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Fifteen male freedivers underwent repetitive 3T pseudocontinuous ASL and ³¹P-/¹H-MR spectroscopy before, during, and after a 5-minute breath-hold (split into early and late phases) and gave temporally matching venous blood gas samples. The spatial coefficient of variation of CBF (by arterial spin-labeling) decreased during the early breath-hold phase whereas CBF remained almost stable during this phase and increased in the late phase. Cerebrovascular reactivity differed between the anterior and the posterior circulation during all phases. The cerebral energy metabolism of trained freedivers withstands severe hypoxic hypercarbia in prolonged breath-hold due to a complex cerebrovascular hemodynamic response.

A group of 59 patients with untreated histologically proved T2–T4 oropharyngeal squamous cell carcinoma were retrospectively analyzed. Human papillomavirus status was determined by viral DNA detection on tissue samples. MR imaging protocol included T2-weighted, contrast-enhanced T1-weighted, and DWI sequences. Parametric maps of ADC were obtained from DWI sequences. Texture analysis was performed on T2 and volumetric-interpolated brain examination sequences and on ADC maps. ADC was significantly lower in oropharyngeal squamous cell carcinoma positive for human papillomavirus compared with oropharyngeal squamous cell carcinoma negative for it. ADC and smoking status allowed noninvasive prediction of human papillomavirus status with a good accuracy.