ranasinghe, Nawroz Barazanji, Malin Bergman Jungeström, Jie Xu, Olga Bednarska, Lena Serrander, Maria Engström, Dennis A. Bazylinski, Åsa V. Keita, Susanna Walter

Journal of Oceanology and Limnology 2021 39 6
Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis

Di Ding, Anddre Osmar Valdivia, Sanjoy K. Bhattacharya

Metabolic Brain Disease 2020 35 2
Quantitative Susceptibility Mapping of the Thalamus: Relationships with Thalamic Volume, Total Gray Matter Volume, and T2 Lesion Burden

G.C. Chiang, J. Hu, E. Morris, Y. Wang, S.A. Gauthier

American Journal of Neuroradiology 2018 39 3
Should We Consider Neurodegeneration by Itself or in a Triangulation with Neuroinflammation and Demyelination? The Example of Multiple Sclerosis and Beyond

Océane Perdaens, Vincent van Pesch

International Journal of Molecular Sciences 2024 25 23
Brain Iron Deposition Alterations in Type 2 Diabetes Mellitus Patients With Mild Cognitive Impairment Based on Quantitative Susceptibility Mapping

Qiuyue Zhao, Subinuer Maimaitiaili, Yan Bi, Ming Li, Xin Li, Qian Li, Xinyi Shen, Min Wu, Linqing Fu, Zhengyang Zhu, Xin Zhang, Jiu Chen, Anning Hu, Zhou Zhang, Wen Zhang, Bing Zhang

Journal of Diabetes 2025 17 1
Cerebral iron accumulation in multiple sclerosis: Pathophysiology and therapeutic implications

Geir Bjørklund, David R. Wallace, Tony Hangan, Monica Butnariu, Leonard Gurgas, Massimiliano Peana

Autoimmunity Reviews 2025 24 4
Drug Discovery for Schizophrenia

S. Okafor

2024
Love in the Time of COVID: Psychiatric Outcomes Related to Oxytocin and the “Endocrine Organ”

Adonis Sfera, Sabine Hazan, Jacob Anton, Ioana Ciuperca, Carolina Klein, Karina G. Thomas

OBM Neurobiology 2025 09 02

PreviousNext

In this issue

American Journal of Neuroradiology

Vol. 36, Issue 1

1 Jan 2015

Table of Contents
Index by author
Complete Issue (PDF)

Download PDF

Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

Message Subject (Your Name) has sent you a message from American Journal of Neuroradiology

Message Body (Your Name) thought you would like to see the American Journal of Neuroradiology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Cite this article

C.M. Modica, R. Zivadinov, M.G. Dwyer, N. Bergsland, A.R. Weeks, R.H.B. Benedict

Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

American Journal of Neuroradiology Jan 2015, 36 (1) 57-62; DOI: 10.3174/ajnr.A3998

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

0 Responses

Respond to this article

Bookmark this article

User Name *

Password *

Remember my user name & password.

Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

C.M. Modica, R. Zivadinov, M.G. Dwyer, N. Bergsland, A.R. Weeks, R.H.B. Benedict

American Journal of Neuroradiology Jan 2015, 36 (1) 57-62; DOI: 10.3174/ajnr.A3998

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Purchase

Jump to section

Article
Figures & Data
Info & Metrics
Responses
References
PDF

No related articles found.

PubMed
Google Scholar

Cited By...

Gray Matter alterations in MS and CIS: a Coordinate based Meta-analysis and regression
Quantitative Susceptibility Mapping of the Thalamus: Relationships with Thalamic Volume, Total Gray Matter Volume, and T2 Lesion Burden
Thalamic Iron Differentiates Primary-Progressive and Relapsing-Remitting Multiple Sclerosis
Cognitive Implications of Deep Gray Matter Iron in Multiple Sclerosis

Crossref (34)
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping Imaging

Yeonsil Moon, Seol-Heui Han, Won-Jin Moon

Journal of Alzheimer's Disease 2016 51 3
Iron chelation in the treatment of neurodegenerative diseases

Petr Dusek, Susanne A. Schneider, Jan Aaseth

Journal of Trace Elements in Medicine and Biology 2016 38
Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

Sahar Sheykhansari, Kristen Kozielski, Joachim Bill, Metin Sitti, Donato Gemmati, Paolo Zamboni, Ajay Vikram Singh

Cell Death & Disease 2018 9 3
The impact of brain iron accumulation on cognition: A systematic review

Holly Spence, Chris J. McNeil, Gordon D. Waiter, Efthimios M. C. Skoulakis

PLOS ONE 2020 15 10
Grey Matter Atrophy in Multiple Sclerosis: Clinical Interpretation Depends on Choice of Analysis Method

Veronica Popescu, Menno M. Schoonheim, Adriaan Versteeg, Nimisha Chaturvedi, Marianne Jonker, Renee Xavier de Menezes, Francisca Gallindo Garre, Bernard M. J. Uitdehaag, Frederik Barkhof, Hugo Vrenken, Tobias Derfuss

PLOS ONE 2016 11 1
Thalamic Injury and Cognition in Multiple Sclerosis

Moein Amin, Daniel Ontaneda

Frontiers in Neurology 2021 11
Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain

Jesper Hagemeier, Robert Zivadinov, Michael G. Dwyer, Paul Polak, Niels Bergsland, Bianca Weinstock-Guttman, Joshua Zalis, Andreas Deistung, Jürgen R. Reichenbach, Ferdinand Schweser

NeuroImage: Clinical 2018 18
Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals

Jesper Hagemeier, Murali Ramanathan, Ferdinand Schweser, Michael G. Dwyer, Fuchun Lin, Niels Bergsland, Bianca Weinstock-Guttman, Robert Zivadinov

NeuroImage: Clinical 2018 17
Thalamic Iron Differentiates Primary-Progressive and Relapsing-Remitting Multiple Sclerosis

A. Burgetova, P. Dusek, M. Vaneckova, D. Horakova, C. Langkammer, J. Krasensky, L. Sobisek, P. Matras, M. Masek, Z. Seidl

American Journal of Neuroradiology 2017 38 6
Cognitive Implications of Deep Gray Matter Iron in Multiple Sclerosis

E. Fujiwara, J.A. Kmech, D. Cobzas, H. Sun, P. Seres, G. Blevins, A.H. Wilman

American Journal of Neuroradiology 2017 38 5

Main menu

User menu

Search

American Journal of Neuroradiology

Iron and Volume in the Deep Gray Matter: Association with Cognitive Impairment in Multiple Sclerosis

Article Information

Author Information

Altmetrics

Cited By...

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Similar Articles

Indexed Content

Cases

Special Collections

Resources

Multimedia

About Us

American Society of Neuroradiology