Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleAdult Brain
Open Access

Vascular Dysfunction in Leukoaraiosis

K. Sam, A.P. Crawley, J. Poublanc, J. Conklin, O. Sobczyk, D.M. Mandell, J. Duffin, L. Venkatraghavan, J.A. Fisher, S.E. Black and D.J. Mikulis
American Journal of Neuroradiology December 2016, 37 (12) 2258-2264; DOI: https://doi.org/10.3174/ajnr.A4888
K. Sam
aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Sam
A.P. Crawley
bMedical Imaging (A.P.C., D.J.M.), University of Toronto, Toronto, Ontario, Canada
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.P. Crawley
J. Poublanc
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Poublanc
J. Conklin
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Conklin
O. Sobczyk
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for O. Sobczyk
D.M. Mandell
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.M. Mandell
J. Duffin
aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Duffin
L. Venkatraghavan
dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.A. Fisher
aFrom the Departments of Physiology (K.S., J.D., J.A.F.)
dDepartment of Anesthesiology (J.D., L.V., J.A.F.), University Health Network and The University of Toronto, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.A. Fisher
S.E. Black
eL.C. Campbell Cognitive Neurology Research Unit (S.E.B.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.E. Black
D.J. Mikulis
bMedical Imaging (A.P.C., D.J.M.), University of Toronto, Toronto, Ontario, Canada
cDivision of Neuroradiology (K.S., A.P.C., J.P., J.C., O.S., D.M.M., D.J.M.), Joint Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.J. Mikulis
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading
Submit a Response to This Article
Compose eLetter

More information about text formats

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g. higgs-boson@gmail.com
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 37 (12)
American Journal of Neuroradiology
Vol. 37, Issue 12
1 Dec 2016
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Vascular Dysfunction in Leukoaraiosis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
K. Sam, A.P. Crawley, J. Poublanc, J. Conklin, O. Sobczyk, D.M. Mandell, J. Duffin, L. Venkatraghavan, J.A. Fisher, S.E. Black, D.J. Mikulis
Vascular Dysfunction in Leukoaraiosis
American Journal of Neuroradiology Dec 2016, 37 (12) 2258-2264; DOI: 10.3174/ajnr.A4888

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Vascular Dysfunction in Leukoaraiosis
K. Sam, A.P. Crawley, J. Poublanc, J. Conklin, O. Sobczyk, D.M. Mandell, J. Duffin, L. Venkatraghavan, J.A. Fisher, S.E. Black, D.J. Mikulis
American Journal of Neuroradiology Dec 2016, 37 (12) 2258-2264; DOI: 10.3174/ajnr.A4888
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • The Relationship between Cerebrovascular Reactivity and Cerebral Oxygenation during Hemodialysis
  • Intracranial hemodynamic relationships in patients with cerebral small vessel disease
  • White Matter Lesion Penumbra Shows Abnormalities on Structural and Physiologic MRIs in the Coronary Artery Risk Development in Young Adults Cohort
  • Intracranial functional haemodynamic relationships in patients with cerebral small vessel disease
  • Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke
  • Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms
  • Crossref (37)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Understanding the role of the perivascular space in cerebral small vessel disease
    Rosalind Brown, Helene Benveniste, Sandra E Black, Serge Charpak, Martin Dichgans, Anne Joutel, Maiken Nedergaard, Kenneth J Smith, Berislav V Zlokovic, Joanna M Wardlaw
    Cardiovascular Research 2018 114 11
  • Advances in Understanding the Pathophysiology of Lacunar Stroke
    Robert W. Regenhardt, Alvin S. Das, Eng H. Lo, Louis R. Caplan
    JAMA Neurology 2018 75 10
  • Intracranial hemodynamic relationships in patients with cerebral small vessel disease
    Gordon W. Blair, Michael J. Thrippleton, Yulu Shi, Iona Hamilton, Michael Stringer, Francesca Chappell, David Alexander Dickie, Peter Andrews, Ian Marshall, Fergus N. Doubal, Joanna M. Wardlaw
    Neurology 2020 94 21
  • Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms
    Anne Joutel, Hugues Chabriat
    Clinical Science 2017 131 8
  • Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients
    Qing Lin, Wen-Qing Huang, Qi-Lin Ma, Cong-Xia Lu, Sui-Jun Tong, Jin-Hu Ye, Hui-Nuan Lin, Long Gu, Ke-Hui Yi, Liang-Liang Cai, Chi-Meng Tzeng
    Medicine 2017 96 39
  • Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations
    Robert W. Regenhardt, Alvin S. Das, Ryo Ohtomo, Eng H. Lo, Cenk Ayata, Mahmut Edip Gurol
    Journal of Stroke and Cerebrovascular Diseases 2019 28 8
  • Leukoaraiosis severity and outcomes after mechanical thrombectomy with stent-retriever devices in acute ischemic stroke
    Yongtao Guo, Wenjie Zi, Yue Wan, Shuai Zhang, Bo Sun, Xianjin Shang, Shun Li, Yongjie Bai, Zibao Li, Dequan Zheng, Xinfeng Liu
    Journal of NeuroInterventional Surgery 2019 11 2
  • Emerging role of white matter lesions in cerebrovascular disease
    Aarushi Rastogi, Robert Weissert, Sonu Menachem Maimonides Bhaskar
    European Journal of Neuroscience 2021 54 4
  • Role of White Matter Hyperintensities and Related Risk Factors in Vascular Cognitive Impairment: A Review
    Yiyi Chen, Xing Wang, Ling Guan, Yilong Wang
    Biomolecules 2021 11 8
  • Cerebrovascular Reactivity: Purpose, Optimizing Methods, and Limitations to Interpretation – A Personal 20-Year Odyssey of (Re)searching
    Joseph A. Fisher, David J. Mikulis
    Frontiers in Physiology 2021 12

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • ML for Glioma Molecular Subtype Prediction
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire