Article Figures & Data
Figures
- Fig 1.
Flow chart showing the patient selection process. LGG indicates low-grade glioma; BCNU, biodegradable carmustine.
- Fig 2.
A representative case in the PDT group. Preoperative DWI (A), ADC map (G), CE-T1WI (M), and FLAIR (S) demonstrate the lesion with a cyst in the right frontal lobe. Postoperative DWI (B–F), ADC map (H–L), CE-T1WI (N–R), and FLAIR (T–X) show time-dependent changes after PDT.
- Fig 3.
A representative case in the non-PDT group. Preoperative DWI (A), ADC map (E), CE-T1WI (I), and FLAIR (M) demonstrate the lesion in the right temporal lobe. Postoperative DWI (B–D), ADC map (F–H), CE-T1WI (J–L), and FLAIR (N–P) show time-dependent changes after the operation.
- Fig 4.
Postoperative DWI (left) and ADC map (right) demonstrate representative settings for the ROIs in the PDT group (A) and non-PDT group (B). The small circles labeled 1–5 indicate the ROIs used for analysis of the ADC values. A line graph demonstrates the postoperative time-dependent change in ADC values in the PDT group (thick line) and non-PDT group (thin line) (C). Double asterisks indicate P < .01; triple asterisks, P < .001, Mann-Whitney U test.
- Fig 5.
DWI (A) and a schematic illustration of A (B) show the post-PDT changes in irradiated and nonirradiated areas on day 1 for 1 patient in the PDT group. The circle with the solid line indicates the area with PDT irradiation (w/PDT). The circle with the dotted line indicates the area without PDT irradiation (w/o PDT). The white arrow indicates the middle cerebral artery. The line graph shows the postoperative time-dependent changes in ADC values in areas with PDT (thick line) and without PDT (thin line) (C).
Tables
Patient characteristics
Characteristic PDT (n = 14) Non-PDT (n = 10) P Value Age (yr) .98 Median (range) 61.5 (35–70) 61.0 (36–72) Sex (No.) (%) .92 Male 8 (57) 6 (60) Female 6 (43) 4 (40) Preoperative Karnofsky Performance Status Scale score .17 Median (range) 80 (30–100) 70 (30–100) Tumor locations (No.) (%) .67 Frontal 9 (64) 5 (50) Temporal 3 (21) 4 (40) Parietal 1 (7) 1 (10) Basal ganglia 1 (7) 0 (0) Preoperative tumor volume (cm3) .07 Median (range) 31.7 (2.2–140.0) 70.3 (16.4–153.5) Extent of resection (No.) (%) .91 Gross-total 10 (71) 7 (70) Subtotal 2 (14) 1 (10) Partial 2 (14) 2 (20) Histopathology (No.) (%) .14 Glioblastoma 11 (79) 10 (10) Anaplastic astrocytoma 1 (7) 0 (0) Anaplastic oligodendroglioma 2 (14) 0 (0) Isocitrate dehydrogenase mutation status (No.) (%) .50 Wild-type 11 (79) 9 (90) Mutant 3 (21) 1 (10) MIB-1 index .65 Median (range) 20 (10–80) 20 (8–40)
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