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Research ArticlePediatrics

Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion

M.T. Whitehead, A. Smitthimedhin, J. Webb, E.S. Mahdi, Z.P. Khademian, J.L. Carpenter and A. Abraham
American Journal of Neuroradiology November 2018, 39 (11) 2132-2139; DOI: https://doi.org/10.3174/ajnr.A5830
M.T. Whitehead
aFrom the Departments of Radiology (M.T.W., A.S., E.S.M., Z.P.K.)
dGeorge Washington University Hospital (M.T.W., J.W., Z.P.K., J.L.C., A.A.), Washington, DC.
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A. Smitthimedhin
aFrom the Departments of Radiology (M.T.W., A.S., E.S.M., Z.P.K.)
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J. Webb
bHematology (J.W., A.A.)
dGeorge Washington University Hospital (M.T.W., J.W., Z.P.K., J.L.C., A.A.), Washington, DC.
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E.S. Mahdi
aFrom the Departments of Radiology (M.T.W., A.S., E.S.M., Z.P.K.)
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Z.P. Khademian
aFrom the Departments of Radiology (M.T.W., A.S., E.S.M., Z.P.K.)
dGeorge Washington University Hospital (M.T.W., J.W., Z.P.K., J.L.C., A.A.), Washington, DC.
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J.L. Carpenter
cNeurology (J.L.C.), Children's National Medical Center, Washington, DC
dGeorge Washington University Hospital (M.T.W., J.W., Z.P.K., J.L.C., A.A.), Washington, DC.
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A. Abraham
bHematology (J.W., A.A.)
dGeorge Washington University Hospital (M.T.W., J.W., Z.P.K., J.L.C., A.A.), Washington, DC.
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References

  1. 1.↵
    Sickle Cell Disease (SCD). Centers for Disease Control and Prevention. Updated August 31, 2016. https://www.cdc.gov/ncbddd/sicklecell/data.html. Accessed September 14, 2018..
  2. 2.↵
    1. Elias EJ,
    2. Liao JH,
    3. Jara H, et al
    . Quantitative MRI analysis of craniofacial bone marrow in patients with sickle cell disease. AJNR Am J Neuroradiol 2013;34:622–27 doi:10.3174/ajnr.A3240 pmid:22878006
    Abstract/FREE Full Text
  3. 3.↵
    1. Saito N,
    2. Nadgir RN,
    3. Flower EN, et al
    . Clinical and radiologic manifestations of sickle cell disease in the head and neck. Radiographics 2010;30:1021–34 doi:10.1148/rg.304095171 pmid:20631366
    CrossRefPubMed
  4. 4.↵
    1. Park S,
    2. Kwack KS,
    3. Chung NS, et al
    . Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging of focal vertebral bone marrow lesions: initial experience of the differentiation of nodular hyperplastic hematopoietic bone marrow from malignant lesions. Skeletal Radiol 2017;46:675–83 doi:10.1007/s00256-017-2603-z pmid:28265697
    CrossRefPubMed
  5. 5.↵
    1. Kosinski PD,
    2. Croal PL,
    3. Leung J, et al
    . The severity of anaemia depletes cerebrovascular dilatory reserve in children with sickle cell disease: a quantitative magnetic resonance imaging study. Br J Haematol 2017;176:280–87 doi:10.1111/bjh.14424 pmid:27905100
    CrossRefPubMed
  6. 6.↵
    1. Arkuszewski M,
    2. Krejza J,
    3. Chen R, et al
    . Sickle cell anemia: reference values of cerebral blood flow determined by continuous arterial spin labeling MRI. Neuroradiol J 2013;26:191–200 doi:10.1177/197140091302600209 pmid:23859242
    CrossRefPubMed
  7. 7.↵
    1. Alsop DC,
    2. Detre JA,
    3. Golay X, et al
    . Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 2015;73:102–16 doi:10.1002/mrm.25197 pmid:24715426
    CrossRefPubMed
  8. 8.↵
    1. Grade M,
    2. Hernandez Tamames JA,
    3. Pizzini FB, et al
    . A neuroradiologist's guide to arterial spin labeling MRI in clinical practice. Neuroradiology 2015;57:1181–202 doi:10.1007/s00234-015-1571-z pmid:26351201
    CrossRefPubMed
  9. 9.↵
    1. Deibler AR,
    2. Pollock JM,
    3. Kraft RA, et al
    . Arterial spin-labeling in routine clinical practice, Part 1: techniques and artifacts. AJNR Am J Neuroradiol 2008;29:1228–34 doi:10.3174/ajnr.A1030 pmid:18372417
    Abstract/FREE Full Text
  10. 10.↵
    1. Deibler AR,
    2. Pollock JM,
    3. Kraft RA, et al
    . Arterial spin-labeling in routine clinical practice, Part 2: hypoperfusion patterns. AJNR Am J Neuroradiol 2008;29:1235–41 doi:10.3174/ajnr.A1033 pmid:18356467
    Abstract/FREE Full Text
  11. 11.↵
    1. Deibler AR,
    2. Pollock JM,
    3. Kraft RA, et al
    . Arterial spin-labeling in routine clinical practice, Part 3: hyperperfusion patterns. AJNR Am J Neuroradiol 2008;29:1428–35 doi:10.3174/ajnr.A1034 pmid:18356466
    Abstract/FREE Full Text
  12. 12.↵
    1. Hales PW,
    2. Kirkham FJ,
    3. Clark CA
    . A general model to calculate the spin-lattice (T1) relaxation time of blood, accounting for haematocrit, oxygen saturation and magnetic field strength. J Cereb Blood Flow Metab 2016;36:370–74 doi:10.1177/0271678X15605856 pmid:26661147
    CrossRefPubMed
  13. 13.↵
    1. Gluckman E,
    2. Cappelli B,
    3. Bernaudin F, et al
    ; Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research. Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation. Blood 2017;129:1548–56 doi:10.1182/blood-2016-10-745711 pmid:27965196
    Abstract/FREE Full Text
  14. 14.↵
    1. Shenoy S,
    2. Eapen M,
    3. Panepinto JA, et al
    . A trial of unrelated donor marrow transplantation for children with severe sickle cell disease. Blood 2016;128:2561–67 doi:10.1182/blood-2016-05-715870 pmid:27625358
    Abstract/FREE Full Text
  15. 15.↵
    1. Dalle JH
    . Hematopoietic stem cell transplantation in SCD. C R Biol 2013;336:148–51 doi:10.1016/j.crvi.2012.09.004 pmid:23643397
    CrossRefPubMed
  16. 16.↵
    1. Walters MC
    . Update of hematopoietic cell transplantation for sickle cell disease. Curr Opin Hematol 2015;22:227–33 doi:10.1097/MOH.0000000000000136 pmid:25767957
    CrossRefPubMed
  17. 17.↵
    1. Fitzhugh CD,
    2. Abraham AA,
    3. Tisdale JF, et al
    . Hematopoietic stem cell transplantation for patients with sickle cell disease: progress and future directions. Hematol Oncol Clin North Am 2014;28:1171–85 doi:10.1016/j.hoc.2014.08.014 pmid:25459186
    CrossRefPubMed
  18. 18.↵
    1. Angelucci E,
    2. Matthes-Martin S,
    3. Baronciani D, et al
    ; EBMT Inborn Error and EBMT Paediatric Working Parties. Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel. Haematologica 2014;99:811–20 doi:10.3324/haematol.2013.099747 pmid:24790059
    Abstract/FREE Full Text
  19. 19.↵
    1. Dedeken L,
    2. Lê PQ,
    3. Azzi N, et al
    . Haematopoietic stem cell transplantation for severe sickle cell disease in childhood: a single centre experience of 50 patients. Br J Haematol 2014;165:402–08 doi:10.1111/bjh.12737 pmid:24433465
    CrossRefPubMed
  20. 20.↵
    1. Gluckman E
    . Allogenic transplantation strategies including haploidentical transplantation in sickle cell disease. Hematol Am Soc Hematol Educ Program 2013;2013:370–76 doi:10.1182/asheducation-2013.1.370 pmid:24319206
    Abstract/FREE Full Text
  21. 21.↵
    1. Wintermark M,
    2. Lepori D,
    3. Cotting J, et al
    . Brain perfusion in children: evolution with age assessed by quantitative perfusion computed tomography. Pediatrics 2004;113:1642–52 doi:10.1542/peds.113.6.1642 pmid:15173485
    Abstract/FREE Full Text
  22. 22.↵
    1. Goetti R,
    2. O'Gorman R,
    3. Khan N, et al
    . Arterial spin labeling MRI for assessment of cerebral perfusion in children with moyamoya disease: comparison with dynamic susceptibility contrast MRI. Neuroradiology 2013;55:639–47 doi:10.1007/s00234-013-1155-8 pmid:23404242
    CrossRefPubMed
  23. 23.↵
    1. Guilliams KP,
    2. Fields ME,
    3. Ragan DK, et al
    . Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia. Blood 2018;131:1012–21 doi:10.1182/blood-2017-06-789842 pmid:29255068
    Abstract/FREE Full Text
  24. 24.↵
    1. Wu WC,
    2. St Lawrence KS,
    3. Licht DJ, et al
    . Quantification issues in arterial spin labeling perfusion magnetic resonance imaging. Top Magn Reson Imaging 2010;21:65–73. doi:10.1097/RMR.0b013e31821e570a pmid:21613872
    CrossRefPubMed
  25. 25.↵
    1. Václavů L,
    2. van der Land V,
    3. Heijtel DF, et al
    . In vivo T1 of blood measurements in children with sickle cell disease improve cerebral blood flow quantification from arterial spin-labeling MRI. AJNR Am J Neuroradiol 2016;37:1727–32 doi:10.3174/ajnr.A4793 pmid:27231223
    Abstract/FREE Full Text
  26. 26.↵
    1. Hales PW,
    2. Kawadler JM,
    3. Aylett SE, et al
    . Arterial spin labeling characterization of cerebral perfusion during normal maturation from late childhood into adulthood: normal ‘reference range’ values and their use in clinical studies. J Cereb Blood Flow Metab 2014;34:776–84 doi:10.1038/jcbfm.2014.17 pmid:24496173
    CrossRefPubMed
  27. 27.↵
    1. Wang J,
    2. Licht DJ
    . Pediatric perfusion MR imaging using arterial spin labeling. Neuroimaging Clin N Am 2006;16:149–67, ix pmid:16543090
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Helton KJ,
    2. Paydar A,
    3. Glass J, et al
    . Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia. Pediatr Blood Cancer 2009;52:85–91 doi:10.1002/pbc.21745 pmid:18937311
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Dallas MH,
    2. Triplett B,
    3. Shook DR, et al
    . Long-term outcome and evaluation of organ function in pediatric patients undergoing haploidentical and matched related hematopoietic cell transplantation for sickle cell disease. Biol Blood Marrow Transplant 2013;19:820–30 doi:10.1016/j.bbmt.2013.02.010 pmid:23416852
    CrossRefPubMed
  30. 30.↵
    1. Bush A,
    2. Chai Y,
    3. Choi SY, et al
    . Pseudo continuous arterial spin labeling quantification in anemic subjects with hyperemic cerebral blood flow. Magn Reson Imaging 2018;47:137–46 doi:10.1016/j.mri.2017.12.011 pmid:29229306
    CrossRefPubMed
  31. 31.↵
    1. Gevers S,
    2. Nederveen AJ,
    3. Fijnvandraat K, et al
    . Arterial spin labeling measurement of cerebral perfusion in children with sickle cell disease. J Magn Reson Imaging 2012;35:779–87 doi:10.1002/jmri.23505 pmid:22095695
    CrossRefPubMed
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Cite this article
M.T. Whitehead, A. Smitthimedhin, J. Webb, E.S. Mahdi, Z.P. Khademian, J.L. Carpenter, A. Abraham
Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion
American Journal of Neuroradiology Nov 2018, 39 (11) 2132-2139; DOI: 10.3174/ajnr.A5830

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Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion
M.T. Whitehead, A. Smitthimedhin, J. Webb, E.S. Mahdi, Z.P. Khademian, J.L. Carpenter, A. Abraham
American Journal of Neuroradiology Nov 2018, 39 (11) 2132-2139; DOI: 10.3174/ajnr.A5830
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