Article Figures & Data
Figures
- Fig 1.
A–C, Scatterplots showing different rates of change of rCBV for PS with inset sketches showing how they correspond to different stages of angiogenesis for glioma grades II, III, and IV, respectively. D, A combined scatterplot for all glioma grades showing different rates of change of rCBV for PS. Inset sketches adapted with permission from Nat Rev Cancer 2003;3:401–10.
- Fig 2.
Bar chart showing the ratio of rCBV to PS (rCBV/PS).
- Fig 3.
World Health Organization grade III glioma. A, Representative postcontrast T1-weighted axial MR image shows a large solid tumor with heterogeneous areas of enhancement. Corresponding CT perfusion CBV (B) and PS (C) maps show marked heterogeneity in different segments of the tumor (eg, ROI 5 shows markedly increased CBV) but not very high PS; and on the contrary, ROI 3 shows a marked increase of PS, but not very high CBV. This case is an example of a markedly heterogeneous tumor (as seen on postcontrast MR images), and this markedly heterogeneous imaging appearance could be due to the underlying complexity of angiogenesis. Some of this heterogeneity could be explained by a very complex interplay of CBV and PS, and these two parameters probably do not increase in perfect tandem.
Tables
Group rCBV No. Corr P Value Grade II 13 0.710 .006 Grade III 18 0.822 <.001 Grade IV 45 0.467 .001 Comparisons II vs III, P = .499 II vs IV, P = .279 III vs IV, P = .029 Note:—Corr indicates correlation.
Group Comparison rCBV P Value for Intercept P Value for Slope Grade II vs III .565 .423 Grade II vs IV .004 .095 Grade III vs IV <.001 .001 Group No. rCBV/PS Mean SD Grade II 13 3.26 0.98 Grade III 18 2.46 0.88 Grade IV 45 1.41 0.53
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