Macro- and Microstructural Changes in Patients with Spinocerebellar Ataxia Type 6: Assessment of Phylogenetic Subdivisions of the Cerebellum and the Brain Stem

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Fig 1.
Infratentorial parcellation map. The cerebellum is divided into 12 subdivisions, and the brain stem, into 6 subdivisions.
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Fig 2.
Comparison of the data in each cerebellar subdivision between patients with SCA6 and controls. Independent samples t tests were performed with false discovery rate correction applied to P < .05. Ant. indicates anterior; post., posterior.
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Fig 3.
Percentage changes of fractional volume and MD in patients with SCA6 compared with controls (changes of >25% are shown). The degrees of percentage change are presented in different colors. The changes of FA are <25% and are not shown.

Correlations between the data and ICARS scores in the infratentorial brain^{^a}

SCA6	Fractional Volume (%)	MD (× 10⁻³mm²/s)	FA
Left anterior lobe	Static^{^b} (r = −0.82), Dysarthria^{^c} (r = −0.73)	NS	NS
Right anterior lobe	NS	NS	NS
Left posterior lobe	NS	Total^{^d} (r = 0.87), Dysarthria^{^c} (r = 0.77)	Limb^{^c} (r = −0.73)
Right posterior lobe	Static^{^c} (r = −0.66)	Total^{^d} (r = 0.83), Limb^{^c} (r = 0.73)	NS
Anterior vermis	NS	NS	NS
Posterior vermis	NS	NS	Limb^{^c} (r = −0.73)
Left deep structure	Total^{^c} (r = −0.75)	NS	NS
Right deep structure	Total^{^d} (r = −0.87), Limb^{^c} (r = −0.74)	NS	NS
Left tonsil	NS	NS	NS
Right tonsil	NS	Total^{^c} (r = 0.73), Static^{^d} (r = 0.82), Dysarthria^{^d} (r = 0.85)	NS
Left flocculonodular lobe	Static^{^c} (r = −0.74)	NS	NS
Right flocculonodular lobe	Total^{^d} (r = −0.77), Static^{^d} (r = −0.92), Dysarthria^{^d} (r = −0.80)	NS	NS
Midbrain	Total^{^c} (r = −0.77)	NS	NS
Pons	NS	NS	NS
Medulla	NS	NS	NS
SCP	Static^{^c} (r = −0.71)	NS	NS
MCP	NS	NS	NS
ICP	NS	NS	NS

Note:—NS indicates not significant.
↵a ICARS scores that significantly correlated with the data are shown. “Static,” “Dysarthria,” and “Limb” are subscores of ICARS. A Spearman correlation analysis with false discovery rate correction applied to P < .05 was performed. A multiple linear regression analysis excluding age effects was performed in the subdivisions in which the data significantly correlated with age.
↵b P < .001.
↵c P < .05.
↵d P < .01.