Article Figures & Data
Figures
- Fig 1.
TBSS significant differences in diffusion measurements between patients with SCA7 and healthy controls. A, Fractional anisotropy. B, Mean diffusivity. Warm and cold colors indicate an increase and decrease in these measures in patients with SCA7, respectively.
- Fig 2.
White matter regions where MD correlates with the SARA score in the SCA7 group. Warm colors indicate significant correlations between MD values and SARA scores.
Tables
ID Sex Age (yr) Years from Onset MMSE MoCA SARA P01 F 21 1 26 NC 4 P02 M 20 1 29 NC 4 P03 F 68 1 24 NC 6 P04 F 18 4 27 NC 7 P05 F 35 6 26 NC 8.5 P06 F 44 6 26 16 9 P07 F 64 13 28 12 9.5 P08 M 44 4 24 18 11 P09 F 22 2 26 NC 11 P10 M 52 7 26 16 12 P11 F 45 7 26 21 12 P12 M 23 3 24 27 12.5 P13 M 47 6 26 14 13 P14 M 25 4 26 13 14 P15 M 64 10 26 15 14.5 P16 M 38 13 27 18 14.5 P17 F 43 21 26 NC 15 P18 M 35 14 26 9 16 P19 M 60 6 26 13 16 P20 M 30 6 25 12 16 P21 M 34 10 28 NC 17 P22 M 30 5 26 NC 17 P23 F 32 6 27 NC 19 P24 M 18 8 26 16 19.5 P25 F 40 13 25 NC 23 P26 M 54 6 25 NC 24 P27 M 61 7 22 NC 25 P28 M 29 7 21 17 25 P29 F 40 21 22 18 27 P30 F 39 23 25 18 27 P31 F 42 17 23 15 29.5 P32 M 19 7 22 10 29.5 P33 F 51 8 26 18 30 Note:—MMSE indicates Mini-Mental State Examination; MoCA, Montreal Cognitive Assessment; NC, not completed; ID, identification.
- Table 2:
Significant group differences in fractional anisotropy between patients with SCA7 and healthy controlsa
Anatomic Region Voxels T-Value X Y Z Right superior cerebellar peduncle 1797 18.9 7 −47 −28 Left corticospinal tract 1009 11 −13 −56 −28 Left anterior corona radiata 733 6.86 −26 31 11 Body of corpus callosum 327 4.04 −6 13 22 Right corticospinal tract 262 11 13 −50 −43 Left uncinate fasciculus 253 6.27 −21 18 −12 Left superior longitudinal fasciculus 180 5.08 −10 27 49 Left inferior longitudinal fasciculus 177 5.75 −40 −47 −13 Right superior longitudinal fasciculus 162 4.53 36 −13 34 Left anterior limb of the internal capsule 134 5.07 −20 17 5 Left cingulate WM 131 6.36 −6 3 34 Left inferior fronto-occipital fasciculus 121 4.89 −16 35 33 Left superior longitudinal fasciculus 114 4.75 −44 −41 13 Right superior longitudinal fasciculus 112 4.22 51 −7 23 ↵a Coordinates are in millimeters in Montreal Neurological Institute space. Labels are from the Johns Hopkins University white matter atlas.
- Table 3:
Significant group differences in mean diffusivity between patients with SCA7 and healthy controlsa
Anatomic Region Voxels T-Value X Y Z Right middle cerebellar peduncle 2712 11.1 26 −51 −37 Left middle cerebellar peduncle 2047 12.6 −26 −48 −38 Left anterior thalamic radiation 911 5.12 −3 −11 11 Right inferior fronto-occipital fasciculus 855 5.19 19 −83 16 Left inferior longitudinal fasciculus 628 4.21 −14 −81 2 Left posterior thalamic radiation 350 3.23 −35 −44 8 Right inferior longitudinal fasciculus 182 4.39 37 −74 2 Right cingulate WM 141 3.59 27 −45 −2 Right posterior corona radiata 112 5.22 29 −34 19 Right anterior thalamic radiation 108 4.16 1 −20 −10 Splenium of corpus callosum 104 4.91 19 −50 22 Left cingulate WM 101 3.58 −28 −50 −1 Left inferior longitudinal fasciculus 100 3.38 −17 −77 15 ↵a Coordinates are in millimeters in Montreal Neurological Institute space. Labels are from the Johns Hopkins University white matter atlas.
- Table 4:
White matter regions showing significant correlation between MD and the SARA score in the SCA7 groupa
Anatomic Region Voxels T-Value X Y Z Right inferior longitudinal fasciculus 6428 6.74 40 −74 6 Right superior cerebellar peduncle 1420 9.16 7 −43 −23 Left cerebellum anterior lobule 1014 7.03 −14 −53 −28 Left inferior fronto-occipital fasciculus 684 7.89 −19 −86 −9 Right anterior thalamic radiation 239 5.92 14 −60 49 Right superior longitudinal fasciculus 158 5.54 44 −34 34 Left anterior thalamic radiation 148 10.1 −3 −9 12 ↵a Coordinates are in millimeters in Montreal Neurological Institute space. Labels are from the Johns Hopkins University white matter atlas.
