Dentate Update: Imaging Features of Entities That Affect the Dentate Nucleus

Illustration of the location of the dentate nucleus within the cerebellum. Used with permission of Mayo Foundation for Medical Education and Research, all rights reserved.

Hypertensive hemorrhage. A 55-year-old man who presented with a thalamic hemorrhage. Three selected images from 3D susceptibility-weighted imaging demonstrate microhemorrhages and hemosiderin deposition within the dentate nuclei (white arrows), brain stem, thalamus, and basal ganglia. The sentinel bleed is shown with black arrows. This distribution is characteristic of hypertensive microhemorrhages. The patient was being treated with multiple medications to control his hypertension, which remained elevated even during his hospitalization.

Metronidazole toxicity. A 74-year-old woman was treated for 6 weeks with metronidazole and developed dysarthria. T2 FLAIR images demonstrate T2 hyperintensity within the dentate nuclei (A, arrows), which resolved on MR imaging 1 month later (B).

Gadolinium deposition. A 13-year-old boy was diagnosed with a pilocytic astrocytoma and treated with chemotherapy, but no radiation. A, the first available pregadolinium T1WI without any abnormality in the dentate. B, A follow-up examination performed 10 years later now demonstrates T1 hyperintensity on TIWI within the dentate nuclei (arrows). The patient had undergone 37 gadolinium-enhanced examinations at this time point.

Neurodegeneration with brain iron accumulation. A 40-year-old woman with Woodhouse-Sakati syndrome found to have neurodegenerative iron accumulation. Marked hypointensity within the dentate on T2WI (A, white arrows) and 3D SWI (B, black arrows) is consistent with iron deposition.

Fahr disease. A–D, CT and T2* gradient recalled-echo images from a 49-year-old patient with Fahr disease demonstrate dense calcification of the dentate nuclei and basal ganglia. E and F, Dense calcification within the dentate nuclei and basal ganglia is also well-demonstrated on susceptibility-weighted imaging, in this case from a 68-year-old affected woman.