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Two blinded neuroradiologists retrospectively graded 23 prespecified imaging abnormalities in the craniofacial region on CT examinations from 42 patients with pathology-proven acute invasive fungal rhinosinusitis and 42 control patients. A 7-variable model (periantral fat, bone dehiscence, orbital invasion, septal ulceration, pterygopalatine fossa, nasolacrimal duct, and lacrimal sac) was synthesized on the basis of multivariate analysis. The presence of abnormality involving a single variable in the model had an 87% positive predictive value, 95% negative predictive value, 95% sensitivity, and 86% specificity.

The authors evaluated 62 consecutive patients with ischemic stroke with proven vessel occlusion with MRI before and within 24 hours of treatment and defined a hypoperfusion intensity ratio (volume with severe/mild hypoperfusion [time-to-maximum ≥ 8 seconds / time-to-maximum ≥ 2 seconds]). Patients with extensive hyperintense vessels on FLAIR (>4 sections) had higher NIHSS scores, larger baseline lesion volumes, higher rates of perfusion-diffusion mismatch, and more severe hypoperfusion intensity ratio.