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Research ArticleSpine Imaging and Spine Image-Guided Interventions

Bone-Subtracted Spinal CT Angiography Using Nonrigid Registration for Better Visualization of Arterial Feeders in Spinal Arteriovenous Fistulas

T. Nishii, A.K. Kono, M. Nishio, N. Negi, A. Fujita, E. Kohmura and K. Sugimura
American Journal of Neuroradiology December 2015, 36 (12) 2400-2406; DOI: https://doi.org/10.3174/ajnr.A4435
T. Nishii
aFrom the Departments of Radiology (T.N., A.K.K., M.N., K.S.)
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A.K. Kono
aFrom the Departments of Radiology (T.N., A.K.K., M.N., K.S.)
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M. Nishio
aFrom the Departments of Radiology (T.N., A.K.K., M.N., K.S.)
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N. Negi
cDivision of Radiology (N.N.), Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan.
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A. Fujita
bNeurosurgery (A.F., E.K.), Kobe University Graduate School of Medicine, Kobe, Japan
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E. Kohmura
bNeurosurgery (A.F., E.K.), Kobe University Graduate School of Medicine, Kobe, Japan
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K. Sugimura
aFrom the Departments of Radiology (T.N., A.K.K., M.N., K.S.)
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  • Fig 1.
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    Fig 1.

    A, An original image. B, Image generated by rotating A and deforming the tip of the hat (dashed circle). C, An ordinary subtracted image that was obtained by subtracting image B from A. This step causes misregistration in which a large amount of the white or black area is seen. D and E, Subtracted images that were obtained by subtracting image A from the warped image of image B created by rigid and nonrigid registration, respectively. D, Deformation of the hat remains and leads to misregistration around the tip of the hat. E, Perfect subtraction by restoring the rotation and deformation.

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    Fig 2.

    First, warped images of the late arterial phase were obtained by using nonrigid registration (SyN–cross-correlation) adjusted to the arterial phase images. The subtracted spinal CTA by using nonrigid registration was then obtained by subtracting warped images that were multiplied by 1.1 from the arterial phase images. R-CTA and conventional spinal CTA were analyzed with digital subtraction angiography results as a reference standard, and the difference in diagnostic performance was assessed.

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    Fig 4.

    Images of an illustrative case of a 53-year-old man (case 5). Spinal digital subtraction angiography of the right ninth ICA (A) shows a feeder and enlarged vein. C-CTA image (B) and R-CTA (C) at the T9 level can detect the feeder (black arrowhead) from the right ninth ICA. In R-CTA with thin-slab maximum-intensity-projection images, assessing the feeder and continuity is easier than with C-CTA. The window level and width of R-CTA are set to 120 and 240, respectively.

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    Fig 5.

    Images of an illustrative case of a 57-year-old man (case 10). Spinal digital subtraction angiography of the right second lumbar artery (A) shows a feeder and enlarged vein. In the C-CTA image (B), the right T12 was misread as the feeder (black arrowhead). Furthermore, in C-CTA at the L2 level, the true feeder from the right second lumbar artery was difficult to differentiate from the blooming artifacts of the neighboring bone. However, in R-CTA (C), the true feeder from the right second lumbar artery was easily detected (white arrow). The window level and width of R-CTA are set to 120 and 240, respectively.

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    Fig 3.

    In an ordinary subtraction image (left), determining the level of the vertebra is difficult because the background is totally equaled. However, in a weighted subtraction image (right), the bone is displayed as a darker structure than background attenuation.

Tables

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    Table 1:

    Subject characteristics and the level of feeders as shown by spinal digital subtraction angiography results

    CaseAge (yr)SexClinical ManifestationFeederType
    Side and LevelOrigin
    160FParaplegia––No AVF
    283MClaudicationLt. L1LAD
    371MParaplegiaRt. L2LAD
    478MParaplegiaRt. T7, Lt. T11ICAD
    553MParaplegiaRt. T9ICAD
    674MParaparesis––No AVF
    749MParaplegiaLt. T6ICAPM
    866MParaplegiaLt. T6, Lt. T7ICAD
    939MParaplegiaLt.T5, Lt. T6ICAD
    1057MParaplegiaRt. L2LAD
    1167FParaplegiaLt. L3LAPM
    1280MParaplegiaRt. T4, Rt. T5ICAD
    1345MParaplegiaRt. T4ICAD
    1471MParaplegiaLt. T3, Rt. T5ICAPM
    1587MParaplegiaLt. T4ICAD
    • Note:—D indicates dural AVF; LA, lumber artery; PM, perimedullary AVF; –, data not available; ICA, intercostal artery; T, thoracic spine; L, lumbar spine; Rt., right; Lt, left.

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    Table 2:

    Differences in diagnostic performance of C-CTA and R-CTA

    VariablesC-CTAR-CTAORaP Values
    Subject-based analysis
        Feeder detection accuracy (%)
            Observer 147 (7/15)80 (12/15).025b
            Observer 240 (6/15)73 (11/15).025b
        Time required for diagnosis (sec)
            Observer 197.1 ± 37.445.1 ± 23.6.002b
            Observer 289.5 ± 60.045.6 ± 24.1.020b
    Intervertebral foramen–based analysis
        Sensitivity (%)c44.4 (22.2–66.7)72.2 (50.0–94.4)3.26 (0.82–13.0).095
        Specificity (%)c98.1 (97.8–99.5)99.5 (98.7–100)3.55 (0.87–14.5).077
        Accuracy (%)c95.6 (93.8–97.2)98.2 (96.9–99.2)2.49 (1.04–6.00).041b
    • ↵a ORs of R-CTA against C-CTA are shown.

    • ↵b Significant.

    • ↵c 95% Confidence intervals are shown.

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American Journal of Neuroradiology: 36 (12)
American Journal of Neuroradiology
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1 Dec 2015
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Cite this article
T. Nishii, A.K. Kono, M. Nishio, N. Negi, A. Fujita, E. Kohmura, K. Sugimura
Bone-Subtracted Spinal CT Angiography Using Nonrigid Registration for Better Visualization of Arterial Feeders in Spinal Arteriovenous Fistulas
American Journal of Neuroradiology Dec 2015, 36 (12) 2400-2406; DOI: 10.3174/ajnr.A4435

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Bone-Subtracted Spinal CT Angiography Using Nonrigid Registration for Better Visualization of Arterial Feeders in Spinal Arteriovenous Fistulas
T. Nishii, A.K. Kono, M. Nishio, N. Negi, A. Fujita, E. Kohmura, K. Sugimura
American Journal of Neuroradiology Dec 2015, 36 (12) 2400-2406; DOI: 10.3174/ajnr.A4435
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