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Research ArticleAdult Brain

Quantification of Iodine Leakage on Dual-Energy CT as a Marker of Blood-Brain Barrier Permeability in Traumatic Hemorrhagic Contusions: Prediction of Surgical Intervention for Intracranial Pressure Management

U.K. Bodanapally, K. Shanmuganathan, Y.P. Gunjan, G. Schwartzbauer, R. Kondaveti and T.R. Feiter
American Journal of Neuroradiology December 2019, 40 (12) 2059-2065; DOI: https://doi.org/10.3174/ajnr.A6316
U.K. Bodanapally
aFrom the Departments of Diagnostic Radiology and Nuclear Medicine (U.K.B., K.S., T.R.F.)
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K. Shanmuganathan
aFrom the Departments of Diagnostic Radiology and Nuclear Medicine (U.K.B., K.S., T.R.F.)
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Y.P. Gunjan
bNeurology (Y.P.G.)
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G. Schwartzbauer
cNeurosurgery (G.S.), R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, Maryland
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R. Kondaveti
dKasturba Medical College (R.K.), Mangaluru, India.
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T.R. Feiter
aFrom the Departments of Diagnostic Radiology and Nuclear Medicine (U.K.B., K.S., T.R.F.)
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    FIG.

    A 65-year-old man with traumatic brain injury sustained after a motor vehicle collision. A, Admission 120-kV image shows a hemorrhagic contusion in the left frontoparietal lobe and measured volume (A = 11.4 cm3). B, Follow-up axial 120-kV image shows hemorrhagic progression of contusions with increased volume of the existing hematoma (B = 38.3 cm3) with multiple new hemorrhagic contusions. The image also shows areas of contrast leakage (arrowheads). C, Virtual high-monochromatic image (190 kV) shows smaller hemorrhagic contusion volume (C = 27.9 cm3), compared with 120 -kV images due to a negligible attenuation contribution from leaked iodinated contrast. D, Iodine overlay image shows contrast staining of the penumbra and parapenumbra of hemorrhagic contusions (arrowheads). An ROI is drawn around the largest hematoma to measure the iodine concentration (0.8 mg/mL).

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    Table 1:

    Unadjusted associations among predictor variables, surgical management of intracranial pressure, and decompressive craniectomy

    VariablesUnadjusted Odds Ratios (95% CI) (Surgical Management)P ValueUnadjusted Odds Ratios (95% CI) (Craniectomy)P Value
    Age (yr)0.96 (0.93–0.98).004a0.94 (0.88–0.99).04a
    Sex, men vs women0.94 (0.27–3.2).92b0.35 (0.07–1.77).34c
    P-GCS0.63 (0.5, 0.8)<.001a0.78 (0.6–1).05
    Motor score0.43 (0.25–0.76).003a0.7 (0.44–1.14).15
    Systolic BP (mm Hg)0.99 (0.97–1).151.01 (0.98,1.04).46
    Diastolic BP (mm Hg)0.99 (0.97–1.03).841 (0.96–1.05).72
    PT (seconds)0.98 (0.84–1.14).780.93 (0.67–1.3).64
    aPTT (seconds)1.03 (0.92–1.15).571 (0.85–1.18).93
    Fibrinogen (mg/dL)0.98 (0.97–0.99).002a0.99 (0.98–1).06
    Platelets (103/μL)1 (0.99–1.01).811 (0.99–1.01).4
    Marshall CT score
     DI II13.46 (0.55–21.9).2c
     DI III and 1V4.27 (0.9–20).06c
    Hemorrhagic progression1.12 (0.35–3.54).85b2.84 (0.32–25.4).31c
    Fraction of hemorrhagic progression1.02 (0.96–1.11).491 (0.91–1.1).88
    Iodine concentration (mg/mL)44 (3.03–641).005a16 (0.58–442).1
    Hematoma volume on admission CT (cm3)1.05 (0.97–1.13).211.04 (0.95–1.14).4
    Hematoma volume on follow-up CT (cm3)1.06 (1–1.12).04a1.04 (0.99–1.1).1
    Total pseudohematoma from all contusions (cm3)1.32 (1.06–1.64).01a1.1 (0.99–1.23).06
    Fractional pseudohematoma to true hematoma2.66 (0.6–11.8).192.43 (0.3–18.9).39
    Iodine quantity in all pseudohematomas (mg)1.48 (1.04–2.11).03a1.04 (0.96–1.13).3
    Iodine quantity in all contusions (mg)1.1 (1.01–1.21).02a1.03 (0.98–1.08).15
    • Note—BP indicates blood pressure; DI, diffuse injury; PT, prothrombin time; aPTT, activated partial thromboplastin time.

    • ↵a Significant.

    • ↵b Pearson.

    • ↵c Fisher exact test.

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    Table 2:

    Adjusted associations among predictor variables, surgical management of intracranial pressure, and decompressive craniectomy

    VariablesAdjusted Odds Ratios (95% CI) (Surgical Management)P ValueAdjusted Odds Ratios (95% CI) (Craniectomy)P Value
    Age (yr)0.9 (0.85–0.97).003a0.89 (0.81–0.99).03a
    Total pseudohematoma from all contusions (cm3)2.05 (1.11–3.77).02a1.23 (1.03–1.45).02a
    P-GCS0.55 (0.38–0.79).001a
    • ↵a Significant.

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American Journal of Neuroradiology: 40 (12)
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U.K. Bodanapally, K. Shanmuganathan, Y.P. Gunjan, G. Schwartzbauer, R. Kondaveti, T.R. Feiter
Quantification of Iodine Leakage on Dual-Energy CT as a Marker of Blood-Brain Barrier Permeability in Traumatic Hemorrhagic Contusions: Prediction of Surgical Intervention for Intracranial Pressure Management
American Journal of Neuroradiology Dec 2019, 40 (12) 2059-2065; DOI: 10.3174/ajnr.A6316

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Quantification of Iodine Leakage on Dual-Energy CT as a Marker of Blood-Brain Barrier Permeability in Traumatic Hemorrhagic Contusions: Prediction of Surgical Intervention for Intracranial Pressure Management
U.K. Bodanapally, K. Shanmuganathan, Y.P. Gunjan, G. Schwartzbauer, R. Kondaveti, T.R. Feiter
American Journal of Neuroradiology Dec 2019, 40 (12) 2059-2065; DOI: 10.3174/ajnr.A6316
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