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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences

J. Ramalho, M. Ramalho, M. AlObaidy, R.H. Nunes, M. Castillo and R.C. Semelka
American Journal of Neuroradiology August 2016, 37 (8) 1427-1431; DOI: https://doi.org/10.3174/ajnr.A4757
J. Ramalho
aFrom the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
bDepartment of Neuroradiology (J.R.), Centro Hospitalar de Lisboa Central, Lisbon, Portugal
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M. Ramalho
aFrom the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
cDepartment of Radiology (M.R.), Hospital Garcia de Orta, Almada, Portugal
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M. AlObaidy
aFrom the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
dDepartment of Radiology (M.A.), King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
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R.H. Nunes
aFrom the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
eDivision of Neuroradiology (R.H.N.), Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.
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M. Castillo
aFrom the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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R.C. Semelka
aFrom the Department of Radiology (J.R., M.R., M.A., R.H.N., M.C., R.C.S.), University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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    Fig 1.

    Axial MR images in a 40-year-old male patient with a right frontal low-grade astrocytoma. Unenhanced axial T1-weighted spin-echo (A and C) and 3D MPRAGE MR images (B and D) of the first (A and B) and fifth (2 years later, C and D) gadolinium-enhanced MR imaging examinations at the level of the dentate nuclei of the cerebellum. The images show progressively increased T1 signal of the dentate nuclei (white arrows, C and D). Note that the qualitative analysis was slightly different between the 2 sequences.

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    Fig 2.

    Bland-Altman plots show the differences in average ROI measurements between the 2 readers for the dentate nucleus (A) and middle cerebellar peduncle (B).

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    Fig 3.

    Intraindividual linear graphic representation of the DN/MCP ratios, with error bars, for spin-echo and 3D MPRAGE sequences. Note the higher ratios with SE on both baseline and final examinations.

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    Fig 4.

    Intraindividual linear graphic representation demonstrating the correlation between qualitative and quantitative (DN/MCP ratio) evaluations of the increased T1 signal intensity within the dentate nucleus for SE and 3D MPRAGE sequences. Note the stronger correlation with MPRAGE (0.9) compared with SE (0.63). Values on the y-axis are represented on an ordinal scale with random vertical offset (jitter) to minimize overlapping.

Tables

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  • Patients' demographic and clinical characteristics

    Demographics
    Patients (number)18
    Sex12 Women
    Age (mean ± SD) (range) (yrs)52.56 ± 15.21 (17–76)
    eMRIs performed (mean ± SD) (range)4.78 ± 2.51 (2–10)
    Interval (MRIbaseline − MRIx) (mean ± SD) (range)933 ± 610.78 (96–1905 days)
    Diagnosis (number)
        Meningioma12
        Glioblastoma2
        Low-grade glioma1
        Oligodendroglioma1
        Chordoma1
        Spinal hemangioblastoma1
    • Note:—eMRI indicates enhanced MR imaging; yrs, years.

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American Journal of Neuroradiology: 37 (8)
American Journal of Neuroradiology
Vol. 37, Issue 8
1 Aug 2016
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Cite this article
J. Ramalho, M. Ramalho, M. AlObaidy, R.H. Nunes, M. Castillo, R.C. Semelka
T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences
American Journal of Neuroradiology Aug 2016, 37 (8) 1427-1431; DOI: 10.3174/ajnr.A4757

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T1 Signal-Intensity Increase in the Dentate Nucleus after Multiple Exposures to Gadodiamide: Intraindividual Comparison between 2 Commonly Used Sequences
J. Ramalho, M. Ramalho, M. AlObaidy, R.H. Nunes, M. Castillo, R.C. Semelka
American Journal of Neuroradiology Aug 2016, 37 (8) 1427-1431; DOI: 10.3174/ajnr.A4757
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