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Research ArticleAdult Brain
Open Access

Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T

E.J. Meyer, I.I. Kirov, A. Tal, M.S. Davitz, J.S. Babb, M. Lazar, D. Malaspina and O. Gonen
American Journal of Neuroradiology December 2016, 37 (12) 2273-2279; DOI: https://doi.org/10.3174/ajnr.A4886
E.J. Meyer
aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
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  • ORCID record for E.J. Meyer
I.I. Kirov
aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
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A. Tal
cDepartment of Chemical Physics (A.T.), Weizmann Institute of Science, Rehovot, Israel.
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M.S. Davitz
aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
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J.S. Babb
aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
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M. Lazar
aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
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D. Malaspina
bDepartment of Psychiatry (D.M.), Institute for Social and Psychiatric Initiatives, New York University School of Medicine, New York, New York
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O. Gonen
aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
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Article Information

vol. 37 no. 12 2273-2279
DOI 
https://doi.org/10.3174/ajnr.A4886
PubMed 
27444940

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received March 31, 2016
  • Accepted after revision June 3, 2016
  • Published online December 15, 2016.

Copyright & Usage 
© 2016 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. E.J. Meyera,
  2. I.I. Kirova,
  3. A. Talc,
  4. M.S. Davitza,
  5. J.S. Babba,
  6. M. Lazara,
  7. D. Malaspinab and
  8. O. Gonena
  1. aFrom the Department of Radiology (E.J.M., I.I.K., M.S.D., J.S.B., M.L., O.G.), Center for Advanced Imaging Innovation and Research, Bernard and Irene Schwartz Center for Biomedical Imaging
  2. bDepartment of Psychiatry (D.M.), Institute for Social and Psychiatric Initiatives, New York University School of Medicine, New York, New York
  3. cDepartment of Chemical Physics (A.T.), Weizmann Institute of Science, Rehovot, Israel.
  1. Please address correspondence to Oded Gonen, PhD, Department of Radiology, New York University School of Medicine, 660 First Ave, 4th Floor, New York, NY 10016; e-mail: oded.gonen{at}med.nyu.edu
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Cite this article
E.J. Meyer, I.I. Kirov, A. Tal, M.S. Davitz, J.S. Babb, M. Lazar, D. Malaspina, O. Gonen
Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T
American Journal of Neuroradiology Dec 2016, 37 (12) 2273-2279; DOI: 10.3174/ajnr.A4886

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Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T
E.J. Meyer, I.I. Kirov, A. Tal, M.S. Davitz, J.S. Babb, M. Lazar, D. Malaspina, O. Gonen
American Journal of Neuroradiology Dec 2016, 37 (12) 2273-2279; DOI: 10.3174/ajnr.A4886
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Cited By...

  • Preliminary Findings Associate Hippocampal 1H-MR Spectroscopic Metabolite Concentrations with Psychotic and Manic Symptoms in Patients with Schizophrenia
  • Crossref (13)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis
    Matthijs G. Bossong, Mathilde Antoniades, Matilda Azis, Carly Samson, Beverley Quinn, Ilaria Bonoldi, Gemma Modinos, Jesus Perez, Oliver D. Howes, James M. Stone, Paul Allen, Philip McGuire
    JAMA Psychiatry 2019 76 2
  • Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis
    Thomas Samuel Whitehurst, Martin Osugo, Leigh Townsend, Ekaterina Shatalina, Robert Vava, Ellis Chika Onwordi, Oliver Howes
    Neuroscience & Biobehavioral Reviews 2020 119
  • The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group
    Brenda L Bartnik-Olson, Jeffry R Alger, Talin Babikian, Ashley D Harris, Barbara Holshouser, Ivan I Kirov, Andrew A Maudsley, Paul M Thompson, Emily L Dennis, David F Tate, Elisabeth A Wilde, Alexander Lin
    Brain Imaging and Behavior 2021 15 2
  • NMDA Receptor Model of Antipsychotic Drug-Induced Hypofrontality
    Marek Krzystanek, Artur Pałasz
    International Journal of Molecular Sciences 2019 20 6
  • Gut and oral microbiome modulate molecular and clinical markers of schizophrenia-related symptoms: A transdiagnostic, multilevel pilot study
    Jakleen J. Lee, Enrica Piras, Sabrina Tamburini, Kevin Bu, David S. Wallach, Brooke Remsen, Adam Cantor, Jennifer Kong, Deborah Goetz, Kevin W. Hoffman, Mharisi Bonner, Peter Joe, Bridget R. Mueller, Jessica Robinson-Papp, Eyal Lotan, Oded Gonen, Dolores Malaspina, Jose C. Clemente
    Psychiatry Research 2023 326
  • Study of the hippocampal internal architecture in temporal lobe epilepsy using 7 T and 3 T MRI
    Yiwei Zhang, Yuelei Lv, Hui You, Wanchen Dou, Bo Hou, Lin Shi, Zhentao Zuo, Weiyu Mao, Feng Feng
    Seizure 2019 71
  • MRI investigation of immune dysregulation in schizophrenia
    Shiral S. Gangadin, Lyliana G. Nasib, Iris E.C. Sommer, René C.W. Mandl
    Current Opinion in Psychiatry 2019 32 3
  • Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study
    Juan R. Bustillo, Joel Upston, Elizabeth Grace Mayer, Thomas Jones, Andrew A. Maudsley, Charles Gasparovic, Mauricio Tohen, Rhoshel Lenroot
    Neuropsychopharmacology 2020 45 11
  • An integrative study of the microbiome gut-brain-axis and hippocampal inflammation in psychosis: Persistent effects from mode of birth
    Peter Joe, Jose C. Clemente, Enrica Piras, David S. Wallach, Jessica Robinson-Papp, Emeka Boka, Brooke Remsen, Mharisi Bonner, David Kimhy, Deborah Goetz, Kevin Hoffman, Jakleen Lee, Eugene Ruby, Sarah Fendrich, Oded Gonen, Dolores Malaspina
    Schizophrenia Research 2022 247
  • Preliminary Findings Associate Hippocampal 1H-MR Spectroscopic Metabolite Concentrations with Psychotic and Manic Symptoms in Patients with Schizophrenia
    D. Malaspina, E. Lotan, H. Rusinek, S.A. Perez, J. Walsh-Messinger, T.M. Kranz, O. Gonen
    American Journal of Neuroradiology 2021 42 1

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