Predicting Motor Outcome in Acute Intracerebral Hemorrhage

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Fig 1.
Assessing corticospinal tract involvement with diffusion tensor tractography superimposed on gradient recalled echo and FLAIR images. In the upper row, the corticospinal tract was affected by ICH (passes through it) at the level of the corona radiata and posterior limb of the internal capsule. Note that in lower row, the corticospinal tract was displaced slightly forward but preserved around the intracerebral hematoma. Vol indicates volume.
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Fig 2.
Example of ROI object maps used to measure intracerebral hematoma (blue) and perihematomal edema (yellow) volumes.

Functional motor outcome prediction: summary of class performance and odds ratios for univariate and multivariate analyses at admission and at 72 hr

Variables	Cutoff	AUC (95% CI)	Sensitivity	Specificity	Positive Predictive Value	Negative Predictive Value	P Value	Odds Ratio (95% CI)
NIHSS score at admission	15	0.77 (0.62–0.93)	0.69	0.77	0.56	0.85	.011	1.23 (1.05–1.43)
mNIHSS score at admission	6	0.79 (0.64–0.94)	0.77	0.77	0.59	0.88	.007	1.65 (1.15–2.36)
ICH volume at admission	17.08	0.71 (0.54–0.90)	0.38	0.86	0.50	0.80	.047	1.05 (1.00–1.10)
CST involvement by ICH at admission	Present	0.70 (0.56–0.84)	0.84	0.55	0.46	0.89	.025	6.77 (1.27–36.14)
PLIC involvement by ICH at admission	Present	0.76 (0.61–0.91)	0.69	0.83	0.64	0.86	.002	10.80 (2.36–49.46)
NIHSS score at 72 hr	8	0.88 (0.77–0.99)	0.92	0.67	0.54	0.95	<.001	1.31 (1.12–1.52)
mNIHSS score at 72 hr	5	0.91 (0.82–1.00)	0.92	0.83	0.71	0.96	<.001	2.10 (1.36–3.26)
NIHSS score at admission, PLIC involvement by ICH at admission	16 Present	0.87 (0.75–0.98)	0.85	0.86	0.73	0.93	.014 .005	1.25 (1.05–1.49), 14.21 (2.23–90.60)
mNIHSS score at admission, PLIC involvement by ICH at admission	6 Present	0.89 (0.78–1.00)	0.84	0.79	0.65	0.92	.009 .005	1.86 (1.17–2.94), 20.99 (2.52–174.80)
NIHSS score at 72 hr, PLIC involvement by ICH at admission	14 Present	0.93 (0.84–1.00)	0.85	0.93	0.85	0.93	.003 .017	1.32 (1.10- 1.58), 13.73 (1.60–117.65)
mNIHSS score at 72 hr, PLIC involvement by ICH at admission	3 Absent	0.94 (0.86–1.00)	0.92	0.86	0.75	0.96	.005 .020	2.08 (1.25–3.50), 17.04 (1.56–186.18)